EIF5AL1 eukaryotic translation initiation factor 5A like 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: EIF5AL1provided by HGNC
Official Full Name: eukaryotic translation initiation factor 5A like 1provided by HGNC
Primary source: HGNC:HGNC:17419
See related: Ensembl:ENSG00000253626 AllianceGenome:HGNC:17419
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EIF5A; eIF-4D; eIF-5A; EIF5AP1; eIF-5A1; eIF-5A-1; bA342M3.3
Summary: Predicted to enable translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to be located in endoplasmic reticulum membrane and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 10q22.3

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (79512533..79516440)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (80381663..80385570)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (81272289..81276196)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Comparison of Human Eukaryotic Translation Initiation Factors 5A1 and 5AL1: Identification of Amino Acid Residues Important for EIF5A1 Lysine 50 Hypusination and Its Protein Stability.
Title: Comparison of Human Eukaryotic Translation Initiation Factors 5A1 and 5AL1: Identification of Amino Acid Residues Important for EIF5A1 Lysine 50 Hypusination and Its Protein Stability.
EIF5AL1 expression is associated with colorectal cancer metastasis.
Title: Integrative analysis of significant RNA-binding proteins in colorectal cancer metastasis.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10S680 (e-PCR)
- UniSTS:148748

RH67341 (e-PCR)
- UniSTS:88764

RH93153 (e-PCR)
- UniSTS:85950

RH39404 (e-PCR)
- UniSTS:86005

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of translational elongation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translational termination	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 5A-1-like

Names: Eukaryotic translation initiation factor 5A-1; Rev-binding factor; eukaryotic translation initiation factor 5A pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001099692.2 → NP_001093162.1 eukaryotic translation initiation factor 5A-1-like

See identical proteins and their annotated locations for NP_001093162.1

Status: VALIDATED

Source sequence(s)

AL133481

Consensus CDS

CCDS53546.1

UniProtKB/Swiss-Prot

Q6IS14

UniProtKB/TrEMBL

I3L397

Related

ENSP00000430706.2, ENST00000520547.4

Conserved Domains (2) summary

PLN03107
Location:1 → 150

PLN03107; eukaryotic translation initiation factor 5A; Provisional

cd04468
Location:84 → 152

S1_eIF5A; S1_eIF5A: Eukaryotic translation Initiation Factor 5A (eIF5A), S1-like RNA-binding domain. eIF5A is an evolutionarily conserved protein found in eukaryotes. eIF5A is the only protein known to have the unusual amino acid hypusine. Hypusine is essential ...