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    STAT2 signal transducer and activator of transcription 2 [ Homo sapiens (human) ]

    Gene ID: 6773, updated on 10-Dec-2024

    Summary

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    Official Symbol
    STAT2provided by HGNC
    Official Full Name
    signal transducer and activator of transcription 2provided by HGNC
    Primary source
    HGNC:HGNC:11363
    See related
    Ensembl:ENSG00000170581 MIM:600556; AllianceGenome:HGNC:11363
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P113; IMD44; ISGF-3; PTORCH3; STAT113
    Summary
    The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44. [provided by RefSeq, Aug 2020]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Ubiquitous expression in spleen (RPKM 31.9), appendix (RPKM 25.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STAT2 in Genome Data Viewer
    Location:
    12q13.3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56341597..56360107, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56309243..56327794, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56735381..56753891, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak1742 silencer Neighboring gene poly(A) specific ribonuclease subunit PAN2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6491 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:56730556-56731403 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:56731981-56733180 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29688 Neighboring gene interleukin 23 subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4558 Neighboring gene RNA, U7 small nuclear 40 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6495 Neighboring gene apolipoprotein F Neighboring gene apolipoprotein N, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Resistance to IFN-alpha-induced apoptosis is linked to a loss of STAT2. Romero-Weaver AL, et al. Mol Cancer Res, 2010 Jan. PMID 20068068, Free PMC Article
    2. Human Disease Phenotypes Associated with Loss and Gain of Function Mutations in STAT2: Viral Susceptibility and Type I Interferonopathy. Duncan CJA, et al. J Clin Immunol, 2021 Oct. PMID 34448086, Free PMC Article
    3. Life-Threatening Influenza, Hemophagocytic Lymphohistiocytosis and Probable Vaccine-Strain Varicella in a Novel Case of Homozygous STAT2 Deficiency. Freij BJ, et al. Front Immunol, 2020. PMID 33679716, Free PMC Article
    4. [High expression of STAT2 in ovarian cancer and its effect on metastasis of ovarian cancer cells]. Chen X, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2020 Jan 30. PMID 32376554, Free PMC Article
    5. Porcine circovirus 3 Cap inhibits type I interferon signaling through interaction with STAT2. Shen H, et al. Virus Res, 2020 Jan 2. PMID 31697988

    See all (234) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. African swine fever virus pB475L evades host antiviral innate immunity via targeting STAT2 to inhibit IFN-I signaling.
      Title: African swine fever virus pB475L evades host antiviral innate immunity via targeting STAT2 to inhibit IFN-I signaling.
    2. The lack of either IRF9, or STAT2, has surprisingly little effect on human natural killer cell development and function.
      Title: The lack of either IRF9, or STAT2, has surprisingly little effect on human natural killer cell development and function.
    3. ISGF3 and STAT2/IRF9 Control Basal and IFN-Induced Transcription through Genome-Wide Binding of Phosphorylated and Unphosphorylated Complexes to Common ISRE-Containing ISGs.
      Title: ISGF3 and STAT2/IRF9 Control Basal and IFN-Induced Transcription through Genome-Wide Binding of Phosphorylated and Unphosphorylated Complexes to Common ISRE-Containing ISGs.
    4. Investigation of the impact of AXL, TLR3, and STAT2 in congenital Zika syndrome through genetic polymorphisms and protein-protein interaction network analyses.
      Title: Investigation of the impact of AXL, TLR3, and STAT2 in congenital Zika syndrome through genetic polymorphisms and protein-protein interaction network analyses.
    5. Human inherited complete STAT2 deficiency underlies inflammatory viral diseases.
      Title: Human inherited complete STAT2 deficiency underlies inflammatory viral diseases.
    6. STAT2 act a prognostic biomarker and associated with immune infiltration in kidney renal clear cell carcinoma.
      Title: STAT2 act a prognostic biomarker and associated with immune infiltration in kidney renal clear cell carcinoma.
    7. circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer.
      Title: circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer.
    8. Aberrant inflammatory responses to type I interferon in STAT2 or IRF9 deficiency.
      Title: Aberrant inflammatory responses to type I interferon in STAT2 or IRF9 deficiency.
    9. Exposing the Two Contrasting Faces of STAT2 in Inflammation.
      Title: Exposing the Two Contrasting Faces of STAT2 in Inflammation.
    10. Initial activation of STAT2 induced by IAV infection is critical for innate antiviral immunity.
      Title: Initial activation of STAT2 induced by IAV infection is critical for innate antiviral immunity.
    Submit: New GeneRIF Correction See all GeneRIFs (123)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection
    MedGen: C4225260 OMIM: 616636 GeneReviews: Not available
    		not available
    Pseudo-TORCH syndrome 3
    MedGen: C5394391 OMIM: 618886 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.
    EBI GWAS Catalog
    Genome-wide association study in Han Chinese identifies three novel loci for human height.
    EBI GWAS Catalog
    Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog
    Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 activates both STAT1 and STAT2 in primary human monocyte-derived dendritic cells PubMed
    Nef nef TRAF2 and TRAF6 proteins are required for the HIV-1 Nef-induced tyrosine phosphorylation of STAT1 and STAT2 proteins. Both myristoylation and acidic cluster of Nef are essential to induce the tyrosine phosphorylation PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC59816

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-like protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of type I interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to peptide hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in type I interferon-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ISGF3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ISGF3 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of RNA polymerase II transcription regulator complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in chromatin IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    signal transducer and activator of transcription 2
    Names
    interferon alpha induced transcriptional activator
    signal transducer and activator of transcription 2, 113kDa

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046314.1 RefSeqGene

      Range
      5147..23657
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1329

    mRNA and Protein(s)

    1. NM_001385110.1 → NP_001372039.1  signal transducer and activator of transcription 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC025574
      UniProtKB/TrEMBL
      R9QDW3, R9QDW5, R9QDY3, R9QE44, R9QE53, R9QE71, R9QFA6, R9QGC0
      Conserved Domains (5) summary
      cd10373
      Location:545 → 695
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 120
      STAT_int; STAT protein, protein interaction domain
      cd16852
      Location:137 → 308
      STAT2_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28920
      Location:312 → 464
      STAT_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
      pfam12188
      Location:775 → 827
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    2. NM_001385111.1 → NP_001372040.1  signal transducer and activator of transcription 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC025574
      Consensus CDS
      CCDS91707.1
      UniProtKB/TrEMBL
      A0A494C164, R9QE44, R9QFA6
      Related
      ENSP00000498876.1, ENST00000651915.1
      Conserved Domains (5) summary
      cd10373
      Location:523 → 673
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16852
      Location:141 → 312
      STAT2_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28920
      Location:316 → 446
      STAT_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
      pfam12188
      Location:753 → 805
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    3. NM_001385113.1 → NP_001372042.1  signal transducer and activator of transcription 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC025574
      UniProtKB/TrEMBL
      A0A8V8TLJ4
      Related
      ENSP00000513600.1, ENST00000698193.1
      Conserved Domains (5) summary
      cd10373
      Location:556 → 706
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16852
      Location:141 → 312
      STAT2_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28920
      Location:316 → 475
      STAT_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
      pfam12188
      Location:786 → 805
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    4. NM_001385114.1 → NP_001372043.1  signal transducer and activator of transcription 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC025574
      UniProtKB/TrEMBL
      R9QDW3, R9QDW5, R9QDY3, R9QE44, R9QE53, R9QE71, R9QFA6, R9QGC0
      Related
      ENST00000698187.1
      Conserved Domains (5) summary
      cd10373
      Location:549 → 699
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16852
      Location:141 → 312
      STAT2_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28920
      Location:316 → 468
      STAT_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
      pfam12188
      Location:779 → 831
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    5. NM_001385115.1 → NP_001372044.1  signal transducer and activator of transcription 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC025574
      UniProtKB/TrEMBL
      R9QDW3, R9QDW5, R9QDY3, R9QE44, R9QE53, R9QE71, R9QFA6, R9QGC0
      Conserved Domains (5) summary
      cd10373
      Location:542 → 692
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 120
      STAT_int; STAT protein, protein interaction domain
      cd16852
      Location:137 → 308
      STAT2_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28920
      Location:312 → 471
      STAT_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
      pfam12188
      Location:772 → 824
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    6. NM_005419.4 → NP_005410.1  signal transducer and activator of transcription 2 isoform 1

      See identical proteins and their annotated locations for NP_005410.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC051284, DB482283
      Consensus CDS
      CCDS8917.1
      UniProtKB/Swiss-Prot
      B4DLC7, G3V2M6, P52630, Q16430, Q16431, Q9UDL4
      UniProtKB/TrEMBL
      R9QDW3, R9QDW5, R9QDY3, R9QE44, R9QE53, R9QE65, R9QE71, R9QFA6, R9QGC0
      Related
      ENSP00000315768.4, ENST00000314128.9
      Conserved Domains (5) summary
      cd10373
      Location:556 → 706
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16852
      Location:141 → 312
      STAT2_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28920
      Location:316 → 475
      STAT_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
      pfam12188
      Location:786 → 838
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    7. NM_198332.2 → NP_938146.1  signal transducer and activator of transcription 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The resulting isoform (2) lacks an internal 4-aa segment, compared to isoform 1.
      Source sequence(s)
      AK296939, BC051284
      Consensus CDS
      CCDS55836.1
      UniProtKB/TrEMBL
      R9QDW3, R9QDW5, R9QDY3, R9QE44, R9QE53, R9QE71, R9QFA6, R9QGC0
      Related
      ENSP00000450751.1, ENST00000557235.5
      Conserved Domains (5) summary
      cd10373
      Location:552 → 702
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 120
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:138 → 310
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:312 → 561
      STAT_bind; STAT protein, DNA binding domain
      pfam12188
      Location:779 → 834
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      56341597..56360107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538698.4 → XP_011537000.1  signal transducer and activator of transcription 2 isoform X2

      UniProtKB/TrEMBL
      R9QDW3, R9QDW5, R9QDY3, R9QE44, R9QE53, R9QE71, R9QFA6, R9QGC0
      Conserved Domains (5) summary
      cd10373
      Location:560 → 710
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 120
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:138 → 310
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:312 → 569
      STAT_bind; STAT protein, DNA binding domain
      pfam12188
      Location:787 → 842
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    2. XM_011538697.3 → XP_011536999.1  signal transducer and activator of transcription 2 isoform X1

      UniProtKB/TrEMBL
      R9QDW3, R9QDW5, R9QDY3, R9QE44, R9QE53, R9QE71, R9QFA6, R9QGC0
      Conserved Domains (5) summary
      cd10373
      Location:564 → 714
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      cd16852
      Location:141 → 312
      STAT2_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 2 (STAT2)
      cl28920
      Location:316 → 475
      STAT_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)
      pfam12188
      Location:794 → 846
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    3. XM_047429469.1 → XP_047285425.1  signal transducer and activator of transcription 2 isoform X5

      UniProtKB/TrEMBL
      Q6N0A7
      Related
      ENST00000556539.5

    4. XM_011538699.4 → XP_011537001.1  signal transducer and activator of transcription 2 isoform X3

      UniProtKB/TrEMBL
      A0JLQ9
      Conserved Domains (4) summary
      smart00964
      Location:2 → 124
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:142 → 314
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:316 → 573
      STAT_bind; STAT protein, DNA binding domain
      cl15255
      Location:564 → 584
      SH2; Src homology 2 (SH2) domain

    5. XM_047429468.1 → XP_047285424.1  signal transducer and activator of transcription 2 isoform X4

      UniProtKB/TrEMBL
      A0JLQ9

    6. XM_047429470.1 → XP_047285426.1  signal transducer and activator of transcription 2 isoform X6

      UniProtKB/TrEMBL
      B4DLC8

    7. XM_047429471.1 → XP_047285427.1  signal transducer and activator of transcription 2 isoform X7

      UniProtKB/TrEMBL
      B4DLC8
      Related
      ENSP00000387354.2, ENST00000418572.7

    8. XM_047429472.1 → XP_047285428.1  signal transducer and activator of transcription 2 isoform X7

      UniProtKB/TrEMBL
      B4DLC8

    RNA

    1. XR_007063122.1 RNA Sequence

    2. XR_245953.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      56309243..56327794 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373086.1 → XP_054229061.1  signal transducer and activator of transcription 2 isoform X2

      UniProtKB/TrEMBL
      R9QDW3, R9QDW5, R9QDY3, R9QE44, R9QE53, R9QE71, R9QFA6, R9QGC0

    2. XM_054373085.1 → XP_054229060.1  signal transducer and activator of transcription 2 isoform X1

      UniProtKB/TrEMBL
      R9QDW3, R9QDW5, R9QDY3, R9QE44, R9QE53, R9QE71, R9QFA6, R9QGC0

    3. XM_054373089.1 → XP_054229064.1  signal transducer and activator of transcription 2 isoform X5

      UniProtKB/TrEMBL
      Q6N0A7

    4. XM_054373087.1 → XP_054229062.1  signal transducer and activator of transcription 2 isoform X3

      UniProtKB/TrEMBL
      A0JLQ9

    5. XM_054373088.1 → XP_054229063.1  signal transducer and activator of transcription 2 isoform X4

      UniProtKB/TrEMBL
      A0JLQ9

    6. XM_054373090.1 → XP_054229065.1  signal transducer and activator of transcription 2 isoform X6

      UniProtKB/TrEMBL
      B4DLC8

    7. XM_054373091.1 → XP_054229066.1  signal transducer and activator of transcription 2 isoform X7

      UniProtKB/TrEMBL
      B4DLC8

    8. XM_054373092.1 → XP_054229067.1  signal transducer and activator of transcription 2 isoform X7

      UniProtKB/TrEMBL
      B4DLC8

    RNA

    1. XR_008488674.1 RNA Sequence

    2. XR_008488673.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52630.1 GenPept UniProtKB/Swiss-Prot:P52630

    Gene LinkOut

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