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    Psmb5 proteasome 20S subunit beta 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29425, updated on 27-Nov-2024

    Summary

    Official Symbol
    Psmb5provided by RGD
    Official Full Name
    proteasome 20S subunit beta 5provided by RGD
    Primary source
    RGD:61879
    See related
    EnsemblRapid:ENSRNOG00000013386 AllianceGenome:RGD:61879
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable endopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within proteolysis and response to oxidative stress. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Orthologous to human PSMB5 (proteasome 20S subunit beta 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 533.6), Heart (RPKM 450.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Psmb5 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32042784..32047379, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28072772..28077367, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33259039..33263634, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ajuba LIM protein Neighboring gene similar to human chromosome 14 open reading frame 93 Neighboring gene transfer RNA alanine (anticodon AGC) 93 Neighboring gene proteasome subunit beta 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables threonine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of proteasome core complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome core complex, beta-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    proteasome subunit beta type-5
    Names
    beta-5
    macropain epsilon chain
    multicatalytic endopeptidase complex epsilon chain
    proteasome (prosome, macropain) subunit, beta type 5
    proteasome beta 5 subunit
    proteasome beta type subunit 5
    proteasome chain 6
    proteasome epsilon chain
    proteasome subunit X
    proteasome subunit beta 5
    NP_001099197.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105727.2NP_001099197.2  proteasome subunit beta type-5

      See identical proteins and their annotated locations for NP_001099197.2

      Status: VALIDATED

      Source sequence(s)
      AI602737, CB783917
      UniProtKB/Swiss-Prot
      P28075
      UniProtKB/TrEMBL
      G3V7Q6
      Related
      ENSRNOP00000018005.4, ENSRNOT00000018005.9
      Conserved Domains (2) summary
      PTZ00488
      Location:29263
      PTZ00488; Proteasome subunit beta type-5; Provisional
      cd03761
      Location:60247
      proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32042784..32047379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)