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    Rnf144b ring finger protein 144B [ Mus musculus (house mouse) ]

    Gene ID: 218215, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf144bprovided by MGI
    Official Full Name
    ring finger protein 144Bprovided by MGI
    Primary source
    MGI:MGI:2384986
    See related
    Ensembl:ENSMUSG00000038068 AllianceGenome:MGI:2384986
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pir2; Ibrdc2; E130105P19Rik
    Summary
    Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of apoptotic process and ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in mitochondrial membrane. Is expressed in several structures, including bladder; cranium; hindbrain ventricular layer; jaw; and thoracic segment skeleton. Orthologous to human RNF144B (ring finger protein 144B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 19.3), testis adult (RPKM 8.0) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf144b in Genome Data Viewer
    Location:
    13 A5; 13 24.5 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (47276196..47401470)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (47122720..47247991)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1875 Neighboring gene lysine (K)-specific demethylase 1B Neighboring gene STARR-seq mESC enhancer starr_34433 Neighboring gene STARR-seq mESC enhancer starr_34434 Neighboring gene DEK proto-oncogene Neighboring gene RIKEN cDNA A930002C04 gene Neighboring gene predicted gene, 40935 Neighboring gene STARR-seq mESC enhancer starr_34435 Neighboring gene predicted gene, 40934 Neighboring gene predicted gene, 52039 Neighboring gene predicted gene, 53785 Neighboring gene STARR-seq mESC enhancer starr_34438 Neighboring gene STARR-seq mESC enhancer starr_34442 Neighboring gene predicted gene, 57608 Neighboring gene predicted gene, 35733

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. RNF144B negatively regulates antiviral immunity by targeting MDA5 for autophagic degradation. Li G, et al. EMBO Rep, 2024 Oct. PMID 39285245, Free PMC Article
    2. Rnf144b alleviates the inflammatory responses and cardiac dysfunction in sepsis. Guo R, et al. ESC Heart Fail, 2023 Aug. PMID 37088470, Free PMC Article
    3. The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability. Abad E, et al. J Exp Clin Cancer Res, 2024 Apr 29. PMID 38685100, Free PMC Article
    4. Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2. Sayan BS, et al. Proc Natl Acad Sci U S A, 2010 Jul 20. PMID 20615966, Free PMC Article
    5. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNF144B negatively regulates antiviral immunity by targeting MDA5 for autophagic degradation.
      Title: RNF144B negatively regulates antiviral immunity by targeting MDA5 for autophagic degradation.
    2. The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability.
      Title: The TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability.
    3. Rnf144b alleviates the inflammatory responses and cardiac dysfunction in sepsis.
      Title: Rnf144b alleviates the inflammatory responses and cardiac dysfunction in sepsis.
    4. PIR2, by being induced by TAp73 and degrading DeltaNp73, differentially regulates TAp73/DeltaNp73 stability.[PIR2]
      Title: Differential control of TAp73 and DeltaNp73 protein stability by the ring finger ubiquitin ligase PIR2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC32473

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrial membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF144B
    Names
    IBR domain containing 2
    IBR domain-containing protein 2
    NP_001164114.1
    NP_666154.3
    XP_036013887.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170643.1 → NP_001164114.1  E3 ubiquitin-protein ligase RNF144B

      See identical proteins and their annotated locations for NP_001164114.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC131085, AK040939, BB661852
      Consensus CDS
      CCDS26491.1
      UniProtKB/Swiss-Prot
      Q8BG97, Q8BKD6, Q8R195
      Related
      ENSMUSP00000105738.3, ENSMUST00000110111.4
      Conserved Domains (2) summary
      smart00647
      Location:101 → 166
      IBR; In Between Ring fingers
      pfam01485
      Location:183 → 223
      IBR; IBR domain, a half RING-finger domain

    2. NM_146042.4 → NP_666154.3  E3 ubiquitin-protein ligase RNF144B

      See identical proteins and their annotated locations for NP_666154.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC131085, AK040939, AK053529
      Consensus CDS
      CCDS26491.1
      UniProtKB/Swiss-Prot
      Q8BG97, Q8BKD6, Q8R195
      Related
      ENSMUSP00000071017.5, ENSMUST00000068891.12
      Conserved Domains (2) summary
      smart00647
      Location:101 → 166
      IBR; In Between Ring fingers
      pfam01485
      Location:183 → 223
      IBR; IBR domain, a half RING-finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      47276196..47401470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157994.1 → XP_036013887.1  E3 ubiquitin-protein ligase RNF144B isoform X1

      Conserved Domains (3) summary
      smart00647
      Location:66 → 131
      IBR; In Between Ring fingers
      pfam01485
      Location:148 → 188
      IBR; IBR domain, a half RING-finger domain
      cl17238
      Location:28 → 55
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BKD6.2 GenPept UniProtKB/Swiss-Prot:Q8BKD6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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