Plk5 polo like kinase 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plk5provided by MGI
Official Full Name: polo like kinase 5provided by MGI
Primary source: MGI:MGI:3026984
See related: Ensembl:ENSMUSG00000035486 AllianceGenome:MGI:3026984
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6330514A18Rik
Summary: Predicted to enable ATP binding activity and metal ion binding activity. Involved in several processes, including defense response to tumor cell; positive regulation of neuron projection development; and regulation of G1/S transition of mitotic cell cycle. Located in nucleolus. Is expressed in several structures, including central nervous system; eye; and ovary. Orthologous to human PLK5 (polo like kinase 5 (inactive)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 19.2), cortex adult (RPKM 4.7) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (80192293..80201323)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (80356459..80365489)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plk5 is mostly expressed in the brain of both mice and humans, and it modulates the formation of neuritic processes upon stimulation of the brain-derived neurotrophic factor (BDNF)/nerve growth factor (NGF)-Ras pathway in neurons.
Title: Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression.
DNA and protein sequence analyses show that Plk5 shares more similarities with Plk2 and Plk3 than with Plk1 and Plk4.
Title: The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
NOT enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in defense response to tumor cell	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: inactive serine/threonine-protein kinase PLK5

Names: serine/threonine-protein kinase PLK5

NP_001334053.1

EC 2.7.11.21

NP_898975.2

EC 2.7.11.21

XP_006513561.1

EC 2.7.11.21

XP_006513563.1

EC 2.7.11.21

XP_006513564.1

EC 2.7.11.21

XP_006513565.1

EC 2.7.11.21

XP_030100882.1

EC 2.7.11.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347124.2 → NP_001334053.1 inactive serine/threonine-protein kinase PLK5 isoform 2

Status: VALIDATED

Source sequence(s)

AC152062

Consensus CDS

CCDS83729.1

UniProtKB/Swiss-Prot

Q0VGS4, Q4FZD7, Q8C096

Related

ENSMUSP00000100988.2, ENSMUST00000105351.2
NM_001433556.1 → NP_001420485.1 inactive serine/threonine-protein kinase PLK5 isoform 3

Status: VALIDATED

Source sequence(s)

AC152062
NM_001433557.1 → NP_001420486.1 inactive serine/threonine-protein kinase PLK5 isoform 4

Status: VALIDATED

Source sequence(s)

AC152062
NM_001433558.1 → NP_001420487.1 inactive serine/threonine-protein kinase PLK5 isoform 5

Status: VALIDATED

Source sequence(s)

AC152062
NM_001433559.1 → NP_001420488.1 inactive serine/threonine-protein kinase PLK5 isoform 6

Status: VALIDATED

Source sequence(s)

AC152062
NM_183152.5 → NP_898975.2 inactive serine/threonine-protein kinase PLK5 isoform 1

See identical proteins and their annotated locations for NP_898975.2

Status: VALIDATED

Source sequence(s)

AC152062

Consensus CDS

CCDS35980.1

UniProtKB/TrEMBL

G3X967

Related

ENSMUSP00000044400.9, ENSMUST00000039836.15

Conserved Domains (3) summary

smart00220
Location:27 → 283

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13118
Location:414 → 501

POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd14099
Location:25 → 283

STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

80192293..80201323

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006513498.1 → XP_006513561.1 inactive serine/threonine-protein kinase PLK5 isoform X1

Conserved Domains (2) summary

cd13118
Location:423 → 510

POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd14099
Location:25 → 292

STKc_PLK; Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases
XM_006513501.1 → XP_006513564.1 inactive serine/threonine-protein kinase PLK5 isoform X3

Conserved Domains (2) summary

cd13118
Location:371 → 458

POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cl21453
Location:25 → 240

PKc_like; Protein Kinases, catalytic domain
XM_006513500.5 → XP_006513563.1 inactive serine/threonine-protein kinase PLK5 isoform X2

Conserved Domains (2) summary

cd13118
Location:377 → 464

POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cl21453
Location:1 → 246

PKc_like; Protein Kinases, catalytic domain
XM_030245022.2 → XP_030100882.1 inactive serine/threonine-protein kinase PLK5 isoform X5

Conserved Domains (2) summary

cd13118
Location:325 → 412

POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cl21453
Location:1 → 194

PKc_like; Protein Kinases, catalytic domain
XM_006513502.4 → XP_006513565.1 inactive serine/threonine-protein kinase PLK5 isoform X4

Conserved Domains (2) summary

cd13118
Location:356 → 443

POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cl21453
Location:5 → 225

PKc_like; Protein Kinases, catalytic domain