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    Pld6 phospholipase D family member 6 [ Mus musculus (house mouse) ]

    Gene ID: 194908, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pld6provided by MGI
    Official Full Name
    phospholipase D family member 6provided by MGI
    Primary source
    MGI:MGI:2687283
    See related
    Ensembl:ENSMUSG00000043648 AllianceGenome:MGI:2687283
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zuc; Gm10; mZuc; mitoPLD; 4933433K01Rik
    Summary
    Enables identical protein binding activity. Involved in germ cell development; meiotic cell cycle; and piRNA processing. Located in mitochondrial outer membrane. Orthologous to human PLD6 (phospholipase D family member 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 34.0), stomach adult (RPKM 4.9) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Pld6 in Genome Data Viewer
    Location:
    11 B1.3; 11 37.79 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (59674719..59678483, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (59783893..59787657, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myosin phosphatase Rho interacting protein Neighboring gene RIKEN cDNA 1700007J10 gene Neighboring gene predicted gene, 51899 Neighboring gene folliculin Neighboring gene STARR-seq mESC enhancer starr_29631 Neighboring gene predicted gene 16062 Neighboring gene COP9 signalosome subunit 3 Neighboring gene predicted gene, 51946

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA endonuclease activity, producing 5'-phosphomonoesters IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cardiolipin hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cardiolipin hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phospholipase D activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in P granule organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in piRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in piRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mitochondrial cardiolipin hydrolase
    Names
    choline phosphatase 6
    mitochondrial phospholipase
    novel Phospholipase D Active site motif-containing protein
    phosphatidylcholine-hydrolyzing phospholipase D6
    phospholipase D6
    protein zucchini homolog
    NP_001277212.1
    NP_898962.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290283.1NP_001277212.1  mitochondrial cardiolipin hydrolase isoform a

      See identical proteins and their annotated locations for NP_001277212.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AL596204, AW554531, BC119245
      Consensus CDS
      CCDS70199.1
      UniProtKB/Swiss-Prot
      B7ZN71, Q3UTA3, Q5SWZ9, Q8BVM0
      Related
      ENSMUSP00000115503.2, ENSMUST00000125307.2
      Conserved Domains (2) summary
      cd09171
      Location:92203
      PLDc_vPLD6_like; Catalytic domain of vertebrate phospholipase D6 and similar proteins
      pfam13091
      Location:93203
      PLDc_2; PLD-like domain
    2. NM_183139.2NP_898962.2  mitochondrial cardiolipin hydrolase isoform b

      See identical proteins and their annotated locations for NP_898962.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
      Source sequence(s)
      AL596204, AW554531, BC119245
      UniProtKB/Swiss-Prot
      Q5SWZ9
      Related
      ENSMUST00000051493.8
      Conserved Domains (1) summary
      cl15239
      Location:92138
      PLDc_SF; Catalytic domain of phospholipase D superfamily proteins

    RNA

    1. NR_110894.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AL596204, AW554531, CK137362

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      59674719..59678483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)