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    Slc22a29 solute carrier family 22. member 29 [ Mus musculus (house mouse) ]

    Gene ID: 236293, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Slc22a29provided by MGI
    Official Full Name
    solute carrier family 22. member 29provided by MGI
    Primary source
    MGI:MGI:3605624
    See related
    Ensembl:ENSMUSG00000075044 AllianceGenome:MGI:3605624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D630002G06Rik
    Summary
    Predicted to enable short-chain fatty acid transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in organic anion transport. Predicted to be located in basolateral plasma membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to several human genes including SLC22A25 (solute carrier family 22 member 25). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 8.6) and liver adult (RPKM 4.6) See more
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    Genomic context

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    See Slc22a29 in Genome Data Viewer
    Location:
    19 A; 19 5.4 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8137532..8230739, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8160168..8253375, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene calpastatin pseudogene Neighboring gene solute carrier family 22, member 28 Neighboring gene STARR-seq mESC enhancer starr_45475 Neighboring gene predicted gene, 41804 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene calpastatin pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members. Wu W, et al. Physiol Genomics, 2009 Jul 9. PMID 19417012, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC143567

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables short-chain fatty acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 22. member 29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347426.1 → NP_001334355.1  solute carrier family 22. member 29 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC110913
      Consensus CDS
      CCDS84413.1
      UniProtKB/TrEMBL
      Q687I5
      Related
      ENSMUST00000140910.8

    2. NM_172776.3 → NP_766364.1  solute carrier family 22. member 29 isoform 1

      See identical proteins and their annotated locations for NP_766364.1

      Status: VALIDATED

      Source sequence(s)
      AC110913, AK052597
      Consensus CDS
      CCDS29535.1
      UniProtKB/TrEMBL
      Q687I4, Q8BWG6
      Related
      ENSMUSP00000108923.3, ENSMUST00000113298.9
      Conserved Domains (1) summary
      cd17374
      Location:109 → 515
      MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      8137532..8230739 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527061.1 → XP_006527124.1  solute carrier family 22. member 29 isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:1 → 308
      MFS; Major Facilitator Superfamily

    2. XM_006527060.4 → XP_006527123.1  solute carrier family 22. member 29 isoform X2

      UniProtKB/TrEMBL
      Q687I5
      Conserved Domains (1) summary
      cl28910
      Location:109 → 454
      MFS; Major Facilitator Superfamily

    3. XM_011247245.3 → XP_011245547.1  solute carrier family 22. member 29 isoform X1

      See identical proteins and their annotated locations for XP_011245547.1

      UniProtKB/TrEMBL
      Q687I4, Q8BWG6
      Conserved Domains (1) summary
      cd17374
      Location:109 → 515
      MFS_OAT; Organic anion transporters of the Major Facilitator Superfamily of transporters
    Nucleotide Protein Strain
    Heading Accession and Version

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