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    ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 [ Homo sapiens (human) ]

    Gene ID: 10402, updated on 14-Dec-2024

    Summary

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    Official Symbol
    ST3GAL6provided by HGNC
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 6provided by HGNC
    Primary source
    HGNC:HGNC:18080
    See related
    Ensembl:ENSG00000064225 MIM:607156; AllianceGenome:HGNC:18080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIAT10; ST3GALVI
    Summary
    The protein encoded by this gene is a member of the sialyltransferase family. Members of this family are enzymes that transfer sialic acid from the activated cytidine 5'-monophospho-N-acetylneuraminic acid to terminal positions on sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. This protein has high specificity for neolactotetraosylceramide and neolactohexaosylceramide as glycolipid substrates and may contribute to the formation of selectin ligands and sialyl Lewis X, a carbohydrate important for cell-to-cell recognition and a blood group antigen. [provided by RefSeq, Apr 2016]
    Expression
    Broad expression in heart (RPKM 8.2), liver (RPKM 7.6) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ST3GAL6 in Genome Data Viewer
    Location:
    3q12.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (98732262..98795852)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (101440560..101504133)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (98451106..98514696)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L19 pseudogene 7 Neighboring gene Sharpr-MPRA regulatory region 220 Neighboring gene WW domain containing E3 ubiquitin protein ligase 1 pseudogene 1 Neighboring gene ST3GAL6 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:98450961-98451709 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:98451710-98452457 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14561 Neighboring gene PDZ and LIM domain 1 pseudogene 4 Neighboring gene discoidin, CUB and LCCL domain containing 2 Neighboring gene RNA, U6 small nuclear 26, pseudogene Neighboring gene uncharacterized LOC124906384

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Gene structure and transcriptional regulation of human Gal beta1,4(3) GlcNAc alpha2,3-sialyltransferase VI (hST3Gal VI) gene in prostate cancer cell line. Taniguchi A, et al. Biochem Biophys Res Commun, 2001 Oct 12. PMID 11587543
    2. N-glycan structures and associated gene expression reflect the characteristic N-glycosylation pattern of human hematopoietic stem and progenitor cells. Hemmoranta H, et al. Exp Hematol, 2007 Aug. PMID 17662891
    3. A functional analysis of N-glycosylation-related genes on sialylation of recombinant erythropoietin in six commonly used mammalian cell lines. Zhang P, et al. Metab Eng, 2010 Nov. PMID 20826224
    4. The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma. Glavey SV, et al. Blood, 2014 Sep 11. PMID 25061176, Free PMC Article
    5. A fine-mapping study of 7 top scoring genes from a GWAS for major depressive disorder. Verbeek EC, et al. PLoS One, 2012. PMID 22649524, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. lncRNA ST3GAL6AS1 promotes invasion by inhibiting hnRNPA2B1mediated ST3GAL6 expression in multiple myeloma.
      Title: lncRNA ST3GAL6‑AS1 promotes invasion by inhibiting hnRNPA2B1‑mediated ST3GAL6 expression in multiple myeloma.
    2. a cross-restoration of each of the three genes in ST3GAL6 KO cells showed that overexpression of ST3GAL6 sufficiently rescued the total alpha2,3-sialylation levels, cell morphology, and alpha2,3-sialylation of EGFR, whereas the alpha2,3-sialylation levels of beta1 were greatly enhanced by an overexpression of ST3GAL4
      Title: ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the α2,3-sialylation of target proteins.
    3. The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma.
      Title: The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma.
    4. the occurrence of CD75s- and iso-CD75s-gangliosides in tumor tissues is largely independent of the transcriptional expression of ST6GAL1 and ST3GAL6
      Title: Differences in CD75s- and iso-CD75s-ganglioside content and altered mRNA expression of sialyltransferases ST6GAL1 and ST3GAL6 in human hepatocellular carcinomas and nontumoral liver tissues.
    5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes.
    6. Expression of ST3Gal IV in several gastrointestinal cell lines is correlated with the expression of sialyl Lewis x at the cell surface.
      Title: Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells.
    7. Epigenetic changes in a group of glycosyltransferases including B4GALNT2 and ST3GAL6 represent a malignant phenotype of gastric cancer caused by silencing of the activity of these enzymes
      Title: DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables N-acetyllactosaminide alpha-2,3-sialyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables sialyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to interleukin-6 IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in glycolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in keratan sulfate biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in oligosaccharide biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type 2 lactosamine alpha-2,3-sialyltransferase
    Names
    CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
    alpha2,3-sialyltransferase ST3Gal VI
    sialyltransferase 10 (alpha-2,3-sialyltransferase VI)
    NP_001258071.1
    NP_001258074.1
    NP_001258075.1
    NP_001258076.1
    NP_001258077.1
    NP_001310281.1
    NP_001310282.1
    NP_001310287.1
    NP_001310288.1
    NP_001310289.1
    NP_001310291.1
    NP_001310292.1
    NP_001310293.1
    NP_001310294.1
    NP_001310295.1
    NP_001310296.2
    NP_001310297.1
    NP_006091.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271142.2 → NP_001258071.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 2

      See identical proteins and their annotated locations for NP_001258071.1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 2, 10 and 11 encode the same isoform (2).
      Source sequence(s)
      AC106728, BC001266, DB036799
      Conserved Domains (1) summary
      pfam00777
      Location:23 → 238
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. NM_001271145.2 → NP_001258074.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 3

      See identical proteins and their annotated locations for NP_001258074.1

      Status: REVIEWED

      Source sequence(s)
      AC106728, AF119391, CB960395
      UniProtKB/TrEMBL
      A0A087WXB8
      Conserved Domains (1) summary
      pfam00777
      Location:161 → 383
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. NM_001271146.2 → NP_001258075.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

      See identical proteins and their annotated locations for NP_001258075.1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1, 4, 7, 8 and 9 encode the same isoform (1).
      Source sequence(s)
      AB022918, AC106728, DB036799
      Consensus CDS
      CCDS2933.1
      UniProtKB/Swiss-Prot
      B2RCH2, B3KMI1, D3DN39, F8W6U0, Q9Y274
      Related
      ENSP00000265261.7, ENST00000265261.11
      Conserved Domains (1) summary
      pfam00777
      Location:85 → 329
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. NM_001271147.2 → NP_001258076.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 4

      See identical proteins and their annotated locations for NP_001258076.1

      Status: REVIEWED

      Source sequence(s)
      AC106728, AK001922, BC001266, HY123342
      UniProtKB/Swiss-Prot
      Q9Y274
      Conserved Domains (1) summary
      pfam00777
      Location:22 → 211
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    5. NM_001271148.2 → NP_001258077.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 5

      See identical proteins and their annotated locations for NP_001258077.1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 6, 12, 13, 14 and 15 encode the same isoform (5).
      Source sequence(s)
      AC106728, AL539506, BC001266, HY123342
      Conserved Domains (1) summary
      pfam00777
      Location:1 → 185
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    6. NM_001323352.2 → NP_001310281.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1, 4, 7, 8 and 9 encode the same isoform (1).
      Source sequence(s)
      AC106728
      Consensus CDS
      CCDS2933.1
      UniProtKB/Swiss-Prot
      B2RCH2, B3KMI1, D3DN39, F8W6U0, Q9Y274
      Conserved Domains (1) summary
      pfam00777
      Location:85 → 329
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    7. NM_001323353.2 → NP_001310282.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: Variants 6, 12, 13, 14 and 15 encode the same isoform (5).
      Source sequence(s)
      AC106728
      Conserved Domains (1) summary
      pfam00777
      Location:1 → 185
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    8. NM_001323358.2 → NP_001310287.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: Variants 17 and 18 encode the same isoform (7).
      Source sequence(s)
      AC106728

    9. NM_001323359.2 → NP_001310288.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: Variants 17 and 18 encode the same isoform (7).
      Source sequence(s)
      AC106728

    10. NM_001323360.2 → NP_001310289.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: Variants 2, 10 and 11 encode the same isoform (2).
      Source sequence(s)
      AC106728
      Conserved Domains (1) summary
      pfam00777
      Location:23 → 238
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    11. NM_001323362.2 → NP_001310291.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: Variants 6, 12, 13, 14 and 15 encode the same isoform (5).
      Source sequence(s)
      AC106728
      Conserved Domains (1) summary
      pfam00777
      Location:1 → 185
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    12. NM_001323363.2 → NP_001310292.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: Variants 6, 12, 13, 14 and 15 encode the same isoform (5).
      Source sequence(s)
      AC106728
      Conserved Domains (1) summary
      pfam00777
      Location:1 → 185
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    13. NM_001323364.2 → NP_001310293.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: Variants 6, 12, 13, 14 and 15 encode the same isoform (5).
      Source sequence(s)
      AC106728
      Conserved Domains (1) summary
      pfam00777
      Location:1 → 185
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    14. NM_001323365.2 → NP_001310294.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1, 4, 7, 8 and 9 encode the same isoform (1).
      Source sequence(s)
      AC106728
      Consensus CDS
      CCDS2933.1
      UniProtKB/Swiss-Prot
      B2RCH2, B3KMI1, D3DN39, F8W6U0, Q9Y274
      Conserved Domains (1) summary
      pfam00777
      Location:85 → 329
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    15. NM_001323366.2 → NP_001310295.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: Variants 2, 10 and 11 encode the same isoform (2).
      Source sequence(s)
      AC106728
      Conserved Domains (1) summary
      pfam00777
      Location:23 → 238
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    16. NM_001323367.4 → NP_001310296.2  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC106728
      Consensus CDS
      CCDS2933.1
      UniProtKB/Swiss-Prot
      B2RCH2, B3KMI1, D3DN39, F8W6U0, Q9Y274
      Conserved Domains (1) summary
      pfam00777
      Location:85 → 329
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    17. NM_001323368.2 → NP_001310297.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1, 4, 7, 8 and 9 encode the same isoform (1).
      Source sequence(s)
      AC106728
      Consensus CDS
      CCDS2933.1
      UniProtKB/Swiss-Prot
      B2RCH2, B3KMI1, D3DN39, F8W6U0, Q9Y274
      Related
      ENSP00000417376.1, ENST00000483910.6
      Conserved Domains (1) summary
      pfam00777
      Location:85 → 329
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    18. NM_006100.4 → NP_006091.1  type 2 lactosamine alpha-2,3-sialyltransferase isoform 1

      See identical proteins and their annotated locations for NP_006091.1

      Status: REVIEWED

      Description
      Transcript Variant: Variants 1, 4, 7, 8 and 9 encode the same isoform (1).
      Source sequence(s)
      AC106728, AK315111, BC023312, CB960395
      Consensus CDS
      CCDS2933.1
      UniProtKB/Swiss-Prot
      B2RCH2, B3KMI1, D3DN39, F8W6U0, Q9Y274
      Related
      ENSP00000377717.1, ENST00000394162.5
      Conserved Domains (1) summary
      pfam00777
      Location:85 → 329
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      98732262..98795852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      101440560..101504133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y274.1 GenPept UniProtKB/Swiss-Prot:Q9Y274

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