Slc25a25 solute carrier family 25 member 25 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc25a25provided by RGD
Official Full Name: solute carrier family 25 member 25provided by RGD
Primary source: RGD:628666
See related: EnsemblRapid:ENSRNOG00000014338 AllianceGenome:RGD:628666
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mcsc; Pcscl; SCaMC-2
Summary: Predicted to enable ATP:phosphate antiporter activity. Predicted to be involved in ADP transport and ATP transport. Predicted to act upstream of or within several processes, including response to activity; response to dietary excess; and response to food. Located in mitochondrion. Orthologous to human SLC25A25 (solute carrier family 25 member 25). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 188.9), Brain (RPKM 91.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (36106448..36139812, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (15708702..15742195, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (11442396..11476186, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a biophysical model of the APC
Title: A biophysical model of the mitochondrial ATP-Mg/P(i) carrier.
may play an important role in regulating the function of hepatocytes rather than in differentiation in vivo
Title: A novel mitochondrial Ca2+-dependent solute carrier in the liver identified by mRNA differential display.
ATP magnesium phosphate carrier, by regulating the matrix adenine nucleotide content, can modulate the sensitivity of rat liver mitochondria to undergo permeability transition
Title: Permeability transition in rat liver mitochondria is modulated by the ATP-Mg/Pi carrier.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:547045

Slc25a25 (e-PCR), detects polymorphism
- UniSTS:547045

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP:phosphate antiporter activity	IEA Inferred from Electronic Annotation more info
enables ATP:phosphate antiporter activity	ISO Inferred from Sequence Orthology more info
enables ATP:phosphate antiporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ADP transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ATP transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in ATP transport	IEA Inferred from Electronic Annotation more info
involved_in adipose tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in camera-type eye development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in cellular respiration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular respiration	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in response to activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to activity	ISO Inferred from Sequence Orthology more info
involved_in response to dietary excess	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to dietary excess	ISO Inferred from Sequence Orthology more info
involved_in response to food	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to food	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial adenyl nucleotide antiporter SLC25A25

Names: ATP-Mg/Pi carrier; calcium-binding mitochondrial carrier protein SCaMC-2; mitochondrial ATP-Mg/Pi carrier protein; mitochondrial Ca2+-dependent solute carrier; mitochondrial calcium-dependent solute carrier; peroxisomal Ca(2+)-dependent solute carrier-like protein; peroxisomal Ca-dependent solute carrier-like protein; short calcium-binding mitochondrial carrier protein 2; small calcium-binding mitochondrial carrier protein 2; solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431501.1 → NP_001418430.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6AHU5, A0A8I6ALC5, A6JU64
NM_001431502.1 → NP_001418431.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6AHU5
NM_001431503.1 → NP_001418432.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6AFK8, A0A8I6AHU5
NM_001431504.1 → NP_001418433.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6AHU5, A0A8I6GFE3
NM_001431505.1 → NP_001418434.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6AHU5, A0A8L2QB89
NM_001431506.1 → NP_001418435.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 7

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6AHU5
NM_001431507.1 → NP_001418436.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 8

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003
NM_001431508.1 → NP_001418437.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 9

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6AHU5
NM_001431509.1 → NP_001418438.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 10

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6AHU5
NM_145677.2 → NP_663710.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform 6

See identical proteins and their annotated locations for NP_663710.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q8K3P6

UniProtKB/TrEMBL

A0A8I6AHU5, A6JU65

Conserved Domains (4) summary

cd00051
Location:82 → 141

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00153
Location:276 → 368

Mito_carr; Mitochondrial carrier protein

pfam13499
Location:83 → 138

EF-hand_7; EF-hand domain pair

cl08302
Location:29 → 77

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

36106448..36139812 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233932.5 → XP_006233994.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform X2

Related

ENSRNOP00000093449.1, ENSRNOT00000107630.2

Conserved Domains (2) summary

PTZ00184
Location:53 → 172

PTZ00184; calmodulin; Provisional

PTZ00169
Location:224 → 478

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
XM_006233931.4 → XP_006233993.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform X1

Related

ENSRNOP00000087701.2, ENSRNOT00000115249.2

Conserved Domains (3) summary

PTZ00169
Location:236 → 490

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

cl28895
Location:115 → 204

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

cl25352
Location:46 → 158

EFh_PEF; The penta-EF hand (PEF) family
XM_017591471.3 → XP_017446960.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform X8

Related

ENSRNOP00000092658.2, ENSRNOT00000102915.2
XM_006233934.5 → XP_006233996.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform X4

Conserved Domains (2) summary

PTZ00169
Location:211 → 465

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

cl25352
Location:73 → 159

EFh_PEF; The penta-EF hand (PEF) family
XM_006233933.5 → XP_006233995.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform X3

Related

ENSRNOP00000091438.1, ENSRNOT00000104155.2

Conserved Domains (3) summary

PTZ00169
Location:223 → 477

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

cl28895
Location:102 → 191

EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

cl25352
Location:73 → 145

EFh_PEF; The penta-EF hand (PEF) family
XM_063283100.1 → XP_063139170.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform X6

UniProtKB/TrEMBL

A0A8I6AEC3, A0A8I6AHU5

Related

ENSRNOP00000092861.2, ENSRNOT00000099400.2
XM_063283101.1 → XP_063139171.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform X7
XM_006233935.5 → XP_006233997.1 mitochondrial adenyl nucleotide antiporter SLC25A25 isoform X5

Related

ENSRNOP00000020206.5, ENSRNOT00000020206.7

Conserved Domains (4) summary

cd00051
Location:82 → 153

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

pfam00153
Location:288 → 380

Mito_carr; Mitochondrial carrier protein

pfam13499
Location:83 → 150

EF-hand_7; EF-hand domain pair

cl08302
Location:29 → 77

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...