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    CIT citron rho-interacting serine/threonine kinase [ Homo sapiens (human) ]

    Gene ID: 11113, updated on 10-Dec-2024

    Summary

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    Official Symbol
    CITprovided by HGNC
    Official Full Name
    citron rho-interacting serine/threonine kinaseprovided by HGNC
    Primary source
    HGNC:HGNC:1985
    See related
    Ensembl:ENSG00000122966 MIM:605629; AllianceGenome:HGNC:1985
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CITK; CRIK; STK21; MCPH17
    Summary
    This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
    Expression
    Broad expression in brain (RPKM 9.1), testis (RPKM 3.2) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CIT in Genome Data Viewer
    Location:
    12q24.23
    Exon count:
    51
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (119685791..119877320, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (119673075..119864647, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120123596..120315124, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370027 Neighboring gene transmembrane protein 233 Neighboring gene RN7SK pseudogene 197 Neighboring gene GATA motif-containing MPRA enhancer 88 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120106633-120107268 Neighboring gene uncharacterized LOC124903033 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120115207-120115708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120115709-120116208 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:120117012-120118211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120125555-120126425 Neighboring gene protein kinase AMP-activated non-catalytic subunit beta 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:120185956-120187155 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120192166-120192349 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120197803-120197989 Neighboring gene microRNA 1178 Neighboring gene NANOG hESC enhancer GRCh37_chr12:120213039-120213640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120242131-120242682 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:120306702-120307901 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7118 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4931 Neighboring gene uncharacterized LOC112268087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7119 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120423527-120423708 Neighboring gene ribosomal protein L35a pseudogene 30 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120426711-120427684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4932 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120427685-120428656 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120431757-120431860 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7120 Neighboring gene BICD family like cargo adaptor 1 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [Mechanism Underlying Increased Expression of a Member of the Serine/Threonine Kinase Family (Citron kinase) Induced by HIV-1 Infection]. Ding J, et al. Bing Du Xue Bao, 2015 Jul. PMID 26524911
    2. Down-regulation of CIT can inhibit the growth of human bladder cancer cells. Liu Z, et al. Biomed Pharmacother, 2020 Apr. PMID 31972359
    3. Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma. Sahin I, et al. Blood Adv, 2019 Apr 9. PMID 30940634, Free PMC Article
    4. Citron kinase (CIT-K) promotes aggressiveness and tumorigenesis of breast cancer cells in vitro and in vivo: preliminary study of the underlying mechanism. Meng D, et al. Clin Transl Oncol, 2019 Jul. PMID 30565087
    5. Mutations in Citron Kinase Cause Recessive Microlissencephaly with Multinucleated Neurons. Harding BN, et al. Am J Hum Genet, 2016 Aug 4. PMID 27453579, Free PMC Article

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase.
      Title: Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase.
    2. Novel circRNA_0071196/miRNA19b3p/CIT axis is associated with proliferation and migration of bladder cancer.
      Title: Novel circRNA_0071196/miRNA‑19b‑3p/CIT axis is associated with proliferation and migration of bladder cancer.
    3. Down-regulation of CIT can inhibit the growth of human bladder cancer cells.
      Title: Down-regulation of CIT can inhibit the growth of human bladder cancer cells.
    4. gene expression profile data set showed that MM patients with high CIT gene expression had significantly worse overall survival compared with MM patients with low CIT gene expression. CIT silencing in MM cell lines induced cytokinesis failure and resulted in decreased MM cell proliferation in vitro and in vivo.
      Title: Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma.
    5. CIT-K overexpression is associated with breast cancer.
      Title: Citron kinase (CIT-K) promotes aggressiveness and tumorigenesis of breast cancer cells in vitro and in vivo: preliminary study of the underlying mechanism.
    6. CITK deletion decreased tumor growth and increased overall survival in these mice, with no apparent side effects. These results suggest that CITK can be a useful molecular target for medulloblastoma treatment.
      Title: Inactivation of Citron Kinase Inhibits Medulloblastoma Progression by Inducing Apoptosis and Cell Senescence.
    7. in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity.
      Title: ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.
    8. Control of abscission requires Eph kinase activity, and Src and citron kinase (CitK) are downstream effectors in the Eph-induced signal transduction cascade
      Title: Eph-mediated tyrosine phosphorylation of citron kinase controls abscission.
    9. The striking phenotypic overlap between CIT-mutated individuals and the knockout mice and rats that are specifically deficient in the kinase domain supports the proposed causal link between CIT mutation and primary microcephaly in humans.
      Title: Mutations in CIT, encoding citron rho-interacting serine/threonine kinase, cause severe primary microcephaly in humans.
    10. Splice site variant in CIT, identified in this study, is predicted to abolish splice donor site. cDNA sequence of an affected individual showed retention of an intron next to the splice donor site. The study, presented here, revealed the first variant in the CIT causing Autosomal recessive primary microcephaly in the family.
      Title: CIT, a gene involved in neurogenic cytokinesis, is mutated in human primary microcephaly.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Microcephaly 17, primary, autosomal recessive
    MedGen: C4310723 OMIM: 617090 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    HIV-1 replication is enhanced by CIT expression, which is dependent on NEDD4L expression as shown through siRNA knockdown of NEDD4L PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag polyubiquitination is enhanced by CIT (citron kinase) PubMed
    gag HIV-1 Gag interacts with the zinc finger, RhoA-binding, and leucine zipper domains of CIT (citron kinase) in HEK293T cells PubMed
    gag Ectopic expression of citron kinase leads to the formation of cytoplasmic structures containing citron kinase and HIV-1 Gag proteins PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0949

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables PDZ domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables scaffold protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in generation of neurons ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    citron Rho-interacting kinase
    Names
    citron (rho-interacting, serine/threonine kinase 21)
    serine/threonine kinase 21
    serine/threonine-protein kinase 21
    NP_001193928.1
    NP_009105.1
    XP_006719269.1
    XP_011536085.1
    XP_011536086.1
    XP_011536087.1
    XP_011536089.1
    XP_011536090.1
    XP_011536091.1
    XP_011536092.1
    XP_011536093.1
    XP_016874224.1
    XP_016874225.1
    XP_016874226.1
    XP_047284090.1
    XP_054226823.1
    XP_054226824.1
    XP_054226825.1
    XP_054226826.1
    XP_054226827.1
    XP_054226828.1
    XP_054226829.1
    XP_054226830.1
    XP_054226831.1
    XP_054226832.1
    XP_054226833.1
    XP_054226834.1
    XP_054226835.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029792.2 RefSeqGene

      Range
      5000..196529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001206999.2 → NP_001193928.1  citron Rho-interacting kinase isoform 1

      See identical proteins and their annotated locations for NP_001193928.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC004813, AY257469, AY681966
      Consensus CDS
      CCDS55891.1
      UniProtKB/Swiss-Prot
      O14578
      Related
      ENSP00000376306.2, ENST00000392521.7
      Conserved Domains (6) summary
      smart00036
      Location:1635 → 1931
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:97 → 360
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:474 → 1335
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:1405 → 1453
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05601
      Location:95 → 422
      STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
      pfam00169
      Location:1486 → 1605
      PH; PH domain

    2. NM_007174.3 → NP_009105.1  citron Rho-interacting kinase isoform 2

      See identical proteins and their annotated locations for NP_009105.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC004813, AY257469, AY681966
      Consensus CDS
      CCDS9192.1
      UniProtKB/Swiss-Prot
      O14578, Q2M5E1, Q6XUH8, Q86UQ9, Q9UPZ7
      UniProtKB/TrEMBL
      H7BYJ3
      Related
      ENSP00000261833.7, ENST00000261833.11
      Conserved Domains (7) summary
      smart00036
      Location:1593 → 1889
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:97 → 360
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:558 → 844
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      COG4942
      Location:1083 → 1365
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:1363 → 1411
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05601
      Location:95 → 422
      STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
      pfam00169
      Location:1444 → 1563
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      119685791..119877320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537788.2 → XP_011536090.1  citron Rho-interacting kinase isoform X10

      UniProtKB/TrEMBL
      H7BYJ3
      Conserved Domains (7) summary
      smart00036
      Location:1578 → 1874
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:97 → 360
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:558 → 844
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      COG4942
      Location:1083 → 1350
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:1348 → 1396
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05601
      Location:95 → 422
      STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
      pfam00169
      Location:1429 → 1548
      PH; PH domain

    2. XM_011537787.2 → XP_011536089.1  citron Rho-interacting kinase isoform X9

      See identical proteins and their annotated locations for XP_011536089.1

      UniProtKB/TrEMBL
      H7BYJ3
      Conserved Domains (7) summary
      smart00036
      Location:1578 → 1874
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:97 → 360
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:558 → 844
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      COG4942
      Location:1083 → 1350
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:1348 → 1396
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05601
      Location:95 → 422
      STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
      pfam00169
      Location:1429 → 1548
      PH; PH domain

    3. XM_047428134.1 → XP_047284090.1  citron Rho-interacting kinase isoform X8

      UniProtKB/TrEMBL
      H7BYJ3

    4. XM_017018737.2 → XP_016874226.1  citron Rho-interacting kinase isoform X7

    5. XM_006719206.3 → XP_006719269.1  citron Rho-interacting kinase isoform X6

      Conserved Domains (6) summary
      smart00036
      Location:1620 → 1916
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:97 → 360
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:474 → 1320
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:1390 → 1438
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05601
      Location:95 → 422
      STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
      pfam00169
      Location:1471 → 1590
      PH; PH domain

    6. XM_017018736.2 → XP_016874225.1  citron Rho-interacting kinase isoform X5

    7. XM_011537785.2 → XP_011536087.1  citron Rho-interacting kinase isoform X3

      Conserved Domains (6) summary
      smart00036
      Location:1635 → 1931
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:97 → 360
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:474 → 1320
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:1390 → 1438
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05601
      Location:95 → 422
      STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
      pfam00169
      Location:1471 → 1590
      PH; PH domain

    8. XM_017018735.2 → XP_016874224.1  citron Rho-interacting kinase isoform X4

    9. XM_011537784.2 → XP_011536086.1  citron Rho-interacting kinase isoform X2

      Conserved Domains (5) summary
      smart00109
      Location:1405 → 1453
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00036
      Location:1650 → 1946
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00233
      Location:1486 → 1605
      PH; Pleckstrin homology domain
      COG1196
      Location:474 → 1335
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd05601
      Location:95 → 422
      STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase

    10. XM_011537783.2 → XP_011536085.1  citron Rho-interacting kinase isoform X1

      Conserved Domains (6) summary
      smart00036
      Location:1650 → 1946
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:97 → 360
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:474 → 1335
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:1405 → 1453
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd05601
      Location:95 → 422
      STKc_CRIK; Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase
      pfam00169
      Location:1486 → 1605
      PH; PH domain

    11. XM_011537790.2 → XP_011536092.1  citron Rho-interacting kinase isoform X11

      See identical proteins and their annotated locations for XP_011536092.1

      UniProtKB/TrEMBL
      A0A7I2V692
      Conserved Domains (9) summary
      smart00036
      Location:1204 → 1500
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00233
      Location:1040 → 1159
      PH; Pleckstrin homology domain
      COG4942
      Location:679 → 961
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      PRK03918
      Location:2 → 641
      PRK03918; chromosome segregation protein; Provisional
      cd00029
      Location:959 → 1007
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00169
      Location:1040 → 1159
      PH; PH domain
      pfam00836
      Location:231 → 319
      Stathmin; Stathmin family
      pfam09311
      Location:462 → 743
      Rab5-bind; Rabaptin-like protein
      cl00788
      Location:188 → 253
      MttA_Hcf106; mttA/Hcf106 family

    12. XM_011537789.2 → XP_011536091.1  citron Rho-interacting kinase isoform X11

      See identical proteins and their annotated locations for XP_011536091.1

      UniProtKB/TrEMBL
      A0A7I2V692
      Related
      ENSP00000504849.1, ENST00000678652.1
      Conserved Domains (9) summary
      smart00036
      Location:1204 → 1500
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00233
      Location:1040 → 1159
      PH; Pleckstrin homology domain
      COG4942
      Location:679 → 961
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      PRK03918
      Location:2 → 641
      PRK03918; chromosome segregation protein; Provisional
      cd00029
      Location:959 → 1007
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00169
      Location:1040 → 1159
      PH; PH domain
      pfam00836
      Location:231 → 319
      Stathmin; Stathmin family
      pfam09311
      Location:462 → 743
      Rab5-bind; Rabaptin-like protein
      cl00788
      Location:188 → 253
      MttA_Hcf106; mttA/Hcf106 family

    13. XM_011537791.3 → XP_011536093.1  citron Rho-interacting kinase isoform X12

      UniProtKB/TrEMBL
      A0A7I2V692
      Conserved Domains (9) summary
      smart00036
      Location:1184 → 1480
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00233
      Location:1020 → 1139
      PH; Pleckstrin homology domain
      COG4942
      Location:659 → 941
      EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]
      PRK03918
      Location:12 → 578
      PRK03918; chromosome segregation protein; Provisional
      cd00029
      Location:939 → 987
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      pfam00169
      Location:1020 → 1139
      PH; PH domain
      pfam00836
      Location:211 → 299
      Stathmin; Stathmin family
      pfam09311
      Location:442 → 723
      Rab5-bind; Rabaptin-like protein
      cl00788
      Location:168 → 233
      MttA_Hcf106; mttA/Hcf106 family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      119673075..119864647 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370857.1 → XP_054226832.1  citron Rho-interacting kinase isoform X10

      UniProtKB/TrEMBL
      H7BYJ3

    2. XM_054370856.1 → XP_054226831.1  citron Rho-interacting kinase isoform X9

      UniProtKB/TrEMBL
      H7BYJ3

    3. XM_054370855.1 → XP_054226830.1  citron Rho-interacting kinase isoform X8

      UniProtKB/TrEMBL
      H7BYJ3

    4. XM_054370854.1 → XP_054226829.1  citron Rho-interacting kinase isoform X7

    5. XM_054370853.1 → XP_054226828.1  citron Rho-interacting kinase isoform X6

    6. XM_054370852.1 → XP_054226827.1  citron Rho-interacting kinase isoform X5

    7. XM_054370850.1 → XP_054226825.1  citron Rho-interacting kinase isoform X3

    8. XM_054370851.1 → XP_054226826.1  citron Rho-interacting kinase isoform X4

    9. XM_054370849.1 → XP_054226824.1  citron Rho-interacting kinase isoform X2

    10. XM_054370848.1 → XP_054226823.1  citron Rho-interacting kinase isoform X1

    11. XM_054370859.1 → XP_054226834.1  citron Rho-interacting kinase isoform X11

      UniProtKB/TrEMBL
      A0A7I2V692

    12. XM_054370858.1 → XP_054226833.1  citron Rho-interacting kinase isoform X11

      UniProtKB/TrEMBL
      A0A7I2V692

    13. XM_054370860.1 → XP_054226835.1  citron Rho-interacting kinase isoform X12

      UniProtKB/TrEMBL
      A0A7I2V692
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14578.2 GenPept UniProtKB/Swiss-Prot:O14578

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