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    Utp20 UTP20 small subunit processome component [ Mus musculus (house mouse) ]

    Gene ID: 70683, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Utp20provided by MGI
    Official Full Name
    UTP20 small subunit processome componentprovided by MGI
    Primary source
    MGI:MGI:1917933
    See related
    Ensembl:ENSMUSG00000004356 AllianceGenome:MGI:1917933
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Drim; mDRIM; mDRIN; 3830408P06Rik
    Summary
    Predicted to be involved in rRNA processing and ribosomal small subunit biogenesis. Predicted to be located in plasma membrane. Predicted to be part of 90S preribosome and small-subunit processome. Predicted to be active in nucleolus. Is expressed in cerebellum; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human UTP20 (UTP20 small subunit processome component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 4.2), limb E14.5 (RPKM 2.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Utp20 in Genome Data Viewer
    Location:
    10 C1; 10 44.21 cM
    Exon count:
    62
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (88582469..88662676, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (88746607..88826814, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27509 Neighboring gene STARR-positive B cell enhancer ABC_E11454 Neighboring gene predicted gene, 46192 Neighboring gene predicted gene 4925 Neighboring gene STARR-seq mESC enhancer starr_27512 Neighboring gene ADP-ribosylation factor-like 1 Neighboring gene STARR-seq mESC enhancer starr_27513 Neighboring gene solute carrier family 5 (iodide transporter), member 8 Neighboring gene STARR-seq mESC enhancer starr_27514 Neighboring gene STARR-seq mESC enhancer starr_27515 Neighboring gene anoctamin 4 Neighboring gene predicted gene, 30769

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Isolation of novel mouse genes that were differentially expressed in W/W(V) mouse fundus. Daigo Y, et al. J Gastroenterol, 2004. PMID 15065000
    2. Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Varum S, et al. Cell Stem Cell, 2019 Apr 4. PMID 30951662
    3. Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Zurkirchen L, et al. Nat Commun, 2019 May 16. PMID 31097699, Free PMC Article
    4. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    5. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in rRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    small subunit processome component 20 homolog
    Names
    UTP20, small subunit (SSU) processome component, homolog
    down-regulated in metastasis protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175158.3 → NP_780367.2  small subunit processome component 20 homolog

      Status: VALIDATED

      Source sequence(s)
      AC155820, AC164567
      Consensus CDS
      CCDS48667.1
      UniProtKB/Swiss-Prot
      Q5XG71, Q80V22, Q8BXH9, Q8CHL6, Q99K11
      UniProtKB/TrEMBL
      E9QK83
      Related
      ENSMUSP00000004470.8, ENSMUST00000004470.9
      Conserved Domains (1) summary
      pfam07539
      Location:912 → 1531
      DRIM; Down-regulated in metastasis

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      88582469..88662676 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XG71.2 GenPept UniProtKB/Swiss-Prot:Q5XG71

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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