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    Dnajb5 DnaJ heat shock protein family (Hsp40) member B5 [ Mus musculus (house mouse) ]

    Gene ID: 56323, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dnajb5provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B5provided by MGI
    Primary source
    MGI:MGI:1930018
    See related
    Ensembl:ENSMUSG00000036052 AllianceGenome:MGI:1930018
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hsc40; Hsp40-3; 1110058L06Rik
    Summary
    Predicted to enable protein-folding chaperone binding activity and unfolded protein binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Is expressed in several structures, including nervous system; olfactory epithelium; retina; skeletal musculature; and tongue. Orthologous to human DNAJB5 (DnaJ heat shock protein family (Hsp40) member B5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 18.7), cortex adult (RPKM 13.6) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnajb5 in Genome Data Viewer
    Location:
    4 A5; 4 22.93 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (42949866..42959425)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (42949867..42959425)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930578G10 gene Neighboring gene spermatogenesis associated 31 subfamily F member 3 Neighboring gene PHD finger protein 24 Neighboring gene predicted gene, 52697 Neighboring gene STARR-positive B cell enhancer ABC_E660 Neighboring gene SPATA31 subfamily G member 1 Neighboring gene STARR-seq mESC enhancer starr_10043 Neighboring gene STARR-positive B cell enhancer ABC_E46 Neighboring gene valosin containing protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration. San Gil R, et al. Nat Commun, 2024 Feb 19. PMID 38374041, Free PMC Article
    2. Hsc40, a new member of the hsp40 family, exhibits similar expression profile to that of hsc70 in mammalian cells. Chen MS, et al. Gene, 1999 Oct 1. PMID 10570961
    3. A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Ago T, et al. Cell, 2008 Jun 13. PMID 18555775
    4. Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature. Ohtsuka K, et al. Cell Stress Chaperones, 2000 Apr. PMID 11147971, Free PMC Article
    5. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dnaJ homolog subfamily B member 5
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 5
    heat shock protein cognate 40
    heat shock protein hsp40-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355438.2 → NP_001342367.1  dnaJ homolog subfamily B member 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL672276
      UniProtKB/TrEMBL
      Q3TYL4
      Conserved Domains (1) summary
      COG0484
      Location:72 → 415
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    2. NM_001355439.2 → NP_001342368.1  dnaJ homolog subfamily B member 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672276
      Consensus CDS
      CCDS89731.1
      UniProtKB/TrEMBL
      A2AG30, Q3TYL4
      Conserved Domains (1) summary
      COG0484
      Location:34 → 377
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    3. NM_001355440.1 → NP_001342369.1  dnaJ homolog subfamily B member 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK158972, BQ177080
      Consensus CDS
      CCDS18084.1
      UniProtKB/Swiss-Prot
      O89114
      UniProtKB/TrEMBL
      Q3TY13, Q3TYL4
      Related
      ENSMUSP00000081712.6, ENSMUST00000084662.12
      Conserved Domains (1) summary
      COG0484
      Location:1 → 343
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    4. NM_001374167.1 → NP_001361096.1  dnaJ homolog subfamily B member 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK158535, AK158972, BQ177080, BY233748
      Consensus CDS
      CCDS18084.1
      UniProtKB/Swiss-Prot
      O89114
      UniProtKB/TrEMBL
      Q3TY13, Q3TYL4
      Conserved Domains (1) summary
      COG0484
      Location:1 → 343
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    5. NM_001374168.1 → NP_001361097.1  dnaJ homolog subfamily B member 5 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK158535, AK158972, BQ177080
      Consensus CDS
      CCDS18084.1
      UniProtKB/Swiss-Prot
      O89114
      UniProtKB/TrEMBL
      Q3TY13, Q3TYL4
      Related
      ENSMUSP00000095716.3, ENSMUST00000098112.9
      Conserved Domains (1) summary
      COG0484
      Location:1 → 343
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    6. NM_001374169.1 → NP_001361098.1  dnaJ homolog subfamily B member 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK158535, AK158972, BQ177080, CX235957
      UniProtKB/TrEMBL
      A2AG30, Q3TYL4
      Related
      ENSMUSP00000040451.4, ENSMUST00000037872.10
      Conserved Domains (1) summary
      COG0484
      Location:34 → 377
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      42949866..42959425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164265.1 → XP_036020158.1  dnaJ homolog subfamily B member 5 isoform X1

      Conserved Domains (1) summary
      cd10747
      Location:41 → 205
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

    2. XM_036164264.1 → XP_036020157.1  dnaJ homolog subfamily B member 5 isoform X1

      Conserved Domains (1) summary
      cd10747
      Location:41 → 205
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

    3. XM_036164259.1 → XP_036020152.1  dnaJ homolog subfamily B member 5 isoform X1

      Conserved Domains (1) summary
      cd10747
      Location:41 → 205
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

    4. XM_036164260.1 → XP_036020153.1  dnaJ homolog subfamily B member 5 isoform X1

      Conserved Domains (1) summary
      cd10747
      Location:41 → 205
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

    5. XM_036164263.1 → XP_036020156.1  dnaJ homolog subfamily B member 5 isoform X1

      Conserved Domains (1) summary
      cd10747
      Location:41 → 205
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

    6. XM_036164261.1 → XP_036020154.1  dnaJ homolog subfamily B member 5 isoform X1

      Conserved Domains (1) summary
      cd10747
      Location:41 → 205
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

    7. XM_036164262.1 → XP_036020155.1  dnaJ homolog subfamily B member 5 isoform X1

      Conserved Domains (1) summary
      cd10747
      Location:41 → 205
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_019874.3: Suppressed sequence

      Description
      NM_019874.3: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O89114.1 GenPept UniProtKB/Swiss-Prot:O89114

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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