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    D1Pas1 DNA segment, Chr 1, Pasteur Institute 1 [ Mus musculus (house mouse) ]

    Gene ID: 110957, updated on 9-Dec-2024

    Summary

    Official Symbol
    D1Pas1provided by MGI
    Official Full Name
    DNA segment, Chr 1, Pasteur Institute 1provided by MGI
    Primary source
    MGI:MGI:91842
    See related
    Ensembl:ENSMUSG00000039224 AllianceGenome:MGI:91842
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pl10; DDX3XL
    Summary
    Predicted to enable several functions, including helicase activity; nucleic acid binding activity; and ribonucleoside triphosphate phosphatase activity. Acts upstream of or within spermatogenesis. Predicted to be located in several cellular components, including centrosome; cytoplasmic stress granule; and nucleoplasm. Predicted to be part of cytosolic small ribosomal subunit and eukaryotic translation initiation factor 3 complex. Predicted to be active in P granule and nucleus. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; hemolymphoid system; and liver and biliary system. Human ortholog(s) of this gene implicated in colorectal cancer and syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See D1Pas1 in Genome Data Viewer
    Location:
    1 H5; 1 90.09 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (186699613..186702824)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (186967416..186970627)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39732 Neighboring gene predicted gene, 39731 Neighboring gene STARR-seq mESC enhancer starr_03363 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene proteasome (prosome, macropain) subunit, beta type 4 pseudogene Neighboring gene spermatogenesis associated 17 Neighboring gene predicted gene 15509

    Genomic regions, transcripts, and products

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables CTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA stem-loop binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA strand annealing activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic initiation factor 4E binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables gamma-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 5'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables poly(A) binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribonucleoside triphosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosomal small subunit binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation initiation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in RNA secondary structure unwinding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to arsenic-containing substance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to osmotic stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytosolic ribosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in gamete generation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within pachytene IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of toll-like receptor 7 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of toll-like receptor 8 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type I interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in P granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytosolic small ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    part_of eukaryotic translation initiation factor 3 complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    putative ATP-dependent RNA helicase Pl10
    NP_149068.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_033077.3NP_149068.1  putative ATP-dependent RNA helicase Pl10

      See identical proteins and their annotated locations for NP_149068.1

      Status: VALIDATED

      Source sequence(s)
      AK029542, BG070553
      Consensus CDS
      CCDS15603.1
      UniProtKB/Swiss-Prot
      P16381
      UniProtKB/TrEMBL
      B9EIA2
      Related
      ENSMUSP00000035261.2, ENSMUST00000045108.2
      Conserved Domains (3) summary
      smart00487
      Location:194417
      DEXDc; DEAD-like helicases superfamily
      cd00268
      Location:181403
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam00271
      Location:425535
      Helicase_C; Helicase conserved C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      186699613..186702824
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)