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    Neu1 neuraminidase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24591, updated on 9-Dec-2024

    Summary

    Official Symbol
    Neu1provided by RGD
    Official Full Name
    neuraminidase 1provided by RGD
    Primary source
    RGD:3163
    See related
    EnsemblRapid:ENSRNOG00000032942 AllianceGenome:RGD:3163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables exo-alpha-sialidase activity. Involved in positive regulation of neuron projection development and regulation of myoblast proliferation. Located in cell surface. Human ortholog(s) of this gene implicated in mucolipidosis. Orthologous to human NEU1 (neuraminidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 171.4), Thymus (RPKM 53.9) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Neu1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3902120..3906383, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3897480..3901745, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4610995..4615258)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549726 Neighboring gene small nucleolar RNA, C/D box 48 Neighboring gene small nucleolar RNA, C/D box 52 Neighboring gene uncharacterized LOC120098979 Neighboring gene solute carrier family 44, member 4 Neighboring gene euchromatic histone lysine methyltransferase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-sialidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables exo-alpha-sialidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables exo-alpha-sialidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables exo-alpha-sialidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables exo-alpha-sialidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ganglioside catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oligosaccharide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in oligosaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oligosaccharide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oligosaccharide catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of myoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal lumen IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    sialidase-1
    Names
    N-acetyl-alpha-neuraminidase 1
    lysosomal sialidase
    sialidase 1 (lysosomal sialidase)
    NP_113710.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031522.3NP_113710.2  sialidase-1 precursor

      See identical proteins and their annotated locations for NP_113710.2

      Status: VALIDATED

      Source sequence(s)
      BX883045
      UniProtKB/Swiss-Prot
      Q99PW3
      UniProtKB/TrEMBL
      A0A9K3Y7Q5, D3ZB63, Q6MG70
      Related
      ENSRNOP00000050614.3, ENSRNOT00000049344.7
      Conserved Domains (1) summary
      cd15482
      Location:56404
      Sialidase_non-viral; Non-viral sialidases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      3902120..3906383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)