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    Btg4 BTG anti-proliferation factor 4 [ Mus musculus (house mouse) ]

    Gene ID: 56057, updated on 3-Dec-2024

    Summary

    Official Symbol
    Btg4provided by MGI
    Official Full Name
    BTG anti-proliferation factor 4provided by MGI
    Primary source
    MGI:MGI:1860140
    See related
    Ensembl:ENSMUSG00000032056 AllianceGenome:MGI:1860140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PC3B
    Summary
    Enables mRNA 3'-UTR binding activity. Acts upstream of or within maternal-to-zygotic transition of gene expression and negative regulation of mitotic cell cycle. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; early embryo; gonad; nasal cavity epithelium; and retina. Orthologous to human BTG4 (BTG anti-proliferation factor 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 2.3) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Btg4 in Genome Data Viewer
    Location:
    9 A5.3; 9 27.84 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (51013486..51031224)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (51102147..51119924)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene protein phosphatase 2, regulatory subunit A, beta Neighboring gene salt inducible kinase 2 Neighboring gene STARR-seq mESC enhancer starr_24123 Neighboring gene STARR-seq mESC enhancer starr_24124 Neighboring gene STARR-positive B cell enhancer ABC_E8290 Neighboring gene predicted gene, 32681 Neighboring gene layilin Neighboring gene STARR-seq mESC enhancer starr_24125 Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene microRNA 34b Neighboring gene microRNA 34c Neighboring gene predicted gene, 32742 Neighboring gene STARR-positive B cell enhancer ABC_E10544 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:50973591-50973879 Neighboring gene STARR-seq mESC enhancer starr_24126 Neighboring gene STARR-positive B cell enhancer ABC_E6731 Neighboring gene STARR-positive B cell enhancer ABC_E10545 Neighboring gene STARR-positive B cell enhancer ABC_E6732 Neighboring gene POU domain, class 2, associating factor 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein BTG4
    Names
    B cell translocation gene 4
    BTG family member 4
    protein PC3b

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401092.1NP_001388021.1  protein BTG4

      Status: VALIDATED

      Source sequence(s)
      AC119831
      UniProtKB/Swiss-Prot
      O70552, Q925T9
      UniProtKB/TrEMBL
      Q6NXZ4
      Related
      ENSMUSP00000149181.2, ENSMUST00000213680.2
    2. NM_019493.5NP_062366.2  protein BTG4

      See identical proteins and their annotated locations for NP_062366.2

      Status: VALIDATED

      Source sequence(s)
      AC119831
      Consensus CDS
      CCDS40629.1
      UniProtKB/Swiss-Prot
      O70552, Q925T9
      UniProtKB/TrEMBL
      Q6NXZ4
      Related
      ENSMUSP00000110074.3, ENSMUST00000114431.4
      Conserved Domains (1) summary
      pfam07742
      Location:1114
      BTG; BTG family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      51013486..51031224
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510500.4XP_006510563.1  protein BTG4 isoform X1

      See identical proteins and their annotated locations for XP_006510563.1

      UniProtKB/Swiss-Prot
      O70552, Q925T9
      UniProtKB/TrEMBL
      Q6NXZ4
      Conserved Domains (1) summary
      pfam07742
      Location:1114
      BTG; BTG family
    2. XM_006510499.4XP_006510562.1  protein BTG4 isoform X1

      See identical proteins and their annotated locations for XP_006510562.1

      UniProtKB/Swiss-Prot
      O70552, Q925T9
      UniProtKB/TrEMBL
      Q6NXZ4
      Conserved Domains (1) summary
      pfam07742
      Location:1114
      BTG; BTG family
    3. XM_017313490.2XP_017168979.1  protein BTG4 isoform X1

      UniProtKB/Swiss-Prot
      O70552, Q925T9
      UniProtKB/TrEMBL
      Q6NXZ4
      Conserved Domains (1) summary
      pfam07742
      Location:1114
      BTG; BTG family
    4. XM_006510501.4XP_006510564.1  protein BTG4 isoform X1

      See identical proteins and their annotated locations for XP_006510564.1

      UniProtKB/Swiss-Prot
      O70552, Q925T9
      UniProtKB/TrEMBL
      Q6NXZ4
      Conserved Domains (1) summary
      pfam07742
      Location:1114
      BTG; BTG family
    5. XM_006510502.3XP_006510565.1  protein BTG4 isoform X1

      See identical proteins and their annotated locations for XP_006510565.1

      UniProtKB/Swiss-Prot
      O70552, Q925T9
      UniProtKB/TrEMBL
      Q6NXZ4
      Conserved Domains (1) summary
      pfam07742
      Location:1114
      BTG; BTG family