Rnf41 ring finger protein 41 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnf41provided by RGD
Official Full Name: ring finger protein 41provided by RGD
Primary source: RGD:1309557
See related: EnsemblRapid:ENSRNOG00000086706 AllianceGenome:RGD:1309557
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including identical protein binding activity; signaling receptor binding activity; and small GTPase binding activity. Predicted to be involved in several processes, including extrinsic apoptotic signaling pathway; positive regulation of reactive oxygen species metabolic process; and protein autoubiquitination. Predicted to act upstream of or within several processes, including negative regulation of mitophagy; regulation of hemopoiesis; and regulation of intracellular signal transduction. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in endoplasmic reticulum tubular network. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human RNF41 (ring finger protein 41). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 159.5), Adrenal (RPKM 132.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (1422651..1461700)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (838160..876869)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (2827242..2854230)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of the Nrdp1 in Brain Injury Induced by Chronic Intermittent Hypoxia in Rats via Regulating the Protein Levels of ErbB3.
Title: Role of the Nrdp1 in Brain Injury Induced by Chronic Intermittent Hypoxia in Rats via Regulating the Protein Levels of ErbB3.
Nrdp1 serves an important role in regulating the apoptosis induced by cardiopulmonary bypass in vivo and in vitro through regulating ErbB3 and phosphoAKT protein levels.
Title: Nrdp1 is involved in hippocampus apoptosis in cardiopulmonary bypass-induced cognitive dysfunction via the regulation of ErbB3 protein levels.
Pathway network analysis identified myocardial metabolism, DNA replication, and the cell cycle as the most important pathways targeted by Nrdp1.
Title: Transcriptional Effects of E3 Ligase Nrdp1 on Hypertrophy in Neonatal Rat Cardiomyocytes by Microarray and Integrated Gene Network Analysis.
The expression of Rnf41 was significantly increased in the cerebral cortex in a neuroinflammation model.
Title: Nrdp1 is Associated with Neuronal Apoptosis in Lipopolysaccharide-Induced Neuroinflammation.

Submit: New GeneRIF Correction

General gene information

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Markers

RH129450 (e-PCR)
- UniSTS:212756

AV071699 (e-PCR)
- UniSTS:165672

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables erythropoietin receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables interleukin-3 receptor binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables receptor tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mitophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein polyubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of lymphocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of myeloid cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum tubular network	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum tubular network	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase NRDP1

NP_001012195.1

EC 6.3.2.38

NP_001387996.1

EC 6.3.2.38

NP_001387997.1

EC 6.3.2.38

NP_001387998.1

EC 6.3.2.38

XP_006240838.1

EC 6.3.2.38

XP_038935300.1

EC 6.3.2.38

XP_038935301.1

EC 6.3.2.38

XP_038935303.1

EC 6.3.2.38

XP_038935304.1

EC 6.3.2.38

XP_038935305.1

EC 6.3.2.38

XP_063119773.1

EC 6.3.2.38

XP_063119774.1

EC 6.3.2.38

XP_063119775.1

EC 6.3.2.38

XP_063119776.1

EC 6.3.2.38

XP_063119777.1

EC 6.3.2.38

XP_063119778.1

EC 6.3.2.38

XP_063119779.1

EC 6.3.2.38

XP_063119780.1

EC 6.3.2.38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012195.1 → NP_001012195.1 E3 ubiquitin-protein ligase NRDP1 isoform 2

See identical proteins and their annotated locations for NP_001012195.1

Status: PROVISIONAL

Source sequence(s)

BC083614

UniProtKB/TrEMBL

A0A0G2K4P8, A0A8J8XH25

Related

ENSRNOP00000105032.1, ENSRNOT00000141904.1

Conserved Domains (2) summary

pfam08941
Location:117 → 295

USP8_interact; USP8 interacting

cl17238
Location:15 → 37

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
NM_001401067.1 → NP_001387996.1 E3 ubiquitin-protein ligase NRDP1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A0G2K4P8, A6KSD2, G3V930, Q5XIR0
NM_001401068.1 → NP_001387997.1 E3 ubiquitin-protein ligase NRDP1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A0G2K4P8, A6KSD2, G3V930, Q5XIR0
NM_001401069.1 → NP_001387998.1 E3 ubiquitin-protein ligase NRDP1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A0G2K4P8, A6KSD2, G3V930, Q5XIR0

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

1422651..1461700

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079375.2 → XP_038935303.1 E3 ubiquitin-protein ligase NRDP1 isoform X2

UniProtKB/TrEMBL

A0A0G2K4P8, A0A8J8XH25

Conserved Domains (2) summary

pfam08941
Location:117 → 295

USP8_interact; USP8 interacting

cl17238
Location:15 → 37

RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
XM_063263706.1 → XP_063119776.1 E3 ubiquitin-protein ligase NRDP1 isoform X1

UniProtKB/TrEMBL

A0A0G2K4P8, A6KSD2, G3V930, Q5XIR0
XM_006240776.5 → XP_006240838.1 E3 ubiquitin-protein ligase NRDP1 isoform X1

See identical proteins and their annotated locations for XP_006240838.1

UniProtKB/TrEMBL

A0A0G2K4P8, A6KSD2, G3V930, Q5XIR0

Related

ENSRNOP00000034376.5, ENSRNOT00000029778.6

Conserved Domains (2) summary

cd16634
Location:15 → 57

mRING-HC-C3HC3D_Nrdp1; Modified RING finger, HC subclass (C3HC3D-type), found in neuregulin receptor degradation protein-1 (Nrdp1) and similar proteins

pfam08941
Location:137 → 315

USP8_interact; USP8 interacting
XM_063263705.1 → XP_063119775.1 E3 ubiquitin-protein ligase NRDP1 isoform X1

UniProtKB/TrEMBL

A0A0G2K4P8, A6KSD2, G3V930, Q5XIR0
XM_063263708.1 → XP_063119778.1 E3 ubiquitin-protein ligase NRDP1 isoform X2

UniProtKB/TrEMBL

A0A0G2K4P8, A0A8J8XH25
XM_039079373.2 → XP_038935301.1 E3 ubiquitin-protein ligase NRDP1 isoform X1

UniProtKB/TrEMBL

A0A0G2K4P8, A6KSD2, G3V930, Q5XIR0

Conserved Domains (2) summary

cd16634
Location:15 → 57

mRING-HC-C3HC3D_Nrdp1; Modified RING finger, HC subclass (C3HC3D-type), found in neuregulin receptor degradation protein-1 (Nrdp1) and similar proteins

pfam08941
Location:137 → 315

USP8_interact; USP8 interacting
XM_039079372.2 → XP_038935300.1 E3 ubiquitin-protein ligase NRDP1 isoform X1

UniProtKB/TrEMBL

A0A0G2K4P8, A6KSD2, G3V930, Q5XIR0

Conserved Domains (2) summary

cd16634
Location:15 → 57

mRING-HC-C3HC3D_Nrdp1; Modified RING finger, HC subclass (C3HC3D-type), found in neuregulin receptor degradation protein-1 (Nrdp1) and similar proteins

pfam08941
Location:137 → 315

USP8_interact; USP8 interacting
XM_063263709.1 → XP_063119779.1 E3 ubiquitin-protein ligase NRDP1 isoform X2

UniProtKB/TrEMBL

A0A0G2K4P8, A0A8J8XH25
XM_063263704.1 → XP_063119774.1 E3 ubiquitin-protein ligase NRDP1 isoform X1

UniProtKB/TrEMBL

A0A0G2K4P8, A6KSD2, G3V930, Q5XIR0
XM_063263710.1 → XP_063119780.1 E3 ubiquitin-protein ligase NRDP1 isoform X2

UniProtKB/TrEMBL

A0A0G2K4P8, A0A8J8XH25
XM_063263707.1 → XP_063119777.1 E3 ubiquitin-protein ligase NRDP1 isoform X2

UniProtKB/TrEMBL

A0A0G2K4P8, A0A8J8XH25
XM_063263703.1 → XP_063119773.1 E3 ubiquitin-protein ligase NRDP1 isoform X1

UniProtKB/TrEMBL

A0A0G2K4P8, A6KSD2, G3V930, Q5XIR0
XM_039079376.2 → XP_038935304.1 E3 ubiquitin-protein ligase NRDP1 isoform X3

Conserved Domains (1) summary

pfam08941
Location:14 → 192

USP8_interact; USP8 interacting
XM_039079377.2 → XP_038935305.1 E3 ubiquitin-protein ligase NRDP1 isoform X3

Conserved Domains (1) summary

pfam08941
Location:14 → 192

USP8_interact; USP8 interacting