Mnat1 menage a trois 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mnat1provided by MGI
Official Full Name: menage a trois 1provided by MGI
Primary source: MGI:MGI:106207
See related: Ensembl:ENSMUSG00000021103 AllianceGenome:MGI:106207
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P36; MAT1; E130115E11Rik
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity and metal ion binding activity. Acts upstream of or within several processes, including adult heart development; response to calcium ion; and ventricular system development. Predicted to be located in nucleoplasm. Predicted to be part of CAK-ERCC2 complex; RNA polymerase II transcription regulator complex; and cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and hemolymphoid system gland. Orthologous to human MNAT1 (MNAT1 component of CDK activating kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 6.1), limb E14.5 (RPKM 4.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 30.37 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (73158957..73320762)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (73112185..73273988)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAT1 serves as a promoter in the lung metastasis of osteosarcoma through increasing AKT1 expression.
Title: MAT1 facilitates the lung metastasis of osteosarcoma through upregulation of AKT1 expression.
Deletion of the TFIIH kinase subunit Mat1 in mouse fibroblasts leads to dramatically reduced RNA polymerase II Ser5 phosphorylation.
Title: Requirement of TFIIH kinase subunit Mat1 for RNA Pol II C-terminal domain Ser5 phosphorylation, transcription and mRNA turnover.
investigated the function of the Cdk7.cyclin H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells
Title: Functional analysis of the Cdk7.cyclin H.Mat1 complex in mouse embryonic stem cells and embryos.
study found that Mat1 and Cdk7 levels are undetectable in adipose tissues in vivo and downregulated during adipogenesis
Title: Mat1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipocyte differentiation.
This study demonstrates a requirement for MAT1 in the operation of PGC-1 coactivators that control cell metabolism.
Title: Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Mnat1 (e-PCR), detects polymorphism
- UniSTS:143888

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

PMC125252P1 (e-PCR)
- UniSTS:270484

AW743876 (e-PCR)
- UniSTS:208818

NoName (e-PCR)
- UniSTS:493235

RH118349 (e-PCR)
- UniSTS:160980

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at RNA polymerase II promoter	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CAK-ERCC2 complex	IEA Inferred from Electronic Annotation more info
part_of CAK-ERCC2 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFIIH core complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIH core complex	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFIIH holo complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIH holo complex	ISO Inferred from Sequence Orthology more info
part_of transcription factor TFIIH holo complex	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription factor TFIIK complex	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIK complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: CDK-activating kinase assembly factor MAT1

Names: CDK7/cyclin-H assembly factor; RING finger protein MAT1; p35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008612.2 → NP_032638.2 CDK-activating kinase assembly factor MAT1

See identical proteins and their annotated locations for NP_032638.2

Status: VALIDATED

Source sequence(s)

AK155859, AK157721

Consensus CDS

CCDS49087.1

UniProtKB/Swiss-Prot

P51949, Q14BS9, Q3TZP0, Q9D8A0, Q9D8D2

Related

ENSMUSP00000021523.7, ENSMUST00000021523.7

Conserved Domains (2) summary

TIGR00570
Location:1 → 308

cdk7; CDK-activating kinase assembly factor MAT1

cl17238
Location:3 → 50

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...