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    MYPOP Myb related transcription factor, partner of profilin [ Homo sapiens (human) ]

    Gene ID: 339344, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MYPOPprovided by HGNC
    Official Full Name
    Myb related transcription factor, partner of profilinprovided by HGNC
    Primary source
    HGNC:HGNC:20178
    See related
    Ensembl:ENSG00000176182 MIM:617861; AllianceGenome:HGNC:20178
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P42pop
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 2.5), spleen (RPKM 2.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MYPOP in Genome Data Viewer
    Location:
    19q13.32
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (45890023..45902613, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48717466..48730055, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46393281..46405871, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10801 Neighboring gene HNF4 motif-containing MPRA enhancer 173 Neighboring gene forkhead box A3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46385156-46385708 Neighboring gene HNF1 motif-containing MPRA enhancer 100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46386261-46386812 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46386813-46387364 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10802 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14828 Neighboring gene interferon regulatory factor 2 binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14829 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14830 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10805 Neighboring gene nanos C2HC-type zinc finger 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46430224-46430724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14831 Neighboring gene CRISPR/Cas9-targeted silencer 7 Neighboring gene NOVA alternative splicing regulator 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46455793-46456740 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr19:46463595-46464168

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Profilin regulates the activity of p42POP, a novel Myb-related transcription factor. Lederer M, et al. J Cell Sci, 2005 Jan 15. PMID 15615774
    2. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. Oliviero G, et al. Sci Rep, 2015 Dec 21. PMID 26687479, Free PMC Article
    3. Assessment of community efforts to advance network-based prediction of protein-protein interactions. Wang XW, et al. Nat Commun, 2023 Mar 22. PMID 36949045, Free PMC Article
    4. A census of human transcription factors: function, expression and evolution. Vaquerizas JM, et al. Nat Rev Genet, 2009 Apr. PMID 19274049
    5. H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. Nakamura K, et al. Nat Cell Biol, 2019 Mar. PMID 30804502, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myb-related transcription factor, partner of profilin
    Names
    myb-related protein p42POP
    p42 Myb-related transcription factor, partner of profilin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012643.4 → NP_001012661.1  myb-related transcription factor, partner of profilin

      See identical proteins and their annotated locations for NP_001012661.1

      Status: VALIDATED

      Source sequence(s)
      AC008623, BC044311, BU196283
      Consensus CDS
      CCDS33055.1
      UniProtKB/Swiss-Prot
      Q86VE0
      Related
      ENSP00000325402.4, ENST00000322217.6
      Conserved Domains (1) summary
      pfam13873
      Location:16 → 92
      Myb_DNA-bind_5; Myb/SANT-like DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      45890023..45902613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438749.1 → XP_047294705.1  myb-related transcription factor, partner of profilin isoform X1

    2. XM_047438750.1 → XP_047294706.1  myb-related transcription factor, partner of profilin isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      48717466..48730055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320826.1 → XP_054176801.1  myb-related transcription factor, partner of profilin isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86VE0.2 GenPept UniProtKB/Swiss-Prot:Q86VE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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