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    Slc44a4 solute carrier family 44, member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294255, updated on 3-Dec-2024

    Summary

    Official Symbol
    Slc44a4provided by RGD
    Official Full Name
    solute carrier family 44, member 4provided by RGD
    Primary source
    RGD:1303167
    See related
    EnsemblRapid:ENSRNOG00000000878 AllianceGenome:RGD:1303167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ng22
    Summary
    Predicted to enable choline transmembrane transporter activity and thiamine pyrophosphate transmembrane transporter activity. Predicted to be involved in several processes, including acetylcholine biosynthetic process; choline transport; and otolith formation. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 72. Orthologous to human SLC44A4 (solute carrier family 44 member 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 251.8), Lung (RPKM 54.3) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Slc44a4 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3907737..3923911, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3903099..3919215, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4593389..4609641)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549726 Neighboring gene small nucleolar RNA, C/D box 52 Neighboring gene uncharacterized LOC120098979 Neighboring gene neuraminidase 1 Neighboring gene euchromatic histone lysine methyltransferase 2 Neighboring gene zinc finger and BTB domain containing 12 Neighboring gene complement C2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables choline transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables choline transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables organic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables thiamine pyrophosphate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thiamine pyrophosphate transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables thiamine pyrophosphate transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in acetylcholine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in acetylcholine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in acetylcholine secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in acetylcholine secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in choline transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in choline transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in choline transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuromast hair cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in organic cation transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in otolith formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in thiamine pyrophosphate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in thiamine pyrophosphate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in thiamine pyrophosphate transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    choline transporter-like protein 4
    Names
    thiamine pyrophosphate transporter 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212541.1NP_997706.1  choline transporter-like protein 4

      See identical proteins and their annotated locations for NP_997706.1

      Status: VALIDATED

      Source sequence(s)
      BX883045
      UniProtKB/Swiss-Prot
      Q6MG71
      UniProtKB/TrEMBL
      A0A8I5ZM85
      Related
      ENSRNOP00000001174.4, ENSRNOT00000001174.7
      Conserved Domains (1) summary
      pfam04515
      Location:311671
      Choline_transpo; Plasma-membrane choline transporter

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      3907737..3923911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279012.1XP_063135082.1  choline transporter-like protein 4 isoform X1

      UniProtKB/Swiss-Prot
      Q6MG71
      UniProtKB/TrEMBL
      A0A8I5ZM85