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    Slc10a3 solute carrier family 10 (sodium/bile acid cotransporter family), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 214601, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slc10a3provided by MGI
    Official Full Name
    solute carrier family 10 (sodium/bile acid cotransporter family), member 3provided by MGI
    Primary source
    MGI:MGI:95048
    See related
    Ensembl:ENSMUSG00000032806 AllianceGenome:MGI:95048
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P3; DXS253Eh; DXSmhG28; DXHXS253E
    Summary
    Predicted to enable bile acid:sodium symporter activity. Acts upstream of or within response to retinoic acid. Predicted to be located in membrane. Is expressed in several structures, including brain ventricle and choroid plexus; facial bone primordium; genitourinary system; integumental system; and lung. Orthologous to human SLC10A3 (solute carrier family 10 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 25.9), mammary gland adult (RPKM 21.6) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc10a3 in Genome Data Viewer
    Location:
    X A7.3; X 38.0 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73412823..73416955, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74369217..74373349, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene L antigen family, member 3 Neighboring gene predicted readthrough transcript (NMD candidate), 44504 Neighboring gene ubiquitin-like 4A Neighboring gene FAM3 metabolism regulating signaling molecule A Neighboring gene STARR-seq mESC enhancer starr_47367 Neighboring gene inhibitor of kappaB kinase gamma Neighboring gene glucose-6-phosphate dehydrogenase X-linked Neighboring gene STARR-positive B cell enhancer ABC_E11050

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sequence analysis of two exons from the murine dystrophin locus. Maconochie MK, et al. Mamm Genome, 1992. PMID 1543903
    2. Extension of the physical map in the region of the mouse X chromosome homologous to human Xq28 and identification of an exception to conserved linkage. Faust CJ, et al. Genomics, 1992 Aug. PMID 1354645
    3. Pulse-field linkage of the P3, G6pd and Cf-8 genes on the mouse X chromosome: demonstration of synteny at the physical level. Brockdorff N, et al. Nucleic Acids Res, 1989 Feb 25. PMID 2922282, Free PMC Article
    4. CpG islands of the X chromosome are gene associated. Alcalay M, et al. Nucleic Acids Res, 1988 Oct 25. PMID 3186440, Free PMC Article
    5. Linkage and sequence conservation of the X-linked genes DXS253E (P3) and DXS254E (GdX) in mouse and man. Filippi M, et al. Genomics, 1990 Jul. PMID 1973144

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Readthrough Gm44504

    Readthrough gene: Gm44504, Included gene: Ubl4a

    Homology

    Clone Names

    • MGC36271, MGC38638

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables bile acid:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to retinoic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    P3 protein
    Names
    protein P3
    solute carrier family 10, member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256104.1 → NP_001243033.1  P3 protein precursor

      See identical proteins and their annotated locations for NP_001243033.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK041958, AL807376, AW493539, BM939642, CN723057
      Consensus CDS
      CCDS30231.1
      UniProtKB/Swiss-Prot
      P21129, Q8QZR2
      UniProtKB/TrEMBL
      A0A158SIT6, J3JSA1
      Related
      ENSMUSP00000072818.5, ENSMUST00000073067.11
      Conserved Domains (1) summary
      TIGR00841
      Location:197 → 470
      bass; bile acid transporter

    2. NM_145406.2 → NP_663381.1  P3 protein precursor

      See identical proteins and their annotated locations for NP_663381.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK041958, AL807376, AW493539, BM939642
      Consensus CDS
      CCDS30231.1
      UniProtKB/Swiss-Prot
      P21129, Q8QZR2
      UniProtKB/TrEMBL
      A0A158SIT6, J3JSA1
      Related
      ENSMUSP00000045150.6, ENSMUST00000037967.6
      Conserved Domains (1) summary
      TIGR00841
      Location:197 → 470
      bass; bile acid transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      73412823..73416955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21129.2 GenPept UniProtKB/Swiss-Prot:P21129

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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