Cldn2 claudin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cldn2provided by MGI
Official Full Name: claudin 2provided by MGI
Primary source: MGI:MGI:1276110
See related: Ensembl:ENSMUSG00000047230 AllianceGenome:MGI:1276110
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The knockout mice lacking this gene display normal appearance, activity, growth and behavior, but are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules. The proteins encoded by this gene and another family member Cldn12 are also critical for vitamin D-dependent Ca2+ absorption between enterocytes. [provided by RefSeq, Aug 2010]
Expression: Biased expression in kidney adult (RPKM 78.3), genital fat pad adult (RPKM 58.9) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: X F1; X 61.35 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (138701552..138712135)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (139800808..139811386)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis.
Title: Claudin-2 upregulation enhances intestinal permeability, immune activation, dysbiosis, and mortality in sepsis.
Claudin-2 protects against colitis-associated cancer by promoting colitis-associated mucosal healing.
Title: Claudin-2 protects against colitis-associated cancer by promoting colitis-associated mucosal healing.
P62/SQSTM1 binds with claudin-2 to target for selective autophagy in stressed intestinal epithelium.
Title: P62/SQSTM1 binds with claudin-2 to target for selective autophagy in stressed intestinal epithelium.
Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis.
Title: Claudin-2 and claudin-12 form independent, complementary pores required to maintain calcium homeostasis.
Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice.
Title: Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice.
Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease.
Title: Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease.
Caveolin 1 is Associated with Upregulated Claudin 2 in Necrotizing Enterocolitis.
Title: Caveolin 1 is Associated with Upregulated Claudin 2 in Necrotizing Enterocolitis.
CLDN-2 silencing reduces proliferation through RHOA-dependent up-regulation of P27KIP1.
Title: Claudin-2 suppresses GEF-H1, RHOA, and MRTF, thereby impacting proliferation and profibrotic phenotype of tubular cells.
results reveal that IL-22 increases intestinal epithelial permeability by upregulating Claudin-2 expression through the JAK/STAT pathway
Title: IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression.
claudin-2-null mice conserve sodium to the same extent as WT mice, even during profound dietary sodium depletion, as a result of the upregulation of transcellular Na-K-2Cl transport activity in the thick ascending limb of Henle
Title: Paracellular epithelial sodium transport maximizes energy efficiency in the kidney.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Markers

Cldn2 (e-PCR), detects polymorphism
- UniSTS:545918

RH125356 (e-PCR)
- UniSTS:162178

Cldn2 (e-PCR), detects polymorphism
- UniSTS:465376

Cldn2 (e-PCR), detects polymorphism
- UniSTS:495871

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables paracellular tight junction channel activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bicellular tight junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response in mucosa	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in paracellular transport	IDA Inferred from Direct Assay more info	PubMed
involved_in paracellular transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of bile acid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of intestinal D-glucose absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of intestinal lipid absorption	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in tight junction	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: claudin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.