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    Armcx2 armadillo repeat containing, X-linked 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 367903, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Armcx2provided by RGD
    Official Full Name
    armadillo repeat containing, X-linked 2provided by RGD
    Primary source
    RGD:1359132
    See related
    EnsemblRapid:ENSRNOG00000025705 AllianceGenome:RGD:1359132
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Orthologous to human ARMCX2 (armadillo repeat containing X-linked 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 193.5), Uterus (RPKM 59.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Armcx2 in Genome Data Viewer
    Location:
    Xq32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (102273915..102278789, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (97980662..97985523, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (105617383..105622209, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing, X-linked 6 Neighboring gene armadillo repeat containing, X-linked 3 Neighboring gene cofilin 1, pseudogene 2 Neighboring gene small nucleolar RNA SNORA42/SNORA80 family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas. Kurochkin IV, et al. Biochem Biophys Res Commun, 2001 Jan 12. PMID 11162520
    2. Temporal and spatial expression profile of the novel armadillo-related gene, Alex2, during testicular differentiation in the mouse embryo. Smith CA, et al. Dev Dyn, 2005 May. PMID 15759267
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    armadillo repeat-containing X-linked protein 2
    Names
    ALEX2 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014274.1 → NP_001014296.1  armadillo repeat-containing X-linked protein 2

      See identical proteins and their annotated locations for NP_001014296.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081886
      UniProtKB/TrEMBL
      A0A8I5ZLU9, D4A765, Q642B5
      Related
      ENSRNOP00000107846.1, ENSRNOT00000169270.1
      Conserved Domains (3) summary
      cd00020
      Location:518 → 600
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:515 → 764
      Arm_2; Armadillo-like
      sd00044
      Location:529 → 554
      HEAT; HEAT repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      102273915..102278789 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008773429.4 → XP_008771651.1  armadillo repeat-containing X-linked protein 2 isoform X1

      See identical proteins and their annotated locations for XP_008771651.1

      UniProtKB/TrEMBL
      A0A8I5ZLU9, D4A765, Q642B5
      Related
      ENSRNOP00000030098.5, ENSRNOT00000029511.7
      Conserved Domains (3) summary
      cd00020
      Location:518 → 600
      ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
      pfam04826
      Location:515 → 764
      Arm_2; Armadillo-like
      sd00044
      Location:529 → 554
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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