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    epha4l eph receptor A4, like [ Danio rerio (zebrafish) ]

    Gene ID: 30687, updated on 4-Jan-2025

    Summary

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    Official Symbol
    epha4lprovided by ZNC
    Official Full Name
    eph receptor A4, likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990415-61
    See related
    Ensembl:ENSDARG00000010767 AllianceGenome:ZFIN:ZDB-GENE-990415-61
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rtk4
    Summary
    Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance and ephrin receptor signaling pathway. Predicted to act upstream of or within cell surface receptor protein tyrosine kinase signaling pathway and protein phosphorylation. Predicted to be located in early endosome and membrane. Predicted to be active in dendrite and plasma membrane. Is expressed in liver. Orthologous to human EPHA4 (EPH receptor A4). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See epha4l in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (41948096..42039192, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (41992404..42081853, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene si:ch211-191a16.2 Neighboring gene NACHT, LRR and PYD domains-containing protein 16 Neighboring gene si:dkey-96g2.1 Neighboring gene uncharacterized LOC110437941

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterisation of five novel zebrafish Eph-related receptor tyrosine kinases suggests roles in patterning the neural plate. Cooke JE, et al. Dev Genes Evol, 1997 May. PMID 27747378
    2. The construction of intrahepatic cholangiocarcinoma model in zebrafish. Wang J, et al. Sci Rep, 2017 Oct 17. PMID 29042681, Free PMC Article
    3. Zebrafish sox2 Is Required for the Swim Bladder Inflation by Controlling the Swim-Up Behavior. Cao S, et al. Zebrafish, 2023 Feb. PMID 36795618, Free PMC Article
    4. Eph receptors and ephrins: effectors of morphogenesis. Holder N, et al. Development, 1999 May. PMID 10207129
    5. foxl2 and foxl3 are two ancient paralogs that remain fully functional in teleosts. Crespo B, et al. Gen Comp Endocrinol, 2013 Dec 1. PMID 24045113

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane-ephrin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ephrin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eph receptor A4, like; ephrin type-A receptor 4
    Names
    eph-like receptor tyrosine kinase 4
    epha4c
    XP_687698.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      41948096..42039192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_682606.7 → XP_687698.2  ephrin type-A receptor 4

      UniProtKB/TrEMBL
      A0A8N7TAS1, F1QJD4
      Related
      ENSDARP00000003161.9, ENSDART00000004338.10
      Conserved Domains (7) summary
      cd09545
      Location:913 → 983
      SAM_EPH-A4; SAM domain of EPH-A4 subfamily of tyrosine kinase receptors
      smart00454
      Location:913 → 975
      SAM; Sterile alpha motif
      cd00063
      Location:442 → 533
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:616 → 882
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam07714
      Location:621 → 878
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:540 → 616
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
      cl02704
      Location:32 → 205
      EphR_LBD; Ligand Binding Domain of Ephrin Receptors
    Nucleotide Protein
    Heading Accession and Version

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