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    Hsf2 heat shock transcription factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64441, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hsf2provided by RGD
    Official Full Name
    heat shock transcription factor 2provided by RGD
    Primary source
    RGD:68395
    See related
    EnsemblRapid:ENSRNOG00000000808 AllianceGenome:RGD:68395
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II and spermatogenesis. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Orthologous to human HSF2 (heat shock transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 138.9), Testes (RPKM 107.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hsf2 in Genome Data Viewer
    Location:
    20q12
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (37366301..37393922)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (36819864..36847490)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (38935820..38963444)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene twinfilin, actin-binding protein, homolog 2 (Drosophila), pseudogene 1 Neighboring gene uncharacterized LOC108349075 Neighboring gene serine incorporator 1 Neighboring gene uncharacterized LOC134483929 Neighboring gene cAMP-dependent protein kinase inhibitor beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Heat shock transcription factor HSF2 modulates the autophagy response through the BTG2-SOD2 axis. Kanugovi Vijayavittal A, et al. Biochem Biophys Res Commun, 2022 Apr 16. PMID 35182974
    2. p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure. Huang CY, et al. Cell Death Dis, 2017 Aug 10. PMID 28796250, Free PMC Article
    3. Heat shock transcription factors regulate heat induced cell death in a rat histiocytoma. Prasad KV, et al. J Biosci, 2007 Apr. PMID 17536178
    4. Co-expression of heat shock transcription factors 1 and 2 in rat retinal ganglion cells. Kwong JM, et al. Neurosci Lett, 2006 Sep 25. PMID 16889897
    5. Regulation of rat heat shock factor 2 expression during the early organogenic phase of embryogenesis. Min JN, et al. Biochim Biophys Acta, 2000 Dec 1. PMID 11121583

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Heat shock transcription factor HSF2 modulates the autophagy response through the BTG2-SOD2 axis.
      Title: Heat shock transcription factor HSF2 modulates the autophagy response through the BTG2-SOD2 axis.
    2. p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure
      Title: p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure.
    3. DOX induced mitochondrial ROS release to activate ERK1/2-mediated HSF2 nuclear translocation and AT1 R upregulation causing DOX-damaged heart failure in vitro and in vivo.
      Title: Mitochondrial ROS-induced ERK1/2 activation and HSF2-mediated AT(1) R upregulation are required for doxorubicin-induced cardiotoxicity.
    4. The Hsf2 is mainly expressed in round spermatids in control testis. Hsf2 expression is significantly increased in both nuclei and cytoplasm of spermatocytes in 7-day cryptorchid testis.
      Title: Expression of Hsf1, Hsf2, and Phlda1 in cells undergoing cryptorchid-induced apoptosis in rat testes.
    5. Compromising HSF2 expression but not HSF1 resulted in the inhibition of autophagy, suggesting HSF2 dependent activation of autophagy in BC-8 cells.
      Title: Heat shock transcription factors regulate heat induced cell death in a rat histiocytoma.
    6. both heat shock transcription 2 is linked to the heat shock response in retinal ganglion cells.
      Title: Co-expression of heat shock transcription factors 1 and 2 in rat retinal ganglion cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    heat shock factor protein 2
    Names
    heat shock factor 2
    heat shock transcription factor hsf2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001434554.1 → NP_001421483.1  heat shock factor protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020

    2. NM_001434556.1 → NP_001421485.1  heat shock factor protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020

    3. NM_001434557.1 → NP_001421486.1  heat shock factor protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020

    4. NM_031694.3 → NP_113882.1  heat shock factor protein 2 isoform 1

      See identical proteins and their annotated locations for NP_113882.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A9K3Y8F3, A6K4B9, F1LQD4, Q9R120
      Related
      ENSRNOP00000001059.4, ENSRNOT00000001059.6
      Conserved Domains (2) summary
      smart00415
      Location:6 → 110
      HSF; heat shock factor
      pfam06546
      Location:230 → 489
      Vert_HS_TF; Vertebrate heat shock transcription factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      37366301..37393922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601769.3 → XP_017457258.1  heat shock factor protein 2 isoform X2

      UniProtKB/TrEMBL
      A6K4C0
      Related
      ENSRNOP00000085150.2, ENSRNOT00000101061.2
      Conserved Domains (2) summary
      smart00415
      Location:1 → 53
      HSF; heat shock factor
      pfam06546
      Location:173 → 450
      Vert_HS_TF; Vertebrate heat shock transcription factor

    2. XM_006256505.5 → XP_006256567.1  heat shock factor protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZYL7, A6K4B9
      Related
      ENSRNOP00000102980.1, ENSRNOT00000169499.1
      Conserved Domains (2) summary
      smart00415
      Location:6 → 110
      HSF; heat shock factor
      pfam06546
      Location:230 → 507
      Vert_HS_TF; Vertebrate heat shock transcription factor

    3. XM_006256506.5 → XP_006256568.1  heat shock factor protein 2 isoform X2

      UniProtKB/TrEMBL
      A6K4C0
      Conserved Domains (2) summary
      smart00415
      Location:1 → 53
      HSF; heat shock factor
      pfam06546
      Location:173 → 450
      Vert_HS_TF; Vertebrate heat shock transcription factor
    Nucleotide Protein Strain
    Heading Accession and Version

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