plk1.S polo like kinase 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: plk1.S
Official Full Name: polo like kinase 1 S homeolog
Primary source: Xenbase:XB-GENE-941545
Locus tag: XELAEV_18047692mg
See related: EnsemblRapid:ENSXLAG00005008342 AllianceGenome:Xenbase:XB-GENE-941545
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: plk; plk1
Summary: Enables protein kinase binding activity and protein serine/threonine kinase activity. Acts upstream of or within oocyte maturation. Predicted to be located in several cellular components, including kinetochore; microtubule cytoskeleton; and midbody. Human ortholog(s) of this gene implicated in urinary bladder cancer. Orthologous to human PLK1 (polo like kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

Location:: chromosome: 9_10S

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10S	NC_054388.1 (100466768..100475872)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10S	NC_030741.1 (93840215..93849322)

Chromosome 9_10S - NC_054388.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Polo-like kinase 1 (Plk1) regulates DNA replication origin firing and interacts with Rif1 in Xenopus.
Title: Polo-like kinase 1 (Plk1) regulates DNA replication origin firing and interacts with Rif1 in Xenopus.
Polo-like kinase 1 (Plk1) is a positive regulator of DNA replication in the Xenopus in vitro system.
Title: Polo-like kinase 1 (Plk1) is a positive regulator of DNA replication in the Xenopus in vitro system.
Novel roles for Plk and GSK3 regulation of ADAM13 function in cranial neural crest cell migration.
Title: GSK3 and Polo-like kinase regulate ADAM13 function during cranial neural crest cell migration.
Plx1-mediated degradation of Bora in interphase generates oscillations in Plx1 activity and is essential for development.
Title: Phosphorylation-mediated stabilization of Bora in mitosis coordinates Plx1/Plk1 and Cdk1 oscillations.
Coordinated interplays between Plx1 and Gwl are required for reactivation of these kinases from the G(2)/M DNA damage checkpoint and efficient checkpoint recovery.
Title: Greatwall and Polo-like kinase 1 coordinate to promote checkpoint recovery.
Plx1 promotes activation of Aurora A, most likely through TPX2.
Title: Phosphorylation of TPX2 by Plx1 enhances activation of Aurora A.
Cdk1 phosphorylation of BubR1 controls spindle checkpoint arrest and plk-mediated formation of the 3F3/2 epitope.
Title: Cdk1 phosphorylation of BubR1 controls spindle checkpoint arrest and Plk1-mediated formation of the 3F3/2 epitope.
Data show that Plx1 couples tension signals to cellular responses through phosphorylation of the 3F3/2 epitope and targeting structural and checkpoint proteins to kinetochores.
Title: Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores.
Results suggest that polo-like kinase (Plx1) could be the missing regulator that prevents maturation-promoting factor autoamplification in stage IV oocytes.
Title: Polo-like kinase confers MPF autoamplification competence to growing Xenopus oocytes.
Plx1 cooperates with CaMKII to regulate cyclosome regulators, and is necessary for release of cytostatic factor metaphase arrest and sufficient when overexpressed.
Title: Calcium elevation at fertilization coordinates phosphorylation of XErp1/Emi2 by Plx1 and CaMK II to release metaphase arrest by cytostatic factor.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G2/M transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within G2/M transition of mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within centrosome cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within microtubule bundle formation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitotic G2 DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitotic cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within oocyte maturation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein localization to chromatin	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle midzone	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine/threonine-protein kinase PLK1

Names: PLK-1; plx1; polo-like kinase 1

NP_001080788.1

EC 2.7.11.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087319.1 → NP_001080788.1 serine/threonine-protein kinase PLK1

See identical proteins and their annotated locations for NP_001080788.1

Status: PROVISIONAL

Source sequence(s)

U58205

UniProtKB/Swiss-Prot

P70032, Q7ZWQ6

UniProtKB/TrEMBL

A0A974BVC0

Related

ENSXLAP00005024019.1, ENSXLAT00005024727.1

Conserved Domains (4) summary

smart00220
Location:49 → 296

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13117
Location:503 → 584

POLO_box_2; Second polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd13118
Location:401 → 488

POLO_box_1; First polo-box domain (PBD) of polo-like kinases Plk1, Plk2, Plk3, and Plk5

cd14187
Location:36 → 300

STKc_PLK1; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1