meis3 myeloid ecotropic viral integration site 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: meis3provided by ZNC
Official Full Name: myeloid ecotropic viral integration site 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-010406-2
See related: Ensembl:ENSDARG00000002795 AllianceGenome:ZFIN:ZDB-GENE-010406-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: NH10; fc22g05; meis3.1; id:ibd3530; wu:fc22g05
Summary: Enables sequence-specific DNA binding activity. Involved in hindbrain development and positive regulation of transcription by RNA polymerase II. Acts upstream of or within enteric nervous system development; exocrine pancreas development; and neural crest cell migration involved in autonomic nervous system development. Located in cytoplasm and nucleus. Is expressed in several structures, including fin bud; mesoderm; neural keel; neural plate; and posterior neural tube. Orthologous to several human genes including MEIS3 (Meis homeobox 3) and MEIS3P2 (Meis homeobox 3 pseudogene 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (6838071..6863317, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (6840537..6866348, complement)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Meis3 and pbx4 regulate shh expression in anterior endoderm, thereby influencing patterning and growth of the foregut.
Title: TALE-family homeodomain proteins regulate endodermal sonic hedgehog expression and pattern the anterior endoderm.

Submit: New GeneRIF Correction

General gene information

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Markers

fc22g05.x1 (e-PCR)
- UniSTS:203886

fb82a09.y1 (e-PCR)
- UniSTS:191666

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in embryonic pattern specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within enteric nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye development	IBA Inferred from Biological aspect of Ancestor more info
involved_in hemopoiesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in hindbrain development	IGI Inferred from Genetic Interaction more info
acts_upstream_of_or_within neural crest cell migration involved in autonomic nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein Meis3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.