Arid2 AT-rich interaction domain 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arid2provided by MGI
Official Full Name: AT-rich interaction domain 2provided by MGI
Primary source: MGI:MGI:1924294
See related: Ensembl:ENSMUSG00000033237 AllianceGenome:MGI:1924294
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BAF200; zipzap/p200; 1700124K17Rik; 4432409D24Rik
Summary: Predicted to enable DNA binding activity and metal ion binding activity. Acts upstream of or within embryonic organ development; heart development; and homeostatic process. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of SWI/SNF complex and transcription regulator complex. Is expressed in central nervous system; early conceptus; and genitourinary system. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 6; colorectal cancer; and hepatocellular carcinoma. Orthologous to human ARID2 (AT-rich interaction domain 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 32.0), thymus adult (RPKM 22.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 52.37 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (96185403..96303344)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (96287522..96405463)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ARID2 mitigates hepatic steatosis via promoting the ubiquitination of JAK2.
Title: ARID2 mitigates hepatic steatosis via promoting the ubiquitination of JAK2.
Downregulation of AT-rich interaction domain 2 underlies natural killer cell dysfunction in oral squamous cell carcinoma.
Title: Downregulation of AT-rich interaction domain 2 underlies natural killer cell dysfunction in oral squamous cell carcinoma.
ARID2 Deficiency Correlates with the Response to Immune Checkpoint Blockade in Melanoma.
Title: ARID2 Deficiency Correlates with the Response to Immune Checkpoint Blockade in Melanoma.
ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to chemotherapy in lung cancer.
Title: ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to chemotherapy in lung cancer.
Arid2 regulates hematopoietic stem cell differentiation in normal hematopoiesis.
Title: Arid2 regulates hematopoietic stem cell differentiation in normal hematopoiesis.
ARID2 knockout promotes pulmonary metastasis in different HCC mouse models.
Title: Chromatin remodeling factor ARID2 suppresses hepatocellular carcinoma metastasis via DNMT1-Snail axis.
Increased Arid2-IR likely contributes to ECM production in DKD and that Egr1 promotes ECM production in DKD.
Title: Early growth response protein-1 upregulates long noncoding RNA Arid2-IR to promote extracellular matrix production in diabetic kidney disease.
Baf200 deficiency accelerates the progression of MLL-AF9-induced leukemia.
Title: The chromatin remodeling subunit Baf200 promotes normal hematopoiesis and inhibits leukemogenesis.
a critical role for ARID2-containing complexes in promoting osteoblast differentiation and supports a view that the PBAF subset of SWI/SNF contributes importantly to maintaining cellular identity and activating tissue-specific gene expression.
Title: Essential role of ARID2 protein-containing SWI/SNF complex in tissue-specific gene expression.
zipzap may serve as a transcription co-activator for the regulation of cardiac gene expression
Title: Zipzap/p200 is a novel zinc finger protein contributing to cardiac gene regulation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_21821-21822:1025098890:1 (e-PCR)
- UniSTS:268639

ARID2_3730 (e-PCR)
- UniSTS:462036

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription factor binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within circulatory system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within coronary artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic organ development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostatic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in nucleosome disassembly	IEA Inferred from Electronic Annotation more info
involved_in nucleosome disassembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast differentiation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed
involved_in regulation of G0 to G1 transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of mitotic metaphase/anaphase transition	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of nucleotide-excision repair	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of RSC-type complex	NAS Non-traceable Author Statement more info	PubMed
part_of SWI/SNF complex	IEA Inferred from Electronic Annotation more info
part_of SWI/SNF complex	ISO Inferred from Sequence Orthology more info
part_of SWI/SNF superfamily-type complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SWI/SNF superfamily-type complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	NAS Non-traceable Author Statement more info	PubMed
located_in kinetochore	NAS Non-traceable Author Statement more info	PubMed
located_in nuclear matrix	NAS Non-traceable Author Statement more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: AT-rich interactive domain-containing protein 2

Names: ARID domain-containing protein 2; AT rich interactive domain 2 (ARID, RFX-like); AT rich interactive domain 2 (Arid-rfx like); BRG1-associated factor 200; zinc finger protein with activation potential; zipzap

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175251.4 → NP_780460.3 AT-rich interactive domain-containing protein 2

Status: VALIDATED

Source sequence(s)

AC133578, AK007269, AK077366, BU056807, CA749551, CK781204, CV559640

Consensus CDS

CCDS37185.2

UniProtKB/Swiss-Prot

E9Q7E2

Related

ENSMUSP00000093969.5, ENSMUST00000096250.5

Conserved Domains (4) summary

pfam01388
Location:19 → 101

ARID; ARID/BRIGHT DNA binding domain

pfam02257
Location:521 → 601

RFX_DNA_binding; RFX DNA-binding domain

cl26464
Location:603 → 910

Atrophin-1; Atrophin-1 family

cl26809
Location:1278 → 1575

Sec23_BS; Sec23/Sec24 beta-sandwich domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

96185403..96303344

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159626.1 → XP_036015519.1 AT-rich interactive domain-containing protein 2 isoform X1

Conserved Domains (3) summary

PTZ00395
Location:1129 → 1426

PTZ00395; Sec24-related protein; Provisional

pfam02257
Location:372 → 452

RFX_DNA_binding; RFX DNA-binding domain

cl41773
Location:527 → 1003

SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4