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    ATP2B1 ATPase plasma membrane Ca2+ transporting 1 [ Sus scrofa (pig) ]

    Gene ID: 397636, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ATP2B1provided by VGNC
    Official Full Name
    ATPase plasma membrane Ca2+ transporting 1provided by VGNC
    Primary source
    VGNC:VGNC:103219
    See related
    Ensembl:ENSSSCG00000027898
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Expression
    Ubiquitous expression in lung (RPKM 20.1), spleen (RPKM 13.1) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See ATP2B1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 5 NC_010447.5 (92935688..93061406)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 5 NC_010447.4 (97597062..97709794)

    Chromosome 5 - NC_010447.5Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110260799 Neighboring gene uncharacterized LOC106507542 Neighboring gene collagen alpha-1(I) chain Neighboring gene uncharacterized LOC106510436 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 4 Neighboring gene POC1 centriolar protein B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. Lysophosphatidic acid (LPA) as a modulator of plasma membrane Ca(2+)-ATPase from basolateral membranes of kidney proximal tubules. Sant'Anna JF, et al. J Physiol Biochem, 2021 May. PMID 33704695
    2. The plasma membrane Ca2+ pump catalyzes the hydrolysis of ATP at low rate in the absence of Ca2+. Mazzitelli LR, et al. Arch Biochem Biophys, 2010 Mar 1. PMID 20035709
    3. The interaction of ethanol with reconstituted synaptosomal plasma membrane Ca2+ -ATPase. Sepúlveda MR, et al. Biochim Biophys Acta, 2004 Oct 11. PMID 15471573
    4. Molecular cloning and sequencing of the plasma-membrane Ca2+ pump of pig smooth muscle. De Jaegere S, et al. Biochem J, 1990 Nov 1. PMID 2147100, Free PMC Article
    5. Ceramide is a potent activator of plasma membrane Ca2+-ATPase from kidney-promixal tubule cells with protein kinase A as an intermediate. Cabral LM, et al. J Biol Chem, 2007 Aug 24. PMID 17606608

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lysophosphatidic acid (LPA) as a modulator of plasma membrane Ca(2+)-ATPase from basolateral membranes of kidney proximal tubules.
      Title: Lysophosphatidic acid (LPA) as a modulator of plasma membrane Ca(2+)-ATPase from basolateral membranes of kidney proximal tubules.
    2. Purified plasma membrane Ca2+ ATPase was able to hydrolyze ATP at a very low rate in the absence of Ca2+.
      Title: The plasma membrane Ca2+ pump catalyzes the hydrolysis of ATP at low rate in the absence of Ca2+.
    3. ceramide activates plasma membrane Ca2+-ATPase from kidney-promixal tubule cells with protein kinase A as an intermediate
      Title: Ceramide is a potent activator of plasma membrane Ca2+-ATPase from kidney-promixal tubule cells with protein kinase A as an intermediate.
    4. results suggest that the activating mechanism of ethanol may involve opening an autoinhibitory domain located close to the calmodulin binding domain
      Title: The interaction of ethanol with reconstituted synaptosomal plasma membrane Ca2+ -ATPase.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables PDZ domain binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plasma membrane calcium-transporting ATPase 1
    Names
    PMCA1
    plasma membrane Ca2+ pump (PMCA1b)
    plasma membrane calcium ATPase
    plasma membrane calcium pump
    NP_999517.1
    XP_020946834.1
    XP_020946835.1
    XP_020946836.1
    XP_020946837.1
    XP_020946839.1
    XP_020946840.1
    XP_020946841.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214352.3 → NP_999517.1  plasma membrane calcium-transporting ATPase 1

      See identical proteins and their annotated locations for NP_999517.1

      Status: PROVISIONAL

      Source sequence(s)
      X53456
      UniProtKB/Swiss-Prot
      P23220
      UniProtKB/TrEMBL
      A0A286ZTB3
      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 1064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1103 → 1149
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010447.5 Reference Sscrofa11.1 Primary Assembly

      Range
      92935688..93061406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021091178.1 → XP_020946837.1  plasma membrane calcium-transporting ATPase 1 isoform X3

      UniProtKB/TrEMBL
      A0A0B8S0B7, A0A286ZTB3, A0A4X1SFH3, A0A8D2CCF9, F1SPZ4
      Related
      ENSSSCP00000000984.3, ENSSSCT00000001006.4
      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 1064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1103 → 1149
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    2. XM_021091176.1 → XP_020946835.1  plasma membrane calcium-transporting ATPase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8D0M647, A0A8D0YIR6
      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 1064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1103 → 1187
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    3. XM_021091175.1 → XP_020946834.1  plasma membrane calcium-transporting ATPase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8D0M647, A0A8D0YIR6
      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 1064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1103 → 1187
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    4. XM_021091182.1 → XP_020946841.1  plasma membrane calcium-transporting ATPase 1 isoform X5

      UniProtKB/TrEMBL
      A0A8D0SY54, A0A8D0XHQ4
      Conserved Domains (2) summary
      pfam12424
      Location:1103 → 1142
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:15 → 1064
      E1-E2_ATPase; E1-E2 ATPase

    5. XM_021091177.1 → XP_020946836.1  plasma membrane calcium-transporting ATPase 1 isoform X2

      UniProtKB/TrEMBL
      A0A5G2R8B2, A0A8D0M647, A0A8D0T7R2, A0A8X9AEX2
      Related
      ENSSSCP00000066847.2, ENSSSCT00000069086.2
      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 1064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1103 → 1178
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    6. XM_021091180.1 → XP_020946839.1  plasma membrane calcium-transporting ATPase 1 isoform X3

      UniProtKB/TrEMBL
      A0A0B8S0B7, A0A286ZTB3, A0A4X1SFH3, A0A8D2CCF9, F1SPZ4
      Conserved Domains (2) summary
      TIGR01517
      Location:15 → 1064
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam12424
      Location:1103 → 1149
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

    7. XM_021091181.1 → XP_020946840.1  plasma membrane calcium-transporting ATPase 1 isoform X4

      UniProtKB/TrEMBL
      A0A480T6H1, A0A4X1SFM1, A0A8D0PP48, A0A8D0XHQ4
      Conserved Domains (2) summary
      pfam12424
      Location:1103 → 1142
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      cl27747
      Location:15 → 1064
      E1-E2_ATPase; E1-E2 ATPase

    RNA

    1. XR_002343820.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23220.1 GenPept UniProtKB/Swiss-Prot:P23220

    Gene LinkOut

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