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    ANXA5 annexin A5 [ Gallus gallus (chicken) ]

    Gene ID: 428767, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ANXA5provided by CGNC
    Official Full Name
    annexin A5provided by CGNC
    Primary source
    CGNC:9009
    See related
    Ensembl:ENSGALG00010005260
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    ANX5; CBP-I; CPB-I; PAP-I
    Orthologs
    human mouse all
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    Genomic context

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    See ANXA5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (53469183..53512313)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (53471484..53515093)

    Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene cyclin A2 Neighboring gene exosome component 9 Neighboring gene uncharacterized LOC124417902 Neighboring gene pyroglutamylated RFamide peptide receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Key role of the N-terminus of chicken annexin A5 in vesicle aggregation. Turnay J, et al. Protein Sci, 2009 May. PMID 19388055, Free PMC Article
    2. Annexin V and terminal differentiation of growth plate chondrocytes. Wang W, et al. Exp Cell Res, 2005 Apr 15. PMID 15777796
    3. Isolation, characterization and localization of annexin V from chicken liver. Boustead CM, et al. Biochem J, 1993 Apr 15. PMID 8484740, Free PMC Article
    4. Structure of chicken annexin V at 2.25-A resolution. Bewley MC, et al. Biochemistry, 1993 Apr 20. PMID 8471604
    5. Structure of the gene encoding anchorin CII (chick annexin V). Fernández MP, et al. Gene, 1994 Apr 20. PMID 8163186

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study shows annexin A5 induces aggregation of vesicles containing acidic phospholipids even at low protein and/or calcium concentration by establishment of protein dimers; experiments show ability to aggregate vesicles mainly resides in the N-terminus
      Title: Key role of the N-terminus of chicken annexin A5 in vesicle aggregation.
    2. Overexpression of annexin V is sufficient to stimulate these terminal differentiation events in growth plate chondrocytes in the chick embryo.
      Title: Annexin V and terminal differentiation of growth plate chondrocytes.
    3. binding of annexin V to active PKCalpha stimulates apoptotic events in growth plate chondrocytes and binding of annexin V to beta5 integrin controls these interactions and ultimately apoptosis
      Title: Annexin V/beta5 integrin interactions regulate apoptosis of growth plate chondrocytes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium-dependent phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of coagulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    annexin A5
    Names
    VAC-alpha
    anchorin CII
    annexin V
    annexin-5
    calphobindin I
    endonexin II
    lipocortin V
    placental anticoagulant protein I
    thromboplastin inhibitor
    vascular anticoagulant-alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031538.2 → NP_001026709.1  annexin A5

      See identical proteins and their annotated locations for NP_001026709.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000074
      UniProtKB/Swiss-Prot
      P17153
      UniProtKB/TrEMBL
      A0A8V0XMH5
      Conserved Domains (1) summary
      pfam00191
      Location:250 → 315
      Annexin

    2. NM_001397309.1 → NP_001384238.1  annexin A5

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000074
      UniProtKB/Swiss-Prot
      P17153
      UniProtKB/TrEMBL
      A0A8V0XMH5
      Conserved Domains (1) summary
      pfam00191
      Location:250 → 315
      Annexin

    3. NM_001397310.1 → NP_001384239.1  annexin A5

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000074
      UniProtKB/Swiss-Prot
      P17153
      UniProtKB/TrEMBL
      A0A8V0XMH5
      Conserved Domains (1) summary
      pfam00191
      Location:250 → 315
      Annexin

    4. NM_001397311.1 → NP_001384240.1  annexin A5

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000074
      UniProtKB/Swiss-Prot
      P17153
      UniProtKB/TrEMBL
      A0A8V0XMH5
      Conserved Domains (1) summary
      pfam00191
      Location:250 → 315
      Annexin

    5. NM_001397312.1 → NP_001384241.1  annexin A5

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000074
      UniProtKB/Swiss-Prot
      P17153
      UniProtKB/TrEMBL
      A0A8V0XMH5
      Conserved Domains (1) summary
      pfam00191
      Location:250 → 315
      Annexin

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      53469183..53512313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046940311.1 → XP_046796267.1  annexin A5 isoform X1

      UniProtKB/Swiss-Prot
      P17153
      UniProtKB/TrEMBL
      A0A8V0XMH5
      Related
      ENSGALP00010007026.1, ENSGALT00010012462.1

    2. XM_046940312.1 → XP_046796268.1  annexin A5 isoform X1

      UniProtKB/Swiss-Prot
      P17153
      UniProtKB/TrEMBL
      A0A8V0XMH5

    3. XM_046940313.1 → XP_046796269.1  annexin A5 isoform X1

      UniProtKB/Swiss-Prot
      P17153
      UniProtKB/TrEMBL
      A0A8V0XMH5
      Related
      ENSGALP00010007025.1, ENSGALT00010012461.1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      53471484..53515093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046916524.1 → XP_046772480.1  annexin A5 isoform X1

      UniProtKB/Swiss-Prot
      P17153
      UniProtKB/TrEMBL
      A0A8V0XMH5

    2. XM_046916525.1 → XP_046772481.1  annexin A5 isoform X1

      UniProtKB/Swiss-Prot
      P17153
      UniProtKB/TrEMBL
      A0A8V0XMH5

    3. XM_046916526.1 → XP_046772482.1  annexin A5 isoform X1

      UniProtKB/Swiss-Prot
      P17153
      UniProtKB/TrEMBL
      A0A8V0XMH5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17153.2 GenPept UniProtKB/Swiss-Prot:P17153

    Gene LinkOut

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