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    TLE1 TLE family member 1, transcriptional corepressor [ Homo sapiens (human) ]

    Gene ID: 7088, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TLE1provided by HGNC
    Official Full Name
    TLE family member 1, transcriptional corepressorprovided by HGNC
    Primary source
    HGNC:HGNC:11837
    See related
    Ensembl:ENSG00000196781 MIM:600189; AllianceGenome:HGNC:11837
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ESG; ESG1; GRG1; TLE-1
    Summary
    Enables DNA-binding transcription factor binding activity; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of anoikis; negative regulation of signal transduction; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in fat (RPKM 15.1), endometrium (RPKM 10.2) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See TLE1 in Genome Data Viewer
    Location:
    9q21.32
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (81583683..81689547, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (93735751..93841617, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (84198598..84304462, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S20 pseudogene 25 Neighboring gene CST complex subunit TEN1-like Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:84138078-84139277 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:84164162-84164662 Neighboring gene VISTA enhancer hs1118 Neighboring gene uncharacterized LOC105376106 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:84207247-84208446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:84210105-84210800 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr9:84210801-84211494 Neighboring gene NANOG hESC enhancer GRCh37_chr9:84236633-84237248 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr9:84237249-84237864 Neighboring gene NANOG hESC enhancer GRCh37_chr9:84238663-84239186 Neighboring gene VISTA enhancer hs1359 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:84278031-84278532 Neighboring gene Sharpr-MPRA regulatory region 9381 Neighboring gene Sharpr-MPRA regulatory region 7656 Neighboring gene VISTA enhancer hs556 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:84303773-84304487 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19976 Neighboring gene TLE1 divergent transcript Neighboring gene ReSE screen-validated silencer GRCh37_chr9:84349086-84349247 Neighboring gene RNA, U6 small nuclear 1035, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:84375421-84375922 Neighboring gene NANOG hESC enhancer GRCh37_chr9:84398794-84399306 Neighboring gene NANOG hESC enhancer GRCh37_chr9:84434914-84435503 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr9:84458661-84459441 Neighboring gene RNA, 5S ribosomal pseudogene 287

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Transducing-Like Enhancer of Split 1: A Potential Immunohistochemical Marker for Glomus Tumor. Bozdogan N, et al. Am J Dermatopathol, 2017 Jul. PMID 28632567
    2. TLE1 expression fails to distinguish between synovial sarcoma, atypical fibroxanthoma, and dermatofibrosarcoma protuberans. Pukhalskaya T, et al. J Cutan Pathol, 2020 Feb. PMID 31614009
    3. The combined use of H3K27 trimethylation and TLE1 can provide additional diagnostic value for malignant peripheral nerve sheath tumor and synovial sarcoma. Khalil EZI, et al. Ann Diagn Pathol, 2020 Apr. PMID 32007715
    4. Reduced Expression of the Co-regulator TLE1 in Type 2 Diabetes Is Associated with Increased Islet α-Cell Number. Armour SL, et al. Endocrinology, 2020 Apr 1. PMID 32065829
    5. Frequent TLE1 Expression in Cutaneous Neoplasms. Xiong Y, et al. Am J Dermatopathol, 2019 Jan. PMID 30608261

    See all (141) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GRg1 inhibits the TLR4/NF-kB signaling pathway by upregulating miR-216a-5p to reduce growth factors and inflammatory cytokines in DR.
      Title: GRg1 inhibits the TLR4/NF-kB signaling pathway by upregulating miR-216a-5p to reduce growth factors and inflammatory cytokines in DR.
    2. Expression of TLE-1 in Gastrointestinal Stromal Tumour and Its Relationship to Clinicopathological Parameters.
      Title: Expression of TLE-1 in Gastrointestinal Stromal Tumour and Its Relationship to Clinicopathological Parameters.
    3. Prognostic Value of TLE1 Gene Expression in Patients with T-cell Acute Lymphoblastic Leukemia.
      Title: Prognostic Value of TLE1 Gene Expression in Patients with T-cell Acute Lymphoblastic Leukemia.
    4. Tissue microarray based immunohistochemical study of TLE1 in synovial sarcoma and its histologic mimics.
      Title: Tissue microarray based immunohistochemical study of TLE1 in synovial sarcoma and its histologic mimics.
    5. lncRNA RASSF8AS1 suppresses the progression of laryngeal squamous cell carcinoma via targeting the miR664b3p/TLE1 axis.
      Title: lncRNA RASSF8‑AS1 suppresses the progression of laryngeal squamous cell carcinoma via targeting the miR‑664b‑3p/TLE1 axis.
    6. Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.
      Title: Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site.
    7. Gene of the month: TLE 1.
      Title: Gene of the month: TLE 1.
    8. SATB2 and TLE1 Expression in BCOR-CCNB3 (Ewing-like) Sarcoma, Mimicking Small Cell Osteosarcoma and Poorly Differentiated Synovial Sarcoma.
      Title: SATB2 and TLE1 Expression in BCOR-CCNB3 (Ewing-like) Sarcoma, Mimicking Small Cell Osteosarcoma and Poorly Differentiated Synovial Sarcoma.
    9. TLE1 expression fails to distinguish between synovial sarcoma, atypical fibroxanthoma, and dermatofibrosarcoma protuberans.
      Title: TLE1 expression fails to distinguish between synovial sarcoma, atypical fibroxanthoma, and dermatofibrosarcoma protuberans.
    10. The combined use of H3K27 trimethylation and TLE1 can provide additional diagnostic value for malignant peripheral nerve sheath tumor and synovial sarcoma.
      Title: The combined use of H3K27 trimethylation and TLE1 can provide additional diagnostic value for malignant peripheral nerve sheath tumor and synovial sarcoma.
    Submit: New GeneRIF Correction See all GeneRIFs (55)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    EBI GWAS Catalog
    Multiple loci influencing hippocampal degeneration identified by genome scan.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif upregulates the expression of transducin-like enhancer of split 1 homolog protein (TLE1) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of anoikis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical NF-kappaB signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transducin-like enhancer protein 1
    Names
    enhancer of split groucho-like protein 1
    transducin like enhancer of split 1
    transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303103.2 → NP_001290032.1  transducin-like enhancer protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001290032.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB209854, AL353682, AL365190, BC000228, BC010100, DB211613
      UniProtKB/TrEMBL
      B4DEF9
      Conserved Domains (4) summary
      PHA03247
      Location:329 → 486
      PHA03247; large tegument protein UL36; Provisional
      cd00200
      Location:493 → 777
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:497 → 536
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    2. NM_001303104.2 → NP_001290033.1  transducin-like enhancer protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001290033.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate in-frame splice sites compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AB209854, AK293606, AL353682, AL365190, BC010100, DB211613
      UniProtKB/TrEMBL
      B4DEF9
      Conserved Domains (3) summary
      cd00200
      Location:468 → 752
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:472 → 511
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    3. NM_005077.5 → NP_005068.2  transducin-like enhancer protein 1 isoform 2

      See identical proteins and their annotated locations for NP_005068.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB209854, AL365190, BC010100, DB211613
      Consensus CDS
      CCDS6661.1
      UniProtKB/Swiss-Prot
      A8K495, Q04724, Q5T3G4, Q969V9
      UniProtKB/TrEMBL
      B4DEF9
      Related
      ENSP00000365682.3, ENST00000376499.8
      Conserved Domains (4) summary
      PHA03247
      Location:319 → 476
      PHA03247; large tegument protein UL36; Provisional
      cd00200
      Location:483 → 767
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:487 → 526
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      81583683..81689547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006717259.5 → XP_006717322.1  transducin-like enhancer protein 1 isoform X8

      UniProtKB/TrEMBL
      B4DEF9
      Conserved Domains (4) summary
      COG2319
      Location:464 → 756
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:471 → 755
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 77
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:475 → 514
      7WD40; WD40 repeat [structural motif]

    2. XM_047423817.1 → XP_047279773.1  transducin-like enhancer protein 1 isoform X17

      UniProtKB/TrEMBL
      B4DEF9

    3. XM_005252163.3 → XP_005252220.1  transducin-like enhancer protein 1 isoform X16

      See identical proteins and their annotated locations for XP_005252220.1

      UniProtKB/TrEMBL
      B4DEF9
      Conserved Domains (4) summary
      PHA03247
      Location:245 → 402
      PHA03247; large tegument protein UL36; Provisional
      cd00200
      Location:409 → 693
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:413 → 452
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 128
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    4. XM_047423814.1 → XP_047279770.1  transducin-like enhancer protein 1 isoform X12

      UniProtKB/TrEMBL
      B4DEF9

    5. XM_005252162.2 → XP_005252219.1  transducin-like enhancer protein 1 isoform X11

      UniProtKB/TrEMBL
      B4DEF9
      Conserved Domains (4) summary
      COG2319
      Location:436 → 728
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:443 → 727
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 124
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:447 → 486
      7WD40; WD40 repeat [structural motif]

    6. XM_006717263.2 → XP_006717326.1  transducin-like enhancer protein 1 isoform X20

      See identical proteins and their annotated locations for XP_006717326.1

      UniProtKB/TrEMBL
      B4DEF9
      Conserved Domains (3) summary
      cd00200
      Location:481 → 765
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:485 → 524
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 132
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    7. XM_011518951.3 → XP_011517253.1  transducin-like enhancer protein 1 isoform X7

      See identical proteins and their annotated locations for XP_011517253.1

      UniProtKB/TrEMBL
      B4DEF9
      Conserved Domains (4) summary
      PHA03247
      Location:318 → 475
      PHA03247; large tegument protein UL36; Provisional
      cd00200
      Location:482 → 766
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:486 → 525
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 132
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    8. XM_005252154.2 → XP_005252211.1  transducin-like enhancer protein 1 isoform X5

      UniProtKB/TrEMBL
      B4DEF9
      Conserved Domains (4) summary
      COG2319
      Location:509 → 801
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:516 → 800
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 132
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:520 → 559
      7WD40; WD40 repeat [structural motif]

    9. XM_006717262.2 → XP_006717325.1  transducin-like enhancer protein 1 isoform X19

      See identical proteins and their annotated locations for XP_006717325.1

      UniProtKB/TrEMBL
      B4DEF9
      Conserved Domains (3) summary
      cd00200
      Location:482 → 766
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:486 → 525
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:1 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    10. XM_005252153.2 → XP_005252210.1  transducin-like enhancer protein 1 isoform X4

      UniProtKB/TrEMBL
      B4DEF9
      Conserved Domains (4) summary
      COG2319
      Location:510 → 802
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:517 → 801
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:521 → 560
      7WD40; WD40 repeat [structural motif]

    11. XM_047423816.1 → XP_047279772.1  transducin-like enhancer protein 1 isoform X14

      UniProtKB/TrEMBL
      B4DEF9

    12. XM_047423815.1 → XP_047279771.1  transducin-like enhancer protein 1 isoform X13

      UniProtKB/TrEMBL
      B4DEF9
      Conserved Domains (4) summary
      PHA03247
      Location:255 → 412
      PHA03247; large tegument protein UL36; Provisional
      cd00200
      Location:419 → 703
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:423 → 462
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:18 → 124
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    13. XM_047423813.1 → XP_047279769.1  transducin-like enhancer protein 1 isoform X10

      UniProtKB/TrEMBL
      B4DEF9

    14. XM_006717260.2 → XP_006717323.1  transducin-like enhancer protein 1 isoform X9

      UniProtKB/TrEMBL
      B4DEF9
      Conserved Domains (4) summary
      COG2319
      Location:446 → 738
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:453 → 737
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 124
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:457 → 496
      7WD40; WD40 repeat [structural motif]

    15. XM_006717258.2 → XP_006717321.1  transducin-like enhancer protein 1 isoform X3

      UniProtKB/TrEMBL
      B4DEF9
      Conserved Domains (4) summary
      COG2319
      Location:519 → 811
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:526 → 810
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 142
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:530 → 569
      7WD40; WD40 repeat [structural motif]

    16. XM_005252156.4 → XP_005252213.1  transducin-like enhancer protein 1 isoform X6

      See identical proteins and their annotated locations for XP_005252213.1

      UniProtKB/TrEMBL
      B4DEF9
      Conserved Domains (3) summary
      cd00200
      Location:492 → 776
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:496 → 535
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    17. XM_005252152.2 → XP_005252209.1  transducin-like enhancer protein 1 isoform X2

      UniProtKB/TrEMBL
      B4DEF9
      Conserved Domains (4) summary
      COG2319
      Location:519 → 811
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:526 → 810
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:530 → 569
      7WD40; WD40 repeat [structural motif]

    18. XM_005252151.2 → XP_005252208.1  transducin-like enhancer protein 1 isoform X1

      UniProtKB/TrEMBL
      B4DEF9
      Conserved Domains (4) summary
      COG2319
      Location:520 → 812
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:527 → 811
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam03920
      Location:1 → 143
      TLE_N; Groucho/TLE N-terminal Q-rich domain
      sd00039
      Location:531 → 570
      7WD40; WD40 repeat [structural motif]

    19. XM_006717261.3 → XP_006717324.1  transducin-like enhancer protein 1 isoform X15

      UniProtKB/TrEMBL
      B4DEF9
      Conserved Domains (3) summary
      COG2319
      Location:411 → 697
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:416 → 455
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:412 → 696
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    20. XM_047423818.1 → XP_047279774.1  transducin-like enhancer protein 1 isoform X18

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      93735751..93841617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054363664.1 → XP_054219639.1  transducin-like enhancer protein 1 isoform X8

      UniProtKB/TrEMBL
      B4DEF9

    2. XM_054363673.1 → XP_054219648.1  transducin-like enhancer protein 1 isoform X17

      UniProtKB/TrEMBL
      B4DEF9

    3. XM_054363672.1 → XP_054219647.1  transducin-like enhancer protein 1 isoform X16

      UniProtKB/TrEMBL
      B4DEF9

    4. XM_054363668.1 → XP_054219643.1  transducin-like enhancer protein 1 isoform X12

      UniProtKB/TrEMBL
      B4DEF9

    5. XM_054363667.1 → XP_054219642.1  transducin-like enhancer protein 1 isoform X11

      UniProtKB/TrEMBL
      B4DEF9

    6. XM_054363676.1 → XP_054219651.1  transducin-like enhancer protein 1 isoform X20

      UniProtKB/TrEMBL
      B4DEF9

    7. XM_054363663.1 → XP_054219638.1  transducin-like enhancer protein 1 isoform X7

      UniProtKB/TrEMBL
      B4DEF9

    8. XM_054363661.1 → XP_054219636.1  transducin-like enhancer protein 1 isoform X5

      UniProtKB/TrEMBL
      B4DEF9

    9. XM_054363675.1 → XP_054219650.1  transducin-like enhancer protein 1 isoform X19

      UniProtKB/TrEMBL
      B4DEF9

    10. XM_054363660.1 → XP_054219635.1  transducin-like enhancer protein 1 isoform X4

      UniProtKB/TrEMBL
      B4DEF9

    11. XM_054363670.1 → XP_054219645.1  transducin-like enhancer protein 1 isoform X14

      UniProtKB/TrEMBL
      B4DEF9

    12. XM_054363669.1 → XP_054219644.1  transducin-like enhancer protein 1 isoform X13

      UniProtKB/TrEMBL
      B4DEF9

    13. XM_054363666.1 → XP_054219641.1  transducin-like enhancer protein 1 isoform X10

      UniProtKB/TrEMBL
      B4DEF9

    14. XM_054363665.1 → XP_054219640.1  transducin-like enhancer protein 1 isoform X9

      UniProtKB/TrEMBL
      B4DEF9

    15. XM_054363659.1 → XP_054219634.1  transducin-like enhancer protein 1 isoform X3

      UniProtKB/TrEMBL
      B4DEF9

    16. XM_054363662.1 → XP_054219637.1  transducin-like enhancer protein 1 isoform X6

      UniProtKB/TrEMBL
      B4DEF9

    17. XM_054363658.1 → XP_054219633.1  transducin-like enhancer protein 1 isoform X2

      UniProtKB/TrEMBL
      B4DEF9

    18. XM_054363657.1 → XP_054219632.1  transducin-like enhancer protein 1 isoform X1

      UniProtKB/TrEMBL
      B4DEF9

    19. XM_054363671.1 → XP_054219646.1  transducin-like enhancer protein 1 isoform X15

      UniProtKB/TrEMBL
      B4DEF9

    20. XM_054363674.1 → XP_054219649.1  transducin-like enhancer protein 1 isoform X18

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04724.2 GenPept UniProtKB/Swiss-Prot:Q04724

    Gene LinkOut

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