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    Ciao2b cytosolic iron-sulfur assembly component 2B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680987, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ciao2bprovided by RGD
    Official Full Name
    cytosolic iron-sulfur assembly component 2Bprovided by RGD
    Primary source
    RGD:1585802
    See related
    EnsemblRapid:ENSRNOG00000011865 AllianceGenome:RGD:1585802
    Gene type
    protein coding
    RefSeq status
    INFERRED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam96b; RGD1311762
    Summary
    Predicted to be involved in chromosome segregation; iron-sulfur cluster assembly; and protein maturation by iron-sulfur cluster transfer. Predicted to be located in cytosol; nucleoplasm; and spindle. Predicted to be part of MMXD complex and cytosolic [4Fe-4S] assembly targeting complex. Orthologous to human CIAO2B (cytosolic iron-sulfur assembly component 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 186.1), Muscle (RPKM 139.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ciao2b in Genome Data Viewer
    Location:
    19p14
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (350644..352518)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (344194..346068)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (551708..553573)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene carboxylesterase 2J Neighboring gene mediator complex subunit 29, pseudogene 1 Neighboring gene RRAD, Ras related glycolysis inhibitor and calcium channel regulator Neighboring gene uncharacterized LOC120098574 Neighboring gene cadherin 16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability. Paul VD, et al. Biochim Biophys Acta, 2015 Jun. PMID 25583461
    2. MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation. Ito S, et al. Mol Cell, 2010 Aug 27. PMID 20797633
    3. IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway. Seki M, et al. J Biol Chem, 2013 Jun 7. PMID 23585563, Free PMC Article
    4. MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism. Gari K, et al. Science, 2012 Jul 13. PMID 22678361
    5. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N, et al. Biochim Biophys Acta, 2015 Jun. PMID 25245479, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in iron-sulfur cluster assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein maturation by [4Fe-4S] cluster transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein maturation by iron-sulfur cluster transfer ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MMXD complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic [4Fe-4S] assembly targeting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic [4Fe-4S] assembly targeting complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cytosolic iron-sulfur assembly component 2B
    Names
    family with sequence similarity 96, member B
    mitotic spindle-associated MMXD complex subunit MIP18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144854.1 → NP_001138326.1  cytosolic iron-sulfur assembly component 2B

      Status: INFERRED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      D3Z8Q7
      Related
      ENSRNOP00000015811.4, ENSRNOT00000015811.8
      Conserved Domains (1) summary
      cl00941
      Location:25 → 163
      FeS_assembly_P; Iron-sulfur cluster assembly protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      350644..352518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097978.2 → XP_038953906.1  cytosolic iron-sulfur assembly component 2B isoform X1

      Conserved Domains (1) summary
      cl00941
      Location:25 → 118
      FeS_assembly_P; Iron-sulfur cluster assembly protein
    Nucleotide Protein Strain
    Heading Accession and Version

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