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    TMEM267 transmembrane protein 267 [ Homo sapiens (human) ]

    Gene ID: 64417, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TMEM267provided by HGNC
    Official Full Name
    transmembrane protein 267provided by HGNC
    Primary source
    HGNC:HGNC:26139
    See related
    Ensembl:ENSG00000151881 AllianceGenome:HGNC:26139
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C5orf28
    Summary
    Predicted to be located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thyroid (RPKM 13.3), prostate (RPKM 2.9) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM267 in Genome Data Viewer
    Location:
    5p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (43444252..43484387, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (43697085..43737220, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (43444354..43484489, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene 60S acidic ribosomal protein P1-like Neighboring gene C-C motif chemokine ligand 28 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15993 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15994 Neighboring gene Sharpr-MPRA regulatory region 10963 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:43483998-43484841 Neighboring gene C5orf34 antisense RNA 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85282 Neighboring gene chromosome 5 open reading frame 34 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 19 Neighboring gene uncharacterized LOC124900190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22540

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Systematic identification of pathological lamin A interactors. Dittmer TA, et al. Mol Biol Cell, 2014 May. PMID 24623722, Free PMC Article
    2. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article
    3. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
    4. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Maruyama K, et al. Gene, 1994 Jan 28. PMID 8125298
    5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21657, MGC90226, MGC149524

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 267
    Names
    transmembrane protein C5orf28

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001377394.1 → NP_001364323.1  transmembrane protein 267

      Status: VALIDATED

      Source sequence(s)
      AC025457
      Consensus CDS
      CCDS3945.1
      UniProtKB/Swiss-Prot
      B2RDA6, Q0VDI3, Q9H6Z2
      UniProtKB/TrEMBL
      D6RAV6
      Related
      ENSP00000422881.1, ENST00000512085.5

    2. NM_001377395.1 → NP_001364324.1  transmembrane protein 267

      Status: VALIDATED

      Source sequence(s)
      AC025457
      Consensus CDS
      CCDS3945.1
      UniProtKB/Swiss-Prot
      B2RDA6, Q0VDI3, Q9H6Z2
      UniProtKB/TrEMBL
      D6RAV6

    3. NM_001377396.1 → NP_001364325.1  transmembrane protein 267

      Status: VALIDATED

      Source sequence(s)
      AC025457
      Consensus CDS
      CCDS3945.1
      UniProtKB/Swiss-Prot
      B2RDA6, Q0VDI3, Q9H6Z2
      UniProtKB/TrEMBL
      D6RAV6

    4. NM_001377397.1 → NP_001364326.1  transmembrane protein 267

      Status: VALIDATED

      Source sequence(s)
      AC025457
      Consensus CDS
      CCDS3945.1
      UniProtKB/Swiss-Prot
      B2RDA6, Q0VDI3, Q9H6Z2
      UniProtKB/TrEMBL
      D6RAV6

    5. NM_001377398.1 → NP_001364327.1  transmembrane protein 267

      Status: VALIDATED

      Source sequence(s)
      AC025457
      Consensus CDS
      CCDS3945.1
      UniProtKB/Swiss-Prot
      B2RDA6, Q0VDI3, Q9H6Z2
      UniProtKB/TrEMBL
      D6RAV6

    6. NM_001377399.1 → NP_001364328.1  transmembrane protein 267

      Status: VALIDATED

      Source sequence(s)
      AC025457
      Consensus CDS
      CCDS3945.1
      UniProtKB/Swiss-Prot
      B2RDA6, Q0VDI3, Q9H6Z2
      UniProtKB/TrEMBL
      D6RAV6

    7. NM_001377400.1 → NP_001364329.1  transmembrane protein 267

      Status: VALIDATED

      Source sequence(s)
      AC025457
      Consensus CDS
      CCDS3945.1
      UniProtKB/Swiss-Prot
      B2RDA6, Q0VDI3, Q9H6Z2
      UniProtKB/TrEMBL
      D6RAV6

    8. NM_001377401.1 → NP_001364330.1  transmembrane protein 267

      Status: VALIDATED

      Source sequence(s)
      AC025457
      Consensus CDS
      CCDS3945.1
      UniProtKB/Swiss-Prot
      B2RDA6, Q0VDI3, Q9H6Z2
      UniProtKB/TrEMBL
      D6RAV6
      Related
      ENSP00000424720.1, ENST00000506860.1

    9. NM_001377402.1 → NP_001364331.1  transmembrane protein 267

      Status: VALIDATED

      Source sequence(s)
      AC025457
      Consensus CDS
      CCDS3945.1
      UniProtKB/Swiss-Prot
      B2RDA6, Q0VDI3, Q9H6Z2
      UniProtKB/TrEMBL
      D6RAV6

    10. NM_001377403.1 → NP_001364332.1  transmembrane protein 267

      Status: VALIDATED

      Source sequence(s)
      AC025457
      Consensus CDS
      CCDS3945.1
      UniProtKB/Swiss-Prot
      B2RDA6, Q0VDI3, Q9H6Z2
      UniProtKB/TrEMBL
      D6RAV6
      Related
      ENSP00000426067.1, ENST00000500337.6

    11. NM_022483.5 → NP_071928.2  transmembrane protein 267

      See identical proteins and their annotated locations for NP_071928.2

      Status: VALIDATED

      Source sequence(s)
      AC025457, DA028175, DA035926
      Consensus CDS
      CCDS3945.1
      UniProtKB/Swiss-Prot
      B2RDA6, Q0VDI3, Q9H6Z2
      UniProtKB/TrEMBL
      D6RAV6
      Related
      ENSP00000380270.3, ENST00000397080.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      43444252..43484387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417517.1 → XP_047273473.1  transmembrane protein 267 isoform X1

      UniProtKB/Swiss-Prot
      B2RDA6, Q0VDI3, Q9H6Z2
      UniProtKB/TrEMBL
      D6RAV6

    2. XM_011514075.4 → XP_011512377.1  transmembrane protein 267 isoform X1

      See identical proteins and their annotated locations for XP_011512377.1

      UniProtKB/Swiss-Prot
      B2RDA6, Q0VDI3, Q9H6Z2
      UniProtKB/TrEMBL
      D6RAV6

    3. XM_047417516.1 → XP_047273472.1  transmembrane protein 267 isoform X1

      UniProtKB/Swiss-Prot
      B2RDA6, Q0VDI3, Q9H6Z2
      UniProtKB/TrEMBL
      D6RAV6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      43697085..43737220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353126.1 → XP_054209101.1  transmembrane protein 267 isoform X1

      UniProtKB/Swiss-Prot
      B2RDA6, Q0VDI3, Q9H6Z2
      UniProtKB/TrEMBL
      D6RAV6

    2. XM_054353125.1 → XP_054209100.1  transmembrane protein 267 isoform X1

      UniProtKB/Swiss-Prot
      B2RDA6, Q0VDI3, Q9H6Z2
      UniProtKB/TrEMBL
      D6RAV6

    3. XM_054353124.1 → XP_054209099.1  transmembrane protein 267 isoform X1

      UniProtKB/Swiss-Prot
      B2RDA6, Q0VDI3, Q9H6Z2
      UniProtKB/TrEMBL
      D6RAV6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VDI3.1 GenPept UniProtKB/Swiss-Prot:Q0VDI3

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