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    WDR91 WD repeat domain 91 [ Homo sapiens (human) ]

    Gene ID: 29062, updated on 10-Dec-2024

    Summary

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    Official Symbol
    WDR91provided by HGNC
    Official Full Name
    WD repeat domain 91provided by HGNC
    Primary source
    HGNC:HGNC:24997
    See related
    Ensembl:ENSG00000105875 MIM:616303; AllianceGenome:HGNC:24997
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SORF1; SORF-1; HSPC049
    Summary
    Enables phosphatidylinositol 3-kinase inhibitor activity. Involved in early endosome to late endosome transport and regulation of protein catabolic process. Located in cytosol; early endosome membrane; and late endosome membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney (RPKM 8.1), placenta (RPKM 7.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See WDR91 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (135183839..135211526, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (136491701..136519383, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (134868591..134896278, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene AGBL carboxypeptidase 3 Neighboring gene cell cycle regulator of NHEJ Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26702 Neighboring gene RNF14 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26706 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18676 Neighboring gene transmembrane protein 140 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26711 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:134877948-134879147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26712 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134888580-134888794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18677 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:134893611-134894810 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18678 Neighboring gene microRNA 6509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26713 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:134935285-134935435 Neighboring gene uncharacterized LOC107984123 Neighboring gene stimulated by retinoic acid 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26714 Neighboring gene solute carrier family 23 member 4, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. WDR91 is a Rab7 effector required for neuronal development. Liu K, et al. J Cell Biol, 2017 Oct 2. PMID 28860274, Free PMC Article
    2. A Genetic Screen Identifies a Critical Role for the WDR81-WDR91 Complex in the Trafficking and Degradation of Tetherin. Rapiteanu R, et al. Traffic, 2016 Aug. PMID 27126989, Free PMC Article
    3. The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy. Liu X, et al. J Cell Biol, 2017 May 1. PMID 28404643, Free PMC Article
    4. Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion. Liu K, et al. J Cell Biol, 2016 Jan 18. PMID 26783301, Free PMC Article
    5. Novel Cul3 binding proteins function to remodel E3 ligase complexes. Wimuttisuk W, et al. BMC Cell Biol, 2014 Jul 10. PMID 25011449, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of WD repeat domain 91 (WDR91; HSPC049) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidylinositol 3-kinase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidylinositol 3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in early endosome to late endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in early endosome to late endosome transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WD repeat-containing protein 91

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362736.2 → NP_001349665.1  WD repeat-containing protein 91 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC009542, AC083862, BC017246
      UniProtKB/TrEMBL
      C9J1X0
      Conserved Domains (3) summary
      sd00039
      Location:505 → 576
      7WD40; WD40 repeat [structural motif]
      pfam12881
      Location:253 → 343
      NUT; NUT protein
      cl25539
      Location:407 → 758
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001362737.2 → NP_001349666.1  WD repeat-containing protein 91 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC009542, AC083862, BC017246, BG767291
      UniProtKB/TrEMBL
      C9J1X0
      Conserved Domains (3) summary
      sd00039
      Location:454 → 510
      7WD40; WD40 repeat [structural motif]
      pfam12881
      Location:253 → 343
      NUT; NUT protein
      cl25539
      Location:407 → 765
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001362738.2 → NP_001349667.1  WD repeat-containing protein 91 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC009542, AC083862, BC017246, DA634150
      Conserved Domains (3) summary
      sd00039
      Location:243 → 314
      7WD40; WD40 repeat [structural motif]
      pfam12881
      Location:9 → 100
      NUT; NUT protein
      cl25539
      Location:164 → 496
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_014149.4 → NP_054868.3  WD repeat-containing protein 91 isoform 3

      See identical proteins and their annotated locations for NP_054868.3

      Status: VALIDATED

      Source sequence(s)
      AC009542, AC083862, BC017246
      Consensus CDS
      CCDS34758.1
      UniProtKB/Swiss-Prot
      A4D1P6, A6NK54, C9JMI4, Q6FI65, Q6MZQ1, Q6P4I1, Q96AE5, Q96G63, Q9H062, Q9H9B6, Q9NVG7, Q9NZY6
      UniProtKB/TrEMBL
      C9J1X0
      Related
      ENSP00000346466.4, ENST00000354475.5
      Conserved Domains (3) summary
      sd00039
      Location:486 → 557
      7WD40; WD40 repeat [structural motif]
      pfam12881
      Location:253 → 343
      NUT; NUT protein
      cl25539
      Location:407 → 739
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_156130.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009542, AC083862, AK022935
      Related
      ENST00000684339.1

    2. NR_156131.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009542, AC083862, BC017246, DA634150
      Related
      ENST00000684322.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      135183839..135211526 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420266.1 → XP_047276222.1  WD repeat-containing protein 91 isoform X1

      Related
      ENSP00000508083.1, ENST00000683947.1

    2. XM_047420267.1 → XP_047276223.1  WD repeat-containing protein 91 isoform X2

      UniProtKB/TrEMBL
      A0A804HI90
      Related
      ENSP00000506955.1, ENST00000682250.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      136491701..136519383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357997.1 → XP_054213972.1  WD repeat-containing protein 91 isoform X1

    2. XM_054357998.1 → XP_054213973.1  WD repeat-containing protein 91 isoform X2

      UniProtKB/TrEMBL
      A0A804HI90
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4D1P6.2 GenPept UniProtKB/Swiss-Prot:A4D1P6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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