Cpq carboxypeptidase Q [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cpqprovided by MGI
Official Full Name: carboxypeptidase Qprovided by MGI
Primary source: MGI:MGI:1889205
See related: Ensembl:ENSMUSG00000039007 AllianceGenome:MGI:1889205
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hls2; Pgcp; Lal-1; 1190003P12Rik; 2610034C17Rik
Summary: Predicted to enable metallodipeptidase activity and protein homodimerization activity. Predicted to be involved in several processes, including peptide catabolic process; thyroid hormone generation; and tissue regeneration. Located in lysosome. Is expressed in genitourinary system. Orthologous to human CPQ (carboxypeptidase Q). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 26.1), subcutaneous fat pad adult (RPKM 15.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 13.74 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (33083275..33594698)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (33083129..33594552)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallodipeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallodipeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallodipeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in peptide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in peptide catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in thyroid hormone generation	IBA Inferred from Biological aspect of Ancestor more info
involved_in thyroid hormone generation	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone generation	ISS Inferred from Sequence or Structural Similarity more info
involved_in tissue regeneration	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: carboxypeptidase Q

Names: hematopoietic lineage switch 2; plasma glutamate carboxypeptidase

NP_061225.2

EC 3.4.17.-

NP_788262.1

EC 3.4.17.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018755.2 → NP_061225.2 carboxypeptidase Q precursor

See identical proteins and their annotated locations for NP_061225.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK152145, BB472698, CK624628

Consensus CDS

CCDS27414.1

UniProtKB/Swiss-Prot

O70216, Q3U8N9, Q9WVJ3

Related

ENSMUSP00000154400.2, ENSMUST00000228916.2

Conserved Domains (2) summary

cd03883
Location:45 → 447

M28_Pgcp_like; M28 Zn-Peptidase Plasma glutamate carboxypeptidase

cd04815
Location:128 → 254

PA_M28_2; PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions. ...
NM_176073.4 → NP_788262.1 carboxypeptidase Q precursor

See identical proteins and their annotated locations for NP_788262.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK135096, BB472698, CK624628

Consensus CDS

CCDS27414.1

UniProtKB/Swiss-Prot

O70216, Q3U8N9, Q9WVJ3

Related

ENSMUSP00000039046.10, ENSMUST00000042167.10

Conserved Domains (2) summary

cd03883
Location:45 → 447

M28_Pgcp_like; M28 Zn-Peptidase Plasma glutamate carboxypeptidase

cd04815
Location:128 → 254

PA_M28_2; PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions. ...