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    fen1.S flap structure-specific endonuclease 1 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 394311, updated on 4-Jan-2025

    Summary

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    Official Symbol
    fen1.S
    Official Full Name
    flap structure-specific endonuclease 1 S homeolog
    Primary source
    Xenbase:XB-GENE-6254462
    Locus tag
    XELAEV_18024332mg
    See related
    EnsemblRapid:ENSXLAG00005005572 AllianceGenome:Xenbase:XB-GENE-6254462
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    mf1; fen1; rad2; fen-1; fen1-a; fen1-b
    Summary
    Enables 5'-flap endonuclease activity. Acts upstream of or within DNA replication. Located in nucleus. Orthologous to human FEN1 (flap structure-specific endonuclease 1). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See fen1.S in Genome Data Viewer
    Location:
    chromosome: 4S
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4S NC_054378.1 (6737554..6740695)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4S NC_030731.1 (6569035..6572175)

    Chromosome 4S - NC_054378.1Genomic Context describing neighboring genes Neighboring gene diacylglycerol lipase, alpha S homeolog Neighboring gene myelin regulatory factor S homeolog Neighboring gene fatty acid desaturase 1 S homeolog Neighboring gene fatty acid desaturase 2 S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of FEN-1 from Xenopus laevis. cDNA cloning and role in DNA metabolism. Bibikova M, et al. J Biol Chem, 1998 Dec 18. PMID 9852084
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables 5'-3' exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5'-flap endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-flap endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA replication, removal of RNA primer IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within base-excision repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within base-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    flap endonuclease 1-B
    Names
    flap endonuclease 1
    xFEN-1b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001087515.1 → NP_001080984.1  flap endonuclease 1-B

      See identical proteins and their annotated locations for NP_001080984.1

      Status: PROVISIONAL

      Source sequence(s)
      U68141
      UniProtKB/Swiss-Prot
      B7ZPB1, P70054
      UniProtKB/TrEMBL
      A0A974D016
      Related
      ENSXLAP00005016442.1, ENSXLAT00005016738.1
      Conserved Domains (3) summary
      cd09907
      Location:221 → 290
      H3TH_FEN1-Euk; H3TH domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease: Eukaryotic homologs
      cd09867
      Location:4 → 344
      PIN_FEN1; PIN domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
      PTZ00217
      Location:1 → 359
      PTZ00217; flap endonuclease-1; Provisional

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054378.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      6737554..6740695
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70054.1 GenPept UniProtKB/Swiss-Prot:P70054

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.