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    Fpr-rs3 formyl peptide receptor, related sequence 3 [ Mus musculus (house mouse) ]

    Gene ID: 14290, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fpr-rs3provided by MGI
    Official Full Name
    formyl peptide receptor, related sequence 3provided by MGI
    Primary source
    MGI:MGI:1278318
    See related
    Ensembl:ENSMUSG00000060701 AllianceGenome:MGI:1278318
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables N-formyl peptide receptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to amyloid-beta; and positive regulation of immune response. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Is expressed in accessory olfactory bulb; accessory olfactory bulb glomerular layer; vomeronasal organ; vomeronasal organ epithelium; and vomeronasal organ sensory epithelium. Orthologous to human FPR2 (formyl peptide receptor 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See Fpr-rs3 in Genome Data Viewer
    Location:
    17 A3.2; 17 11.4 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (20844108..20845139, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (20623846..20624877, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein polypeptide A pseudogene Neighboring gene vomeronasal 2, receptor 110 Neighboring gene predicted gene, 52311 Neighboring gene actin related protein 2/3 complex, subunit 2 pseudogene

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-formyl peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables N-formyl peptide receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables complement receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables scavenger receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in complement receptor mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in immune response-regulating cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of monocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of phagocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    formyl peptide receptor-related sequence 3
    Names
    N-formylpeptide receptor-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008040.2NP_032066.2  formyl peptide receptor-related sequence 3

      See identical proteins and their annotated locations for NP_032066.2

      Status: VALIDATED

      Source sequence(s)
      AC166351, BC134352
      Consensus CDS
      CCDS49989.1
      UniProtKB/Swiss-Prot
      A4IF56, E9QL30, O88537
      Related
      ENSMUSP00000071179.2, ENSMUST00000071189.2
      Conserved Domains (1) summary
      pfam00001
      Location:43297
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      20844108..20845139 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)