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    HTR7 5-hydroxytryptamine receptor 7 [ Homo sapiens (human) ]

    Gene ID: 3363, updated on 10-Dec-2024

    Summary

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    Official Symbol
    HTR7provided by HGNC
    Official Full Name
    5-hydroxytryptamine receptor 7provided by HGNC
    Primary source
    HGNC:HGNC:5302
    See related
    Ensembl:ENSG00000148680 MIM:182137; AllianceGenome:HGNC:5302
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    5-HT7
    Summary
    The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 6.1), urinary bladder (RPKM 2.0) and 8 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HTR7 in Genome Data Viewer
    Location:
    10q23.31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (90740823..90858039, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (91624488..91741713, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (92500580..92617796, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2653 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:92243978-92245177 Neighboring gene uncharacterized LOC124902478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3755 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:92564844-92565562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2600 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2601 Neighboring gene Sharpr-MPRA regulatory region 7939 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3757 Neighboring gene ribonuclease P/MRP subunit p30 Neighboring gene ankyrin repeat domain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Positive association of the serotonin 5-HT7 receptor gene with schizophrenia in a Japanese population. Ikeda M, et al. Neuropsychopharmacology, 2006 Apr. PMID 16192982
    2. [Possible involvement of 5-HT₇ receptor in pathophysiology of affective disorders and action of antidepressant drugs]. Tokarski K, et al. Postepy Hig Med Dosw (Online), 2014 Sep 12. PMID 25228519
    3. Association between HTR7 genetic polymorphisms and alcohol dependence, using the alcohol use disorders identification test (AUDIT). Kim JH, et al. Alcohol Clin Exp Res, 2014 Sep. PMID 25070732
    4. Role of the 5-HT7 receptor in the central nervous system: from current status to future perspectives. Matthys A, et al. Mol Neurobiol, 2011 Jun. PMID 21424680
    5. Clozapine and other competitive antagonists reactivate risperidone-inactivated h5-HT7 receptors: radioligand binding and functional evidence for GPCR homodimer protomer interactions. Teitler M, et al. Psychopharmacology (Berl), 2010 Dec. PMID 20827463, Free PMC Article

    See all (73) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Serotonin 5-HT7 receptor is a biomarker poor prognostic factor and induces proliferation of triple-negative breast cancer cells through FOXM1.
      Title: Serotonin 5-HT7 receptor is a biomarker poor prognostic factor and induces proliferation of triple-negative breast cancer cells through FOXM1.
    2. 5-HT7 receptors in Alzheimer's disease.
      Title: 5-HT(7) receptors in Alzheimer's disease.
    3. 5-HT7 receptors as a new target for prostate cancer physiopathology and treatment: an experimental study on PC-3 cells and FFPE tissues.
      Title: 5-HT7 receptors as a new target for prostate cancer physiopathology and treatment: an experimental study on PC-3 cells and FFPE tissues.
    4. Effects of 5-HT7 receptors on circadian rhythm of mice anesthetized with isoflurane.
      Title: Effects of 5-HT7 receptors on circadian rhythm of mice anesthetized with isoflurane.
    5. Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease.
      Title: Role of the Serotonin Receptor 7 in Brain Plasticity: From Development to Disease.
    6. Stimulating DDX3 expression by serotonin 5-HT receptor 7 through phosphorylation of p53 via the AC-PKA-ERK signaling pathway.
      Title: Stimulating DDX3 expression by serotonin 5-HT receptor 7 through phosphorylation of p53 via the AC-PKA-ERK signaling pathway.
    7. 5-HT7 receptors are widely expressed in a vast repertoire of immune and non-immune cells. The receptor has diverse -and even discrepant- roles in the immune response. [review]
      Title: Role of 5-HT(7) receptors in the immune system in health and disease.
    8. MiRNA-29a is upregulated in and HTR7 is downregulated in irritable bowel syndrome (IBS). HTR7 is a direct target of miRNA-29a. MiRNA-29a plays a role in visceral hyperalgesia pathogenesis of IBS.
      Title: MiRNA-29a modulates visceral hyperalgesia in irritable bowel syndrome by targeting HTR7.
    9. the impact of template choice, alignment, and model building methods on the homology model of 5-HT7R is addressed.
      Title: Improvising 5-HT(7)R homology model for design of high affinity ligands: model validation with docking, embrace minimization, MM-GBSA, and molecular dynamic simulations.
    10. zinc can act as a negative allosteric inhibitor of 5-HT7 receptors.
      Title: Allosteric Inhibition of Serotonin 5-HT(7) Receptors by Zinc Ions.
    Submit: New GeneRIF Correction See all GeneRIFs (43)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variants and gene expression associated with white matter microstructure in the human brain.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serotonin receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-activating serotonin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in blood circulation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    5-hydroxytryptamine receptor 7
    Names
    5-HT-7
    5-HT-X
    5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029218.1 RefSeqGene

      Range
      4876..122092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000872.5 → NP_000863.1  5-hydroxytryptamine receptor 7 isoform a

      See identical proteins and their annotated locations for NP_000863.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (a) results from the alternative usage of the first of two tandemly arranged splice donor sites at the 5' end of intron 2, which causes the protein to have a 13 amino acid longer carboxy tail relative to isoform b.
      Source sequence(s)
      AL360011, BC047526, BG108256
      Consensus CDS
      CCDS7409.1
      UniProtKB/Swiss-Prot
      P34969
      Related
      ENSP00000277874.6, ENST00000277874.10
      Conserved Domains (1) summary
      cd15329
      Location:97 → 395
      7tmA_5-HT7; serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_019859.4 → NP_062873.1  5-hydroxytryptamine receptor 7 isoform d

      See identical proteins and their annotated locations for NP_062873.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (d) results from the inclusion of a 98 base pair exon cassette (exon D) at the exon II/exon III boundary, as compared to splice variant a. The inclusion of exon D results in a protein with a carboxy terminal end 34 amino acids longer than the splice variant a protein.
      Source sequence(s)
      AL360011, BC047526, BG108256, U68488
      Consensus CDS
      CCDS7408.1
      UniProtKB/Swiss-Prot
      B5BUP6, P34969, P78336, P78372, P78516, Q5VX01, Q5VX02, Q5VX03
      Related
      ENSP00000337949.3, ENST00000336152.8
      Conserved Domains (2) summary
      pfam00001
      Location:98 → 384
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:98 → 215
      7tm_4; Olfactory receptor

    3. NM_019860.4 → NP_062874.1  5-hydroxytryptamine receptor 7 isoform b

      See identical proteins and their annotated locations for NP_062874.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (b) results from the alternative usage of the second of the two tandemly arranged splice donor sites at the 5' end of intron 2, which causes an in-frame stop codon and shortens the protein's carboxy tail by 13 amino acids relative to isoform a.
      Source sequence(s)
      AL360011, BC047526, BG108256, U68487
      Consensus CDS
      CCDS7410.1
      UniProtKB/Swiss-Prot
      P34969
      Related
      ENSP00000360784.2, ENST00000371719.2
      Conserved Domains (1) summary
      cd15329
      Location:97 → 395
      7tmA_5-HT7; serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      90740823..90858039 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447973.2 → XP_024303741.1  5-hydroxytryptamine receptor 7 isoform X1

      Conserved Domains (2) summary
      cd15329
      Location:3 → 19
      7tmA_5-HT7; TM helix 4 [structural motif]
      cl28897
      Location:1 → 197
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      91624488..91741713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365712.1 → XP_054221687.1  5-hydroxytryptamine receptor 7 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34969.2 GenPept UniProtKB/Swiss-Prot:P34969

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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