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    Atp6v1g2 ATPase H+ transporting V1 subunit G2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 368044, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Atp6v1g2provided by RGD
    Official Full Name
    ATPase H+ transporting V1 subunit G2provided by RGD
    Primary source
    RGD:1303186
    See related
    EnsemblRapid:ENSRNOG00000000840 AllianceGenome:RGD:1303186
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NG38; ATP6G; Atp6g2
    Summary
    Predicted to enable ATP hydrolysis activity and proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in synaptic vesicle lumen acidification. Is extrinsic component of synaptic vesicle membrane. Orthologous to human ATP6V1G2 (ATPase H+ transporting V1 subunit G2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 681.2) and Heart (RPKM 52.0) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp6v1g2 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (3592374..3595986, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (3587681..3591309, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4821265..4824829, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene DExD-box helicase 39B Neighboring gene Small nucleolar RNA SNORD83 Neighboring gene small nucleolar RNA SNORD83 Neighboring gene NFKB inhibitor like 1 Neighboring gene lymphotoxin alpha Neighboring gene tumor necrosis factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Does the rat have an H2-D orthologue next to Bat1? Lambracht-Washington D, et al. Immunogenetics, 2002 Mar. PMID 11904681
    2. Differential localization of the vacuolar H+ pump with G subunit isoforms (G1 and G2) in mouse neurons. Murata Y, et al. J Biol Chem, 2002 Sep 27. PMID 12133826
    3. Structure of V-ATPase from the mammalian brain. Abbas YM, et al. Science, 2020 Mar 13. PMID 32165585, Free PMC Article
    4. Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits. Sun-Wada GH, et al. Gene, 2003 Jan 2. PMID 12527205
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables P-type proton-exporting transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton transmembrane transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in synaptic vesicle lumen acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle lumen acidification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extrinsic component of synaptic vesicle membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in extrinsic component of synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of vacuolar proton-transporting V-type ATPase, V1 domain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    V-type proton ATPase subunit G 2
    Names
    ATPase, H+ transporting, V1 subunit G
    ATPase, H+ transporting, lysosomal V1 subunit G2
    lysosomal ATPase
    vacuolar ATPase NG38
    NP_997655.1
    XP_008770957.1
    XP_038954849.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212490.2 → NP_997655.1  V-type proton ATPase subunit G 2

      See identical proteins and their annotated locations for NP_997655.1

      Status: VALIDATED

      Source sequence(s)
      BX883046
      UniProtKB/TrEMBL
      F7EMR7, Q8R2H0
      Related
      ENSRNOP00000001114.2, ENSRNOT00000001114.7
      Conserved Domains (1) summary
      pfam03179
      Location:3 → 107
      V-ATPase_G; Vacuolar (H+)-ATPase G subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      3592374..3595986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772735.4 → XP_008770957.1  V-type proton ATPase subunit G 2 isoform X1

      See identical proteins and their annotated locations for XP_008770957.1

      UniProtKB/TrEMBL
      A0A0G2KAG3
      Conserved Domains (1) summary
      cl03922
      Location:1 → 66
      V-ATPase_G; Vacuolar (H+)-ATPase G subunit

    2. XM_039098921.2 → XP_038954849.1  V-type proton ATPase subunit G 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2KAG3
      Conserved Domains (1) summary
      cl03922
      Location:1 → 66
      V-ATPase_G; Vacuolar (H+)-ATPase G subunit
    Nucleotide Protein Strain
    Heading Accession and Version

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