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    Nxf7 nuclear RNA export factor 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 501621, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nxf7provided by RGD
    Official Full Name
    nuclear RNA export factor 7provided by RGD
    Primary source
    RGD:1566170
    See related
    EnsemblRapid:ENSRNOG00000023256 AllianceGenome:RGD:1566170
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to act upstream of or within RNA export from nucleus. Predicted to be located in cytoplasm and nuclear envelope. Predicted to be active in nucleus. Orthologous to human NXF2 (nuclear RNA export factor 2); NXF2B (nuclear RNA export factor 2B); and NXF5 (nuclear RNA export factor 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 71.7) See more
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    Genomic context

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    See Nxf7 in Genome Data Viewer
    Location:
    Xq32
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (102828592..102845799, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (98535374..98552562, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (106049075..106066334, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene non-histone chromosomal protein HMG-14-like Neighboring gene preferentially expressed antigen in melanoma-like Neighboring gene PRAME like, X-linked 1 Neighboring gene t-complex 11 family, X-linked 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of the mouse nuclear export factor (Nxf) family members. Tan W, et al. Nucleic Acids Res, 2005. PMID 16027110, Free PMC Article
    2. NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. Jun L, et al. Curr Biol, 2001 Sep 18. PMID 11566096
    3. Molecular cloning and functional characterization of mouse Nxf family gene products. Sasaki M, et al. Genomics, 2005 May. PMID 15820316
    4. Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Besche HC, et al. Biochemistry, 2009 Mar 24. PMID 19182904, Free PMC Article
    5. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114500

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in poly(A)+ mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within poly(A)+ mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nuclear RNA export factor 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037216.2 → NP_001032293.1  nuclear RNA export factor 7

      See identical proteins and their annotated locations for NP_001032293.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      F7FPN7, Q498M8
      Related
      ENSRNOP00000038474.6, ENSRNOT00000033752.6
      Conserved Domains (5) summary
      smart00804
      Location:549 → 611
      TAP_C; C-terminal domain of vertebrate Tap protein
      sd00035
      Location:217 → 259
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam09162
      Location:110 → 191
      Tap-RNA_bind; Tap, RNA-binding
      pfam13855
      Location:258 → 320
      LRR_8; Leucine rich repeat
      cl09109
      Location:380 → 531
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

    2. NM_001434343.1 → NP_001421272.1  nuclear RNA export factor 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    3. NM_001434344.1 → NP_001421273.1  nuclear RNA export factor 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      102828592..102845799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006257254.5 → XP_006257316.1  nuclear RNA export factor 7 isoform X1

      UniProtKB/TrEMBL
      F7FPN7, Q498M8
      Conserved Domains (5) summary
      smart00804
      Location:549 → 611
      TAP_C; C-terminal domain of vertebrate Tap protein
      sd00035
      Location:217 → 259
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam09162
      Location:110 → 191
      Tap-RNA_bind; Tap, RNA-binding
      pfam13855
      Location:258 → 320
      LRR_8; Leucine rich repeat
      cl09109
      Location:380 → 531
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

    2. XM_039099981.2 → XP_038955909.1  nuclear RNA export factor 7 isoform X1

      UniProtKB/TrEMBL
      F7FPN7, Q498M8
      Conserved Domains (5) summary
      smart00804
      Location:549 → 611
      TAP_C; C-terminal domain of vertebrate Tap protein
      sd00035
      Location:217 → 259
      LRR_NTF; leucine-rich repeat [structural motif]
      pfam09162
      Location:110 → 191
      Tap-RNA_bind; Tap, RNA-binding
      pfam13855
      Location:258 → 320
      LRR_8; Leucine rich repeat
      cl09109
      Location:380 → 531
      NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...
    Nucleotide Protein Strain
    Heading Accession and Version

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