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    Slc38a4 solute carrier family 38, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 69354, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc38a4provided by MGI
    Official Full Name
    solute carrier family 38, member 4provided by MGI
    Primary source
    MGI:MGI:1916604
    See related
    Ensembl:ENSMUSG00000022464 AllianceGenome:MGI:1916604
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ata3; SNAT4; mATA3; mNAT3; 1110012E16Rik; 1700012A18Rik
    Summary
    Enables L-arginine transmembrane transporter activity and neutral L-amino acid:sodium symporter activity. Involved in L-alanine import across plasma membrane and L-arginine transmembrane transport. Predicted to be located in microvillus membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; extraembryonic component; genitourinary system; gut; and liver. Orthologous to human SLC38A4 (solute carrier family 38 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 139.1), placenta adult (RPKM 78.5) and 6 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc38a4 in Genome Data Viewer
    Location:
    15 F1; 15 52.77 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (96892701..96953837, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (96994816..97055956, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39603 Neighboring gene predicted gene, 32677 Neighboring gene ribosomal protein L10A, pseudogene 3 Neighboring gene STARR-positive B cell enhancer ABC_E5511 Neighboring gene STARR-seq mESC enhancer starr_39604 Neighboring gene STARR-seq mESC enhancer starr_39606 Neighboring gene STARR-seq mESC enhancer starr_39607 Neighboring gene STARR-seq mESC enhancer starr_39610 Neighboring gene predicted gene, 32840 Neighboring gene STARR-seq mESC enhancer starr_39612 Neighboring gene predicted gene, 32789 Neighboring gene predicted gene, 32733

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6)  1 citation
    • Gene trapped (2) 
    • Targeted (2) 

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables L-arginine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables alanine:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables alanine:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amino acid:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables neutral L-amino acid:sodium symporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables neutral L-amino acid:sodium symporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables neutral L-amino acid:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in L-alanine import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in L-alanine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-alanine import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in L-alanine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in L-arginine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neutral amino acid transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neutral amino acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in microvillus membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microvillus membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    sodium-coupled neutral amino acid transporter 4
    Names
    Na(+)-coupled neutral amino acid transporter 4
    amino acid transporter A3
    system A amino acid transporter 3
    system-N amino acid transporter 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358058.1NP_001344987.1  sodium-coupled neutral amino acid transporter 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC113177, AC158560
      Consensus CDS
      CCDS27779.1
      UniProtKB/Swiss-Prot
      Q3TEZ9, Q3TJ89, Q3TPL5, Q8R1S9, Q8VIE7
      Related
      ENSMUSP00000154818.2, ENSMUST00000230086.2
      Conserved Domains (1) summary
      cl00456
      Location:75535
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. NM_001358059.1NP_001344988.1  sodium-coupled neutral amino acid transporter 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC113177, AC158560
      Consensus CDS
      CCDS27779.1
      UniProtKB/Swiss-Prot
      Q3TEZ9, Q3TJ89, Q3TPL5, Q8R1S9, Q8VIE7
      Related
      ENSMUSP00000127676.2, ENSMUST00000166223.2
      Conserved Domains (1) summary
      cl00456
      Location:75535
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    3. NM_001358060.1NP_001344989.1  sodium-coupled neutral amino acid transporter 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AC113177, AC158560
      Consensus CDS
      CCDS27779.1
      UniProtKB/Swiss-Prot
      Q3TEZ9, Q3TJ89, Q3TPL5, Q8R1S9, Q8VIE7
      Related
      ENSMUSP00000155158.2, ENSMUST00000231039.2
      Conserved Domains (1) summary
      cl00456
      Location:75535
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    4. NM_027052.3NP_081328.2  sodium-coupled neutral amino acid transporter 4

      See identical proteins and their annotated locations for NP_081328.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
      Source sequence(s)
      AK051023
      Consensus CDS
      CCDS27779.1
      UniProtKB/Swiss-Prot
      Q3TEZ9, Q3TJ89, Q3TPL5, Q8R1S9, Q8VIE7
      Related
      ENSMUSP00000023101.4, ENSMUST00000023101.10
      Conserved Domains (1) summary
      cl00456
      Location:75535
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      96892701..96953837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521350.5XP_006521413.1  sodium-coupled neutral amino acid transporter 4 isoform X1

      See identical proteins and their annotated locations for XP_006521413.1

      UniProtKB/Swiss-Prot
      Q3TEZ9, Q3TJ89, Q3TPL5, Q8R1S9, Q8VIE7
      Conserved Domains (1) summary
      cl00456
      Location:75535
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    2. XM_006521351.4XP_006521414.1  sodium-coupled neutral amino acid transporter 4 isoform X1

      See identical proteins and their annotated locations for XP_006521414.1

      UniProtKB/Swiss-Prot
      Q3TEZ9, Q3TJ89, Q3TPL5, Q8R1S9, Q8VIE7
      Conserved Domains (1) summary
      cl00456
      Location:75535
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain