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    mcm4.S minichromosome maintenance complex component 4 S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 373601, updated on 4-Jan-2025

    Summary

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    Official Symbol
    mcm4.S
    Official Full Name
    minichromosome maintenance complex component 4 S homeolog
    Primary source
    Xenbase:XB-GENE-6252896
    Locus tag
    XELAEV_18033701mg
    See related
    EnsemblRapid:ENSXLAG00005032702 AllianceGenome:Xenbase:XB-GENE-6252896
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    mcm4; cdc21; mcm4-a; mcm4-b; mcm4.L
    Summary
    Contributes to chromatin binding activity. Acts upstream of or within regulation of DNA-templated DNA replication initiation. Located in chromatin. Part of CMG complex and MCM complex. Human ortholog(s) of this gene implicated in immunodeficiency 54. Orthologous to human MCM4 (minichromosome maintenance complex component 4). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See mcm4.S in Genome Data Viewer
    Location:
    chromosome: 6S
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 6S NC_054382.1 (98869629..98886594)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 6S NC_030735.1 (90186691..90203800)

    Chromosome 6S - NC_054382.1Genomic Context describing neighboring genes Neighboring gene microtubule associated protein RP/EB family member 2 S homeolog Neighboring gene CCAAT enhancer binding protein delta S homeolog Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene ubiquitin conjugating enzyme E2 V2 S homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cdc7-Drf1 is a developmentally regulated protein kinase required for the initiation of vertebrate DNA replication. Takahashi TS, et al. Genes Dev, 2005 Oct 1. PMID 16204181, Free PMC Article
    2. Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses. Yoo HY, et al. J Biol Chem, 2004 Dec 17. PMID 15448142
    3. The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides. Thömmes P, et al. EMBO J, 1997 Jun 2. PMID 9214646, Free PMC Article
    4. Licensing of DNA replication by a multi-protein complex of MCM/P1 proteins in Xenopus eggs. Kubota Y, et al. EMBO J, 1997 Jun 2. PMID 9214647, Free PMC Article
    5. Mitotic replisome disassembly depends on TRAIP ubiquitin ligase activity. Priego Moreno S, et al. Life Sci Alliance, 2019 Apr. PMID 30979826, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC98251

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to single-stranded DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA unwinding involved in DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CMG complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MCM complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of MCM complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA replication licensing factor mcm4-A
    Names
    CDC21 homolog-A
    P1-CDC21-A
    S.pombe cdc21+ homologue
    minichromosome maintenance complex component 4 L homeolog
    minichromosome maintenance deficient 4
    minichromosome maintenance protein 4-A
    p98
    xMCM4-A
    NP_001079069.1
    XP_018124038.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085600.2 → NP_001079069.1  DNA replication licensing factor mcm4-A

      See identical proteins and their annotated locations for NP_001079069.1

      Status: PROVISIONAL

      Source sequence(s)
      U44049
      UniProtKB/Swiss-Prot
      O42589, Q5XK83
      Related
      ENSXLAP00005098349.1, ENSXLAT00005100161.1
      Conserved Domains (3) summary
      smart00350
      Location:262 → 765
      MCM; minichromosome maintenance proteins
      pfam14551
      Location:160 → 282
      MCM_N; MCM N-terminal domain
      cl21455
      Location:500 → 639
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054382.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      98869629..98886594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_018268549.2 → XP_018124038.1  DNA replication licensing factor mcm4-A isoform X1

      UniProtKB/Swiss-Prot
      O42589, Q5XK83
      UniProtKB/TrEMBL
      A0A1L8FSY2, A0A974CJQ6
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XK83.1 GenPept UniProtKB/Swiss-Prot:Q5XK83

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials