Mavs mitochondrial antiviral signaling protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mavsprovided by RGD
Official Full Name: mitochondrial antiviral signaling proteinprovided by RGD
Primary source: RGD:1359371
See related: EnsemblRapid:ENSRNOG00000025295 AllianceGenome:RGD:1359371
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Visa
Summary: Predicted to enable several functions, including CARD domain binding activity; RIG-I binding activity; and molecular condensate scaffold activity. Predicted to be involved in several processes, including positive regulation of cytokine production; regulation of DNA-templated transcription; and regulation of defense response. Predicted to act upstream of or within RIG-I signaling pathway and positive regulation of type I interferon production. Predicted to be located in mitochondrion and peroxisomal membrane. Predicted to be active in mitochondrial outer membrane. Orthologous to human MAVS (mitochondrial antiviral signaling protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 135.8), Kidney (RPKM 103.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q36

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (138904673..138919129)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (118451650..118466094)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (123776147..123790572)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

AI502240 (e-PCR)
- UniSTS:261507

RH139303 (e-PCR)
- UniSTS:221389

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CARD domain binding	ISO Inferred from Sequence Orthology more info
enables RIG-I binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular condensate scaffold activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RIG-I signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in activation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info
involved_in cellular response to exogenous dsRNA	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoplasmic pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_positive_effect innate immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of IP-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of chemokine (C-C motif) ligand 5 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-alpha production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myeloid dendritic cell cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myeloid dendritic cell cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of response to cytokine stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in regulation of peroxisome organization	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial antiviral-signaling protein

Names: IPS-1; interferon beta promoter stimulator protein 1; virus-induced signaling adaptor; virus-induced-signaling adapter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005556.1 → NP_001005556.1 mitochondrial antiviral-signaling protein

See identical proteins and their annotated locations for NP_001005556.1

Status: PROVISIONAL

Source sequence(s)

BC081869

UniProtKB/Swiss-Prot

Q66HG9

UniProtKB/TrEMBL

A0A8L2QH64, A6HQD4

Conserved Domains (2) summary

PHA03247
Location:65 → 468

PHA03247; large tegument protein UL36; Provisional

cd08811
Location:3 → 93

CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

138904673..138919129

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063283781.1 → XP_063139851.1 mitochondrial antiviral-signaling protein isoform X2
XM_006235034.4 → XP_006235096.1 mitochondrial antiviral-signaling protein isoform X1

See identical proteins and their annotated locations for XP_006235096.1

UniProtKB/Swiss-Prot

Q66HG9

UniProtKB/TrEMBL

A0A8L2QH64, A6HQD4

Conserved Domains (2) summary

PHA03247
Location:65 → 468

PHA03247; large tegument protein UL36; Provisional

cd08811
Location:3 → 93

CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1
XM_063283775.1 → XP_063139845.1 mitochondrial antiviral-signaling protein isoform X1

UniProtKB/Swiss-Prot

Q66HG9

UniProtKB/TrEMBL

A6HQD4
XM_006235035.5 → XP_006235097.1 mitochondrial antiviral-signaling protein isoform X1

See identical proteins and their annotated locations for XP_006235097.1

UniProtKB/Swiss-Prot

Q66HG9

UniProtKB/TrEMBL

A0A8L2QH64, A6HQD4

Conserved Domains (2) summary

PHA03247
Location:65 → 468

PHA03247; large tegument protein UL36; Provisional

cd08811
Location:3 → 93

CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1
XM_006235036.4 → XP_006235098.1 mitochondrial antiviral-signaling protein isoform X1

See identical proteins and their annotated locations for XP_006235098.1

UniProtKB/Swiss-Prot

Q66HG9

UniProtKB/TrEMBL

A0A8L2QH64, A6HQD4

Related

ENSRNOP00000073053.1, ENSRNOT00000090764.3

Conserved Domains (2) summary

PHA03247
Location:65 → 468

PHA03247; large tegument protein UL36; Provisional

cd08811
Location:3 → 93

CARD_IPS1; Caspase activation and recruitment domain (CARD) found in IPS-1
XM_063283779.1 → XP_063139849.1 mitochondrial antiviral-signaling protein isoform X2
XM_063283776.1 → XP_063139846.1 mitochondrial antiviral-signaling protein isoform X1

UniProtKB/Swiss-Prot

Q66HG9

UniProtKB/TrEMBL

A6HQD4
XM_039105011.2 → XP_038960939.1 mitochondrial antiviral-signaling protein isoform X3

Conserved Domains (2) summary

PHA03247
Location:10 → 298

PHA03247; large tegument protein UL36; Provisional

NF033645
Location:98 → 240

pilus_FilE; putative pilus assembly protein FilE
XM_063283778.1 → XP_063139848.1 mitochondrial antiviral-signaling protein isoform X1

UniProtKB/Swiss-Prot

Q66HG9

UniProtKB/TrEMBL

A6HQD4
XM_006235037.5 → XP_006235099.1 mitochondrial antiviral-signaling protein isoform X3

Conserved Domains (2) summary

PHA03247
Location:10 → 298

PHA03247; large tegument protein UL36; Provisional

NF033645
Location:98 → 240

pilus_FilE; putative pilus assembly protein FilE
XM_063283782.1 → XP_063139852.1 mitochondrial antiviral-signaling protein isoform X4
XM_063283780.1 → XP_063139850.1 mitochondrial antiviral-signaling protein isoform X2
XM_063283774.1 → XP_063139844.1 mitochondrial antiviral-signaling protein isoform X1

UniProtKB/Swiss-Prot

Q66HG9

UniProtKB/TrEMBL

A6HQD4