Upk2 uroplakin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Upk2provided by MGI
Official Full Name: uroplakin 2provided by MGI
Primary source: MGI:MGI:98913
See related: Ensembl:ENSMUSG00000041523 AllianceGenome:MGI:98913
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UPII
Summary: Predicted to be involved in epithelial cell differentiation. Located in apical plasma membrane. Is active in apical plasma membrane urothelial plaque. Is expressed in Meckel's cartilage; bladder; and skeleton. Orthologous to human UPK2 (uroplakin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward bladder adult (RPKM 400.8) See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 24.84 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (44364012..44366064, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (44452715..44454767, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Conversely, repair of focal mucosal defects not only employs this mechanism, but in parallel host intermediate cell daughters expressing uroplakin 2 give rise to themselves and are also contributors to superficial cells in neotissues.
Title: Mode of Surgical Injury Influences the Source of Urothelial Progenitors during Bladder Defect Repair.
role of uroplakins in CO2 transport through urothelium
Title: Uroplakins do not restrict CO2 transport through urothelium.
The despites a lower level of expression, UPII maintain its plaque association in urothelial preneoplastic lesions.
Title: Expression and localization of four uroplakins in urothelial preneoplastic lesions.
Bladder-specific autoimmune response sufficient to induce inflammation and interstitial cystitis occurs in mice following immunization with recombinant murine UPK2.
Title: Autoimmunity to uroplakin II causes cystitis in mice: a novel model of interstitial cystitis.
structure of the major membrane protein complex from urinary bladder epithelial cells by cryo-electron crystallography
Title: Structure of the major membrane protein complex from urinary bladder epithelial cells by cryo-electron crystallography.
The UPII knockout abolished plaque formation, indicating that both uroplakin heterodimers (UPIa/II and UPIb/III or IIIb) are required for plaque assembly.
Title: Roles of uroplakins in plaque formation, umbrella cell enlargement, and urinary tract diseases.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:489108

Upk2 (e-PCR), detects polymorphism
- UniSTS:527018

AW491716 (e-PCR)
- UniSTS:179886

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in apical plasma membrane urothelial plaque	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: uroplakin-2

Names: UP2; uroplakin II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.