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    LOC100135793 matrix metalloproteinase-2 [ Oncorhynchus mykiss (rainbow trout) ]

    Gene ID: 100135793, updated on 14-Dec-2023

    Summary

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    Gene symbol
    LOC100135793
    Gene description
    matrix metalloproteinase-2
    See related
    Ensembl:ENSOMYG00000020411
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Oncorhynchus mykiss
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes; Salmonidae; Salmoninae; Oncorhynchus
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    Genomic context

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    See LOC100135793 in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    101 current USDA_OmykA_1.1 (GCF_013265735.2) 26 NC_048590.1 (38058526..38085611)
    100 previous assembly Omyk_1.0 (GCF_002163495.1) 26 NC_035102.1 (27804912..27830805)

    Chromosome 26 - NC_048590.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC118944515 Neighboring gene iroquois-class homeodomain protein IRX-6-like Neighboring gene uncharacterized LOC110506749 Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene sodium-dependent noradrenaline transporter

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in collagen catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in tissue remodeling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    matrix metalloproteinase-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001124189.1 → NP_001117661.1  matrix metalloproteinase-2 precursor

      See identical proteins and their annotated locations for NP_001117661.1

      Status: PROVISIONAL

      Source sequence(s)
      AB021698
      UniProtKB/TrEMBL
      A0A8C7VTE2, Q9W635
      Related
      ENSOMYP00000045763.2, ENSOMYT00000049810.2
      Conserved Domains (5) summary
      smart00059
      Location:281 → 329
      FN2; Fibronectin type 2 domain
      cd00094
      Location:460 → 654
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:115 → 443
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:115 → 443
      Peptidase_M10; Matrixin
      pfam01471
      Location:67 → 94
      PG_binding_1; Putative peptidoglycan binding domain

    RefSeqs of Annotated Genomes: Oncorhynchus mykiss Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference USDA_OmykA_1.1 Primary Assembly

    Genomic

    1. NC_048590.1 Reference USDA_OmykA_1.1 Primary Assembly

      Range
      38058526..38085611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036963145.1 → XP_036819040.1  matrix metalloproteinase-2 isoform X1

      UniProtKB/TrEMBL
      A0A8C7VTE2
      Conserved Domains (4) summary
      smart00059
      Location:339 → 387
      FN2; Fibronectin type 2 domain
      cd00094
      Location:460 → 654
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:115 → 443
      Peptidase_M10; Matrixin
      pfam01471
      Location:67 → 94
      PG_binding_1; Putative peptidoglycan binding domain
    Nucleotide Protein
    Heading Accession and Version

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