RNF146 ring finger protein 146 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RNF146provided by HGNC
Official Full Name: ring finger protein 146provided by HGNC
Primary source: HGNC:HGNC:21336
See related: Ensembl:ENSG00000118518 MIM:612137; AllianceGenome:HGNC:21336
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Enables poly-ADP-D-ribose binding activity and ubiquitin-protein transferase activity. Involved in positive regulation of canonical Wnt signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol; nucleoplasm; and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in fat (RPKM 18.0), lung (RPKM 11.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q22.33

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (127266682..127288562)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (128455637..128477520)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (127587827..127609707)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SUMOylation of RNF146 results in Axin degradation and activation of Wnt/beta-catenin signaling to promote the progression of hepatocellular carcinoma.
Title: SUMOylation of RNF146 results in Axin degradation and activation of Wnt/β-catenin signaling to promote the progression of hepatocellular carcinoma.
Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.
Title: Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.
Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs.
Title: Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs.
Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation.
Title: Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation.
Rhododendrin is cytoprotective against 6-hydroxydopamine (6-OHDA)-induced cell death, which is largely dependent on ERbeta activity and RNF146 expression.
Title: Rhododendrin-Induced RNF146 Expression via Estrogen Receptor β Activation is Cytoprotective Against 6-OHDA-Induced Oxidative Stress.
RNF146 exerted oncogenic role through ubiquitination of Axin1 to activate beta-catenin signaling.
Title: The E3 ubiquitin ligase RNF146 promotes colorectal cancer by activating the Wnt/β-catenin pathway via ubiquitination of Axin1.
Iduna expression under disruptive neurohomeostasis (e.g., uncompensated oxidative stress or ischemic stroke after MCAo) is upregulated by neuroprotectin D1 and thus serves as a key regulator of cell survival, halting neural cell death.
Title: Neuroprotectin D1 upregulates Iduna expression and provides protection in cellular uncompensated oxidative stress and in experimental ischemic stroke.
the maintenance of unliganded RNF146 in an inactive state may serve to maintain the stability of the RNF146-TNKS complex, which in turn regulates the homeostasis of PARylation-dependent ubiquitination activity in the cell
Title: Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.
RNF146 regulated the development and progression of NSCLC
Title: Overexpression of RNF146 in non-small cell lung cancer enhances proliferation and invasion of tumors through the Wnt/β-catenin signaling pathway.
Iduna is a Poly(ADP-ribose)-dependent ubiquitin E3 ligase.
Title: Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common variants at 6q22 and 17q21 are associated with intracranial volume. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

A003A13 (e-PCR)
- UniSTS:36363

SHGC-36270 (e-PCR)
- UniSTS:56123

RH67929 (e-PCR)
- UniSTS:89282

RH1539 (e-PCR)
- UniSTS:216

Clone Names

dJ351K20.1, 2610509H23Rik, DKFZp434O1427

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables poly-ADP-D-ribose binding	IBA Inferred from Biological aspect of Ancestor more info
enables poly-ADP-D-ribose binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	TAS Traceable Author Statement more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of canonical Wnt signaling pathway	TAS Traceable Author Statement more info
involved_in protein K48-linked ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF146

Names: RING-type E3 ubiquitin transferase RNF146; dactylidin; iduna

NP_001229773.1

EC 2.3.2.27

NP_001229774.1

EC 2.3.2.27

NP_001229775.1

EC 2.3.2.27

NP_001229776.1

EC 2.3.2.27

NP_001229777.1

EC 2.3.2.27

NP_001229778.1

EC 2.3.2.27

NP_001229779.1

EC 2.3.2.27

NP_001229780.1

EC 2.3.2.27

NP_001229781.1

EC 2.3.2.27

NP_112225.2

EC 2.3.2.27

XP_011534463.1

EC 2.3.2.27

XP_011534465.1

EC 2.3.2.27

XP_011534466.1

EC 2.3.2.27

XP_016866825.1

EC 2.3.2.27

XP_047275342.1

EC 2.3.2.27

XP_047275343.1

EC 2.3.2.27

XP_047275344.1

EC 2.3.2.27

XP_047275345.1

EC 2.3.2.27

XP_054212474.1

EC 2.3.2.27

XP_054212475.1

EC 2.3.2.27

XP_054212476.1

EC 2.3.2.27

XP_054212477.1

EC 2.3.2.27

XP_054212478.1

EC 2.3.2.27

XP_054212479.1

EC 2.3.2.27

XP_054212480.1

EC 2.3.2.27

XP_054212481.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001242844.2 → NP_001229773.1 E3 ubiquitin-protein ligase RNF146 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (a). Variants 1-7 encode the same isoform (a).

Source sequence(s)

AJ420549, DA639989

Consensus CDS

CCDS5136.1

UniProtKB/Swiss-Prot

Q9NTX7

Conserved Domains (2) summary

smart00678
Location:103 → 175

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16546
Location:35 → 74

RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
NM_001242845.2 → NP_001229774.1 E3 ubiquitin-protein ligase RNF146 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).

Source sequence(s)

AJ420549, BI669435, DA707096, DB267873

Consensus CDS

CCDS5136.1

UniProtKB/Swiss-Prot

Q9NTX7

Conserved Domains (2) summary

smart00678
Location:103 → 175

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16546
Location:35 → 74

RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
NM_001242846.2 → NP_001229775.1 E3 ubiquitin-protein ligase RNF146 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).

Source sequence(s)

AJ420549, DA043259, DB267873

Consensus CDS

CCDS5136.1

UniProtKB/Swiss-Prot

Q9NTX7

Related

ENSP00000477168.1, ENST00000608991.5

Conserved Domains (2) summary

smart00678
Location:103 → 175

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16546
Location:35 → 74

RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
NM_001242847.2 → NP_001229776.1 E3 ubiquitin-protein ligase RNF146 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).

Source sequence(s)

AJ420549, DA707096

UniProtKB/Swiss-Prot

Q9NTX7

Conserved Domains (2) summary

smart00678
Location:103 → 175

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16546
Location:35 → 74

RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
NM_001242848.2 → NP_001229777.1 E3 ubiquitin-protein ligase RNF146 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).

Source sequence(s)

AJ420549, DA145911

UniProtKB/Swiss-Prot

Q9NTX7

Conserved Domains (2) summary

smart00678
Location:103 → 175

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16546
Location:35 → 74

RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
NM_001242849.2 → NP_001229778.1 E3 ubiquitin-protein ligase RNF146 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (8) lacks two alternate internal exons, which results in the use of an upstream start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus than isoform a. Variants 8-10 encode the same isoform (b).

Source sequence(s)

AI929027, AJ420549, CN388414

Consensus CDS

CCDS56449.1

UniProtKB/Swiss-Prot

E1P572, Q6FIB2, Q7L8H4, Q96K03, Q96T06, Q9NTX6, Q9NTX7

Related

ENSP00000476814.1, ENST00000610153.1

Conserved Domains (2) summary

smart00678
Location:104 → 176

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16546
Location:36 → 75

RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
NM_001242850.2 → NP_001229779.1 E3 ubiquitin-protein ligase RNF146 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (9) lacks two alternate internal exons, which results in the use of an upstream start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus than isoform a. Variants 8-10 encode the same isoform (b).

Source sequence(s)

AJ420549, AK027558

Consensus CDS

CCDS56449.1

UniProtKB/Swiss-Prot

E1P572, Q6FIB2, Q7L8H4, Q96K03, Q96T06, Q9NTX6, Q9NTX7

Related

ENSP00000357297.1, ENST00000368314.6

Conserved Domains (2) summary

smart00678
Location:104 → 176

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16546
Location:36 → 75

RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
NM_001242851.1 → NP_001229780.1 E3 ubiquitin-protein ligase RNF146 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (10) contains an alternate 5' terminal exon and lacks two alternate internal exons, which results in the use of an upstream start codon, compared to variant 1. The encoded isoform (b) has a longer N-terminus than isoform a. Variants 8-10 encode the same isoform (b).

Source sequence(s)

AJ420549, BG708628, BI771613

Consensus CDS

CCDS56449.1

UniProtKB/Swiss-Prot

E1P572, Q6FIB2, Q7L8H4, Q96K03, Q96T06, Q9NTX6, Q9NTX7

Conserved Domains (2) summary

smart00678
Location:104 → 176

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16546
Location:36 → 75

RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
NM_001242852.2 → NP_001229781.1 E3 ubiquitin-protein ligase RNF146 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1-4 and variant 7 encode the same isoform.

Source sequence(s)

AI929027, AJ420549, AL136829, DA826982

Consensus CDS

CCDS5136.1

UniProtKB/Swiss-Prot

Q9NTX7

Conserved Domains (2) summary

smart00678
Location:103 → 175

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16546
Location:35 → 74

RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
NM_030963.4 → NP_112225.2 E3 ubiquitin-protein ligase RNF146 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-7 encode the same isoform (a).

Source sequence(s)

AJ420549, AL136829, DB267873

Consensus CDS

CCDS5136.1

UniProtKB/Swiss-Prot

Q9NTX7

Conserved Domains (2) summary

smart00678
Location:103 → 175

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16546
Location:35 → 74

RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

127266682..127288562

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017011336.3 → XP_016866825.1 E3 ubiquitin-protein ligase RNF146 isoform X1

UniProtKB/Swiss-Prot

E1P572, Q6FIB2, Q7L8H4, Q96K03, Q96T06, Q9NTX6, Q9NTX7

Conserved Domains (2) summary

smart00678
Location:104 → 176

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16546
Location:36 → 75

RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
XM_047419389.1 → XP_047275345.1 E3 ubiquitin-protein ligase RNF146 isoform X2
XM_047419386.1 → XP_047275342.1 E3 ubiquitin-protein ligase RNF146 isoform X2
XM_047419388.1 → XP_047275344.1 E3 ubiquitin-protein ligase RNF146 isoform X2
XM_011536161.4 → XP_011534463.1 E3 ubiquitin-protein ligase RNF146 isoform X2

UniProtKB/Swiss-Prot

Q9NTX7

Conserved Domains (2) summary

smart00678
Location:103 → 175

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16546
Location:35 → 74

RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
XM_011536163.4 → XP_011534465.1 E3 ubiquitin-protein ligase RNF146 isoform X2

UniProtKB/Swiss-Prot

Q9NTX7

Conserved Domains (2) summary

smart00678
Location:103 → 175

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16546
Location:35 → 74

RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
XM_011536164.4 → XP_011534466.1 E3 ubiquitin-protein ligase RNF146 isoform X2

UniProtKB/Swiss-Prot

Q9NTX7

Conserved Domains (2) summary

smart00678
Location:103 → 175

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16546
Location:35 → 74

RING-HC_RNF146; RING finger, HC subclass, found in RING finger protein 146 (RNF146) and similar proteins
XM_047419387.1 → XP_047275343.1 E3 ubiquitin-protein ligase RNF146 isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

128455637..128477520

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054356499.1 → XP_054212474.1 E3 ubiquitin-protein ligase RNF146 isoform X1

UniProtKB/Swiss-Prot

E1P572, Q6FIB2, Q7L8H4, Q96K03, Q96T06, Q9NTX6, Q9NTX7
XM_054356503.1 → XP_054212478.1 E3 ubiquitin-protein ligase RNF146 isoform X2
XM_054356500.1 → XP_054212475.1 E3 ubiquitin-protein ligase RNF146 isoform X2
XM_054356502.1 → XP_054212477.1 E3 ubiquitin-protein ligase RNF146 isoform X2
XM_054356504.1 → XP_054212479.1 E3 ubiquitin-protein ligase RNF146 isoform X2
XM_054356505.1 → XP_054212480.1 E3 ubiquitin-protein ligase RNF146 isoform X2
XM_054356506.1 → XP_054212481.1 E3 ubiquitin-protein ligase RNF146 isoform X2
XM_054356501.1 → XP_054212476.1 E3 ubiquitin-protein ligase RNF146 isoform X2