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    Slain2 SLAIN motif family, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305310, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slain2provided by RGD
    Official Full Name
    SLAIN motif family, member 2provided by RGD
    Primary source
    RGD:1311593
    See related
    EnsemblRapid:ENSRNOG00000002271 AllianceGenome:RGD:1311593
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311593
    Summary
    Predicted to be involved in cytoplasmic microtubule organization; microtubule nucleation; and positive regulation of microtubule polymerization. Predicted to be located in centrosome and cytosol. Predicted to colocalize with microtubule plus-end. Orthologous to human SLAIN2 (SLAIN motif family member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 335.6), Muscle (RPKM 244.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Slain2 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (35590050..35667734, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (35236034..35314186, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (37802347..37880571, complement)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene transfer RNA histidin (anticodon AUG) 2 Neighboring gene solute carrier family 10, member 4 Neighboring gene glutathione peroxidase 4, pseudogene 3 Neighboring gene tec protein tyrosine kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SLAIN2 links microtubule plus end-tracking proteins and controls microtubule growth in interphase. van der Vaart B, et al. J Cell Biol, 2011 Jun 13. PMID 21646404, Free PMC Article
    2. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    3. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    4. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, et al. Cardiovasc Res, 2023 Mar 17. PMID 35352799
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of microtubule polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    colocalizes_with microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule plus-end ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SLAIN motif-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107214.1 → NP_001100684.1  SLAIN motif-containing protein 2

      See identical proteins and their annotated locations for NP_001100684.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473981
      UniProtKB/TrEMBL
      A6JD58
      Conserved Domains (1) summary
      pfam15301
      Location:130 → 607
      SLAIN; SLAIN motif-containing family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      35590050..35667734 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273083.1 → XP_063129153.1  SLAIN motif-containing protein 2 isoform X4

    2. XM_017599185.3 → XP_017454674.1  SLAIN motif-containing protein 2 isoform X3

      Conserved Domains (1) summary
      pfam15301
      Location:9 → 486
      SLAIN; SLAIN motif-containing family

    3. XM_006250899.5 → XP_006250961.1  SLAIN motif-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AIE0
      Related
      ENSRNOP00000092872.1, ENSRNOT00000119145.2
      Conserved Domains (1) summary
      pfam15301
      Location:130 → 581
      SLAIN; SLAIN motif-containing family

    4. XM_006250898.5 → XP_006250960.1  SLAIN motif-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      G3V6A2
      Related
      ENSRNOP00000003087.6, ENSRNOT00000003087.7
      Conserved Domains (1) summary
      pfam15301
      Location:130 → 608
      SLAIN; SLAIN motif-containing family
    Nucleotide Protein Strain
    Heading Accession and Version

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