Oga O-GlcNAcase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ogaprovided by MGI
Official Full Name: O-GlcNAcaseprovided by MGI
Primary source: MGI:MGI:1932139
See related: Ensembl:ENSMUSG00000025220 AllianceGenome:MGI:1932139
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hy5; Mgea5; Ncoat
Summary: Predicted to enable histone acetyltransferase activity; hydrolase activity, hydrolyzing O-glycosyl compounds; and identical protein binding activity. Predicted to be involved in several processes, including positive regulation of mitochondrial depolarization; positive regulation of transport; and regulation of protein metabolic process. Predicted to be located in cytosol. Is expressed in brain; liver; and retina nuclear layer. Orthologous to human OGA (O-GlcNAcase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 28.1), CNS E11.5 (RPKM 27.8) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 38.75 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (45738698..45772274, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (45750255..45783644, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Restoration of coronary microvascular function by OGA overexpression in a high-fat diet with low-dose streptozotocin-induced type 2 diabetic mice.
Title: Restoration of coronary microvascular function by OGA overexpression in a high-fat diet with low-dose streptozotocin-induced type 2 diabetic mice.
Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice.
Title: Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice.
Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis.
Title: Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis.
Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.
Title: Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity.
Furthermore, both Ogt and Oga were required for the reversion from primed ESD-EpiSCs to naive rESCs. These findings indicate that O-GlcNAcylation plays an important role in the survival of primed ESD-EpiSCs and in their reversion to naive rESCs.
Title: O-GlcNAc is required for the survival of primed pluripotent stem cells and their reversion to the naïve state.
the O-linked N-acetylglucosamine (O-GlcNAc) processing enzymes, O-GlcNAc-transferase (OGT) and O-GlcNAcase (OGA), interact with the (A)gamma-globin promoter at the -566 GATA repressor site
Title: O-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2β Protein at the Aγ-Globin Promoter.
Oga(+/-) mice resist high-fat diet-induced obesity with ameliorated hepatic steatosis and improved glucose metabolism
Title: Obesity resistance and increased energy expenditure by white adipose tissue browning in Oga(+/-) mice.
plays a critical role in placental vasculogenesis by modulating HIF-1alpha stabilization
Title: O-GlcNAc cycling enzymes control vascular development of the placenta by modulating the levels of HIF-1α.
E2F1 negatively regulates both Ogt and Mgea5 expression in an Rb1 protein-dependent manner.
Title: E2F1 Transcription Factor Regulates O-linked N-acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Expression.
Conditional disruption of the O-GlcNAcase in mice leads to metabolic deregulation and semi-penetrant perinatal lethality.
Title: Conditional knock-out reveals a requirement for O-linked N-Acetylglucosaminase (O-GlcNAcase) in metabolic homeostasis.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132562 (e-PCR)
- UniSTS:215845

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

BB241644 (e-PCR)
- UniSTS:209474

D19Ertd409e (e-PCR), detects polymorphism
- UniSTS:167246

RH125779 (e-PCR)
- UniSTS:162526

Clone Names

mKIAA0679, 2810009A20Rik, 4833427O07Rik, 5830447M11Rik

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity	IEA Inferred from Electronic Annotation more info
enables [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity	ISO Inferred from Sequence Orthology more info
enables beta-N-acetylglucosaminidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-N-acetylglucosaminidase activity	ISO Inferred from Sequence Orthology more info
enables hexosaminidase activity	IEA Inferred from Electronic Annotation more info
enables histone acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in N-acetylglucosamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in N-acetylglucosamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in dATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycoprotein metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cardiac muscle adaptation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell killing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of growth hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial depolarization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein-containing complex disassembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in protein deglycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein O-GlcNAcase

Names: N-acetyl-beta-D-glucosaminidase; N-acetyl-beta-glucosaminidase; beta-N-acetylhexosaminidase; beta-hexosaminidase; bifunctional protein NCOAT; meningioma expressed antigen 5 (hyaluronidase); meningioma-expressed antigen 5; nuclear cytoplasmic O-GlcNAcase and acetyltransferase

NP_001390278.1

EC 3.2.1.169

NP_001390280.1

EC 3.2.1.169

NP_001390281.1

EC 3.2.1.169

NP_001390282.1

EC 3.2.1.169

NP_076288.1

EC 3.2.1.169

XP_017173794.2

EC 3.2.1.169

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403349.1 → NP_001390278.1 protein O-GlcNAcase isoform 2

Status: VALIDATED

Source sequence(s)

AC149086
NM_001403351.1 → NP_001390280.1 protein O-GlcNAcase isoform 3

Status: VALIDATED

Source sequence(s)

AC149086
NM_001403352.1 → NP_001390281.1 protein O-GlcNAcase isoform 4

Status: VALIDATED

Source sequence(s)

AC149086
NM_001403353.1 → NP_001390282.1 protein O-GlcNAcase isoform 5

Status: VALIDATED

Source sequence(s)

AC149086
NM_023799.5 → NP_076288.1 protein O-GlcNAcase isoform 1

See identical proteins and their annotated locations for NP_076288.1

Status: VALIDATED

Source sequence(s)

AC149086

Consensus CDS

CCDS29866.1

UniProtKB/Swiss-Prot

Q3ULY7, Q6ZQ71, Q8BK05, Q8BTT2, Q8CFX2, Q9CSJ4, Q9CUR7, Q9EQQ9

Related

ENSMUSP00000026243.4, ENSMUST00000026243.5

Conserved Domains (1) summary

pfam07555
Location:62 → 338

NAGidase; beta-N-acetylglucosaminidase

RNA

NR_151594.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC149086

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

45738698..45772274 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318305.3 → XP_017173794.2 protein O-GlcNAcase isoform X2

UniProtKB/TrEMBL

Q05CX1

Conserved Domains (1) summary

pfam07555
Location:100 → 376

NAGidase; beta-N-acetylglucosaminidase