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    PDE6A phosphodiesterase 6A [ Canis lupus familiaris (dog) ]

    Gene ID: 403620, updated on 17-Aug-2024

    Summary

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    Official Symbol
    PDE6Aprovided by VGNC
    Official Full Name
    phosphodiesterase 6Aprovided by VGNC
    Primary source
    VGNC:VGNC:44357
    See related
    Ensembl:ENSCAFG00845008935
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    PDEA
    Orthologs
    human mouse all
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    Genomic context

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    See PDE6A in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 4 NC_051808.1 (59584148..59644927)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 4 NC_006586.4 (58869721..58929621)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 4 NC_049225.1 (60018959..60078866)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 4 NC_049264.1 (59373301..59433215)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 4 NC_049745.1 (59487640..59547674)

    Chromosome 4 - NC_051808.1Genomic Context describing neighboring genes Neighboring gene tigger transposable element derived 6 Neighboring gene solute carrier family 26 member 2 Neighboring gene PPARG coactivator 1 beta Neighboring gene U6 spliceosomal RNA Neighboring gene microRNA mir-378

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a canine model of autosomal recessive retinitis pigmentosa due to a PDE6A mutation. Tuntivanich N, et al. Invest Ophthalmol Vis Sci, 2009 Feb. PMID 18775863, Free PMC Article
    2. Exclusion of the PDE6A gene for generalised progressive retinal atrophy in 11 breeds of dog. Dekomien G, et al. Anim Genet, 2000 Apr. PMID 10782214
    3. cGMP phosphodiesterase-alpha mutation causes progressive retinal atrophy in the Cardigan Welsh corgi dog. Petersen-Jones SM, et al. Invest Ophthalmol Vis Sci, 1999 Jul. PMID 10393029
    4. Microsatellite (CA)n polymorphism in intron 2 of the canine rod photoreceptor cGMP-phosphodiesterase alpha-subunit gene. Veske A, et al. Anim Genet, 1997 Oct. PMID 9363616
    5. Cloning and characterization of the cDNA encoding the alpha-subunit of cGMP-phosphodiesterase in canine retinal rod photoreceptor cells. Wang W, et al. Mol Vis, 1996 May 9. PMID 9233984

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha
    Names
    GMP-PDE alpha
    cGMP-phosphodiesterase alpha-subunit
    rod specific cGMP phosphodiesterase, alpha subunit
    NP_001003073.1
    XP_038518137.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003073.1 → NP_001003073.1  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha

      See identical proteins and their annotated locations for NP_001003073.1

      Status: PROVISIONAL

      Source sequence(s)
      U52868
      UniProtKB/TrEMBL
      A0A8C0M8N3
      Related
      ENSCAFP00845012309.1, ENSCAFT00845015823.1
      Conserved Domains (2) summary
      smart00065
      Location:254 → 441
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:558 → 802
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051808.1 Reference ROS_Cfam_1.0

      Range
      59584148..59644927
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038662209.1 → XP_038518137.1  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1

      UniProtKB/TrEMBL
      A0A8C0M8N3
      Conserved Domains (2) summary
      smart00065
      Location:274 → 461
      GAF; Domain present in phytochromes and cGMP-specific phosphodiesterases
      pfam00233
      Location:578 → 822
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049264.1 Alternate UMICH_Zoey_3.1

      Range
      59373301..59433215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049745.1 Alternate UNSW_CanFamBas_1.0

      Range
      59487640..59547674
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049225.1 Alternate UU_Cfam_GSD_1.0

      Range
      60018959..60078866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006586.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      58869721..58929621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q28263.2 GenPept UniProtKB/Swiss-Prot:Q28263

    Gene LinkOut

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