NPY1R neuropeptide Y receptor Y1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NPY1Rprovided by HGNC
Official Full Name: neuropeptide Y receptor Y1provided by HGNC
Primary source: HGNC:HGNC:7956
See related: Ensembl:ENSG00000164128 MIM:162641; AllianceGenome:HGNC:7956
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NPYR; NPY1-R
Summary: This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
Expression: Biased expression in spleen (RPKM 33.6), fat (RPKM 10.5) and 9 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q32.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (163323962..163344689, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (166671793..166692717, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (164245114..164253748, complement)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Integrative Analysis of Exosomal miR-452 and miR-4713 Downregulating NPY1R for the Prevention of Childhood Obesity.
Title: Integrative Analysis of Exosomal miR-452 and miR-4713 Downregulating NPY1R for the Prevention of Childhood Obesity.
Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation.
Title: Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation.
NPY1R exerts inhibitory action on estradiol-stimulated growth and predicts endocrine sensitivity and better survival in ER-positive breast cancer.
Title: NPY1R exerts inhibitory action on estradiol-stimulated growth and predicts endocrine sensitivity and better survival in ER-positive breast cancer.
Structural basis of neuropeptide Y signaling through Y1 receptor.
Title: Structural basis of neuropeptide Y signaling through Y1 receptor.
Theoretical study of the interactions between peptide tyrosine tyrosine [PYY (1-36)], a newly identified modulator in type 2 diabetes pathophysiology, with receptors NPY1R and NPY4R.
Title: Theoretical study of the interactions between peptide tyrosine tyrosine [PYY (1-36)], a newly identified modulator in type 2 diabetes pathophysiology, with receptors NPY1R and NPY4R.
Differential regulation of NPY and SP receptor expression in STRO-1+ve PDLSCs by inflammatory cytokines.
Title: Differential regulation of NPY and SP receptor expression in STRO-1+ve PDLSCs by inflammatory cytokines.
Clinical Significance of Immunohistochemical Expression of Neuropeptide Y1 Receptor in Patients With Breast Cancer in Egypt.
Title: Clinical Significance of Immunohistochemical Expression of Neuropeptide Y1 Receptor in Patients With Breast Cancer in Egypt.
Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence.
Title: Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence.
Strategic Aspects of NPY-Based Monoclonal Antibodies for Diagnosis and Treatment of Breast Cancer.
Title: Strategic Aspects of NPY-Based Monoclonal Antibodies for Diagnosis and Treatment of Breast Cancer.
the current review aims to compile, evaluate and summarise current knowledge on PYY, with particular emphasis on obesity and diabetes treatment, and the importance of specific Y receptor interactions for this.
Title: Emerging therapeutic potential for peptide YY for obesity-diabetes.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NPY1R_956 (e-PCR)
- UniSTS:280867

NPY1R_V234 (e-PCR)
- UniSTS:280867

NPY1R (e-PCR)
- UniSTS:479876

SHGC-12458 (e-PCR)
- UniSTS:3241

SHGC-59526 (e-PCR)
- UniSTS:40658

SHGC-67951 (e-PCR)
- UniSTS:43764

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables neuropeptide Y receptor activity	TAS Traceable Author Statement more info	PubMed
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables pancreatic polypeptide receptor activity	IEA Inferred from Electronic Annotation more info
enables peptide YY receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in feeding behavior	IEA Inferred from Electronic Annotation more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in locomotory behavior	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in outflow tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of blood pressure	IEA Inferred from Electronic Annotation more info
involved_in regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of pain	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: neuropeptide Y receptor type 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000909.6 → NP_000900.1 neuropeptide Y receptor type 1

See identical proteins and their annotated locations for NP_000900.1

Status: VALIDATED

Source sequence(s)

AC079238, BC036657

Consensus CDS

CCDS34089.1

UniProtKB/Swiss-Prot

B2R6H5, P25929

Related

ENSP00000354652.2, ENST00000296533.3

Conserved Domains (2) summary

pfam00001
Location:57 → 320

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:52 → 176

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

163323962..163344689 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005263031.5 → XP_005263088.1 neuropeptide Y receptor type 1 isoform X1

See identical proteins and their annotated locations for XP_005263088.1

UniProtKB/Swiss-Prot

B2R6H5, P25929

Conserved Domains (2) summary

pfam00001
Location:57 → 320

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:52 → 176

7tm_4; Olfactory receptor
XM_011532010.4 → XP_011530312.1 neuropeptide Y receptor type 1 isoform X1

See identical proteins and their annotated locations for XP_011530312.1

UniProtKB/Swiss-Prot

B2R6H5, P25929

Conserved Domains (2) summary

pfam00001
Location:57 → 320

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:52 → 176

7tm_4; Olfactory receptor

Alternate T2T-CHM13v2.0

Genomic

NC_060928.1 Alternate T2T-CHM13v2.0

Range

166671793..166692717 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054350119.1 → XP_054206094.1 neuropeptide Y receptor type 1 isoform X1

UniProtKB/Swiss-Prot

B2R6H5, P25929
XM_054350120.1 → XP_054206095.1 neuropeptide Y receptor type 1 isoform X1

UniProtKB/Swiss-Prot

B2R6H5, P25929