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    KLF7 KLF transcription factor 7 [ Homo sapiens (human) ]

    Gene ID: 8609, updated on 10-Dec-2024

    Summary

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    Official Symbol
    KLF7provided by HGNC
    Official Full Name
    KLF transcription factor 7provided by HGNC
    Primary source
    HGNC:HGNC:6350
    See related
    Ensembl:ENSG00000118263 MIM:604865; AllianceGenome:HGNC:6350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UKLF
    Summary
    The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
    Expression
    Ubiquitous expression in bone marrow (RPKM 4.7), endometrium (RPKM 4.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KLF7 in Genome Data Viewer
    Location:
    2q33.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (207074137..207173851, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (207556313..207657581, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (207938861..208031970, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene FAST kinase domains 2 Neighboring gene microRNA 3130-1 Neighboring gene microRNA 3130-2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:207671457-207672284 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:207676275-207676890 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:207676891-207677508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12270 Neighboring gene carboxypeptidase O Neighboring gene Sharpr-MPRA regulatory region 8398 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:207901421-207902246 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:207902247-207903074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17029 Neighboring gene Sharpr-MPRA regulatory region 11101 Neighboring gene NANOG hESC enhancer GRCh37_chr2:208007006-208007507 Neighboring gene microRNA 2355 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:208013849-208014350 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12271 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:208028265-208028973 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:208028974-208029682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17030 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr2:208030391-208031099 and GRCh37_chr2:208031100-208031807 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:208031808-208032516 Neighboring gene MYOSLID antisense RNA 1 Neighboring gene microRNA 7845 Neighboring gene NANOG hESC enhancer GRCh37_chr2:208064814-208065392 Neighboring gene MPRA-validated peak4025 silencer Neighboring gene uncharacterized LOC124907971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17032 Neighboring gene myocardin-induced smooth muscle lncRNA, inducer of differentiation

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A common cis-element in promoters of protein synthesis and cell cycle genes. Wyrwicz LS, et al. Acta Biochim Pol, 2007. PMID 17351670
    2. High Expression of Krüppel-like Factor 7 Indicates Unfavorable Clinical Outcomes in Patients with Lung Adenocarcinoma. Niu R, et al. J Surg Res, 2020 Jun. PMID 32092599
    3. Decreased Serum Kruppel-Like Factor 7 Level is Positively Associated with Low-Density Lipoprotein Cholesterol Level in Women with Polycystic Ovary Syndrome. Pan G, et al. Clin Lab, 2019 Apr 1. PMID 30969076
    4. Elevated KLF7 levels may serve as a prognostic signature and might contribute to progression of squamous carcinoma. Yang J, et al. FEBS Open Bio, 2020 Aug. PMID 32536035, Free PMC Article
    5. KLF7 promotes macrophage activation by activating the NF-κB signaling pathway in epicardial adipose tissue in patients with coronary artery disease. Huang WH, et al. Eur Rev Med Pharmacol Sci, 2020 Jun. PMID 32633394

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KLF7 promotes neuroblastoma differentiation through the GTPase signaling pathway by upregulating neuroblast differentiation-associated protein AHNAKs and glycerophosphodiesterase GDPD5.
      Title: KLF7 promotes neuroblastoma differentiation through the GTPase signaling pathway by upregulating neuroblast differentiation-associated protein AHNAKs and glycerophosphodiesterase GDPD5.
    2. Newborn adiposity is associated with cord blood DNA methylation at IGF1R and KLF7.
      Title: Newborn adiposity is associated with cord blood DNA methylation at IGF1R and KLF7.
    3. KLF7 enhances the invasion and migration of colorectal cancer cells via the miR-139-5p/TPD52 axis.
      Title: KLF7 enhances the invasion and migration of colorectal cancer cells via the miR-139-5p/TPD52 axis.
    4. UKLF/PCBP2 axis governs the colorectal cancer development by transcriptionally activating SLC39A4.
      Title: UKLF/PCBP2 axis governs the colorectal cancer development by transcriptionally activating SLC39A4.
    5. KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma.
      Title: KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma.
    6. HMGB1-mediated elevation of KLF7 facilitates hepatocellular carcinoma progression and metastasis through upregulating TLR4 and PTK2.
      Title: HMGB1-mediated elevation of KLF7 facilitates hepatocellular carcinoma progression and metastasis through upregulating TLR4 and PTK2.
    7. Molecular function of Kruppel-like factor 7 in biology.
      Title: Molecular function of Krüppel-like factor 7 in biology.
    8. Circular hsa_circ_0020377 regulates KLF7 by targeting miR-194-5p to facilitate tumor cell malignant behaviors and glycolysis in oral squamous cell carcinoma progression.
      Title: Circular hsa_circ_0020377 regulates KLF7 by targeting miR-194-5p to facilitate tumor cell malignant behaviors and glycolysis in oral squamous cell carcinoma progression.
    9. LncRNA NUTM2A-AS1 aggravates the progression of hepatocellular carcinoma by activating the miR-186-5p/KLF7-mediated Wnt/beta-catenin pathway.
      Title: LncRNA NUTM2A-AS1 aggravates the progression of hepatocellular carcinoma by activating the miR-186-5p/KLF7-mediated Wnt/beta-catenin pathway.
    10. Kruppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer.
      Title: Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (37)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axon guidance ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within dendrite morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of epidermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Krueppel-like factor 7
    Names
    Kruppel like factor 7
    Kruppel-like factor 7 (ubiquitous)
    ubiquitous Kruppel-like factor
    ubiquitous Kruppel-like transcription factor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052989.2 RefSeqGene

      Range
      12903..104714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001270942.1 → NP_001257871.1  Krueppel-like factor 7 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate splice site in the coding region that results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC008062, BC012919, DA800775
      Consensus CDS
      CCDS59439.1
      UniProtKB/Swiss-Prot
      O75840
      Related
      ENSP00000398572.1, ENST00000423015.5

    2. NM_001270943.2 → NP_001257872.1  Krueppel-like factor 7 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The resulting protein (isoform 3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC007879, AC008062
      Consensus CDS
      CCDS59440.1
      UniProtKB/TrEMBL
      Q4ZG79
      Related
      ENSP00000387510.1, ENST00000421199.5
      Conserved Domains (3) summary
      COG5048
      Location:179 → 251
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:191 → 210
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:246 → 268
      zf-C2H2; Zinc finger, C2H2 type

    3. NM_001270944.2 → NP_001257873.1  Krueppel-like factor 7 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC007879, AC008062
      Consensus CDS
      CCDS59438.1
      UniProtKB/TrEMBL
      Q4ZG79
      Related
      ENSP00000413590.2, ENST00000435602.2
      Conserved Domains (3) summary
      COG5048
      Location:184 → 256
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:196 → 215
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:251 → 273
      zf-C2H2; Zinc finger, C2H2 type

    4. NM_003709.4 → NP_003700.1  Krueppel-like factor 7 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC007879, AC008062
      Consensus CDS
      CCDS2373.1
      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6
      Related
      ENSP00000309570.6, ENST00000309446.11
      Conserved Domains (5) summary
      COG5048
      Location:212 → 284
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:224 → 243
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:279 → 301
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:265 → 290
      zf-H2C2_2; Zinc-finger double domain
      cd21585
      Location:2 → 220
      KLF7_N; N-terminal domain of Kruppel-like factor 7

    RNA

    1. NR_073108.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains an alternate 5' exon and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC008062, DA023826

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      207074137..207173851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047446149.1 → XP_047302105.1  Krueppel-like factor 7 isoform X3

      UniProtKB/TrEMBL
      Q4ZG79

    2. XM_047446146.1 → XP_047302102.1  Krueppel-like factor 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6

    3. XM_047446145.1 → XP_047302101.1  Krueppel-like factor 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6

    4. XM_047446147.1 → XP_047302103.1  Krueppel-like factor 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6

    5. XM_047446144.1 → XP_047302100.1  Krueppel-like factor 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6

    6. XM_017005161.2 → XP_016860650.1  Krueppel-like factor 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6
      Conserved Domains (5) summary
      COG5048
      Location:212 → 284
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:224 → 243
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:279 → 301
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:265 → 290
      zf-H2C2_2; Zinc-finger double domain
      cd21585
      Location:2 → 220
      KLF7_N; N-terminal domain of Kruppel-like factor 7

    7. XM_017005164.3 → XP_016860653.1  Krueppel-like factor 7 isoform X5

      UniProtKB/Swiss-Prot
      O75840
      Related
      ENSP00000515454.1, ENST00000703734.1

    8. XM_047446148.1 → XP_047302104.1  Krueppel-like factor 7 isoform X2

      UniProtKB/TrEMBL
      Q4ZG79

    9. XM_011512075.3 → XP_011510377.1  Krueppel-like factor 7 isoform X4

      UniProtKB/TrEMBL
      A0A994J6Y4
      Conserved Domains (2) summary
      sd00017
      Location:221 → 243
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:219 → 243
      zf-C2H2; Zinc finger, C2H2 type

    10. XM_047446150.1 → XP_047302106.1  Krueppel-like factor 7 isoform X4

      UniProtKB/TrEMBL
      A0A994J6Y4

    RNA

    1. XR_923051.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      207556313..207657581 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344310.1 → XP_054200285.1  Krueppel-like factor 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6

    2. XM_054344311.1 → XP_054200286.1  Krueppel-like factor 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6

    3. XM_054344313.1 → XP_054200288.1  Krueppel-like factor 7 isoform X3

      UniProtKB/TrEMBL
      Q4ZG79

    4. XM_054344309.1 → XP_054200284.1  Krueppel-like factor 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6

    5. XM_054344308.1 → XP_054200283.1  Krueppel-like factor 7 isoform X1

      UniProtKB/Swiss-Prot
      B2RB03, B7Z4F7, C9JF04, E7EWH1, L0R4P2, O75840, Q7Z3H8, Q96E51
      UniProtKB/TrEMBL
      B3KNE6

    6. XM_054344316.1 → XP_054200291.1  Krueppel-like factor 7 isoform X5

    7. XM_054344312.1 → XP_054200287.1  Krueppel-like factor 7 isoform X2

      UniProtKB/TrEMBL
      Q4ZG79

    8. XM_054344314.1 → XP_054200289.1  Krueppel-like factor 7 isoform X4

      UniProtKB/TrEMBL
      A0A994J6Y4

    9. XM_054344315.1 → XP_054200290.1  Krueppel-like factor 7 isoform X4

      UniProtKB/TrEMBL
      A0A994J6Y4

    RNA

    1. XR_008486574.1 RNA Sequence

    2. XR_008486573.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75840.1 GenPept UniProtKB/Swiss-Prot:O75840

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